Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals
ABSTRACT: The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a s...
- Autores:
-
Ruiz Linares, Andrés
Adhikari, Kaustubh
Acuña Alonzo, Víctor
Quinto Sánchez, Mirsha
Jaramillo, Claudia
Arias Pérez, William Hernán
Fuentes, Macarena
Pizarro, María
Everardo, Paola
De Avila, Francisco
Gómez Valdés, Jorge
León Mimila, Paola
Hunemeier, Tábita
Ramallo, Virginia
Silva de Cerqueira, Caio C.
Burley, Mari Wyn
Konca, Esra
Zagonel de Oliveira, Marcelo
Veronez, Mauricio Roberto
Rubio Codina, Marta
Attanasio, Orazio
Gibbon, Sahra
Ray, Nicolas
Gallo, Carla
Poletti, Giovanni
Rosique Gracia, Javier
Schuler Faccini, Lavinia
Salzano, Francisco M.
Bortolini, Maria Cátira
Cañizales Quintero, Samuel
Rothhammer, Francisco
Bedoya Berrío, Gabriel de Jesús
Balding, David
Gonzalez José, Rolando
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/8625
- Palabra clave:
- América Latina
América Latina - Geografía
Diversidad
Diversidad genética humana
Fenotipo
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 2.5 Colombia
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| dc.title.spa.fl_str_mv |
Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals |
| title |
Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals |
| spellingShingle |
Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals América Latina América Latina - Geografía Diversidad Diversidad genética humana Fenotipo |
| title_short |
Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals |
| title_full |
Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals |
| title_fullStr |
Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals |
| title_full_unstemmed |
Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals |
| title_sort |
Admixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals |
| dc.creator.fl_str_mv |
Ruiz Linares, Andrés Adhikari, Kaustubh Acuña Alonzo, Víctor Quinto Sánchez, Mirsha Jaramillo, Claudia Arias Pérez, William Hernán Fuentes, Macarena Pizarro, María Everardo, Paola De Avila, Francisco Gómez Valdés, Jorge León Mimila, Paola Hunemeier, Tábita Ramallo, Virginia Silva de Cerqueira, Caio C. Burley, Mari Wyn Konca, Esra Zagonel de Oliveira, Marcelo Veronez, Mauricio Roberto Rubio Codina, Marta Attanasio, Orazio Gibbon, Sahra Ray, Nicolas Gallo, Carla Poletti, Giovanni Rosique Gracia, Javier Schuler Faccini, Lavinia Salzano, Francisco M. Bortolini, Maria Cátira Cañizales Quintero, Samuel Rothhammer, Francisco Bedoya Berrío, Gabriel de Jesús Balding, David Gonzalez José, Rolando |
| dc.contributor.author.none.fl_str_mv |
Ruiz Linares, Andrés Adhikari, Kaustubh Acuña Alonzo, Víctor Quinto Sánchez, Mirsha Jaramillo, Claudia Arias Pérez, William Hernán Fuentes, Macarena Pizarro, María Everardo, Paola De Avila, Francisco Gómez Valdés, Jorge León Mimila, Paola Hunemeier, Tábita Ramallo, Virginia Silva de Cerqueira, Caio C. Burley, Mari Wyn Konca, Esra Zagonel de Oliveira, Marcelo Veronez, Mauricio Roberto Rubio Codina, Marta Attanasio, Orazio Gibbon, Sahra Ray, Nicolas Gallo, Carla Poletti, Giovanni Rosique Gracia, Javier Schuler Faccini, Lavinia Salzano, Francisco M. Bortolini, Maria Cátira Cañizales Quintero, Samuel Rothhammer, Francisco Bedoya Berrío, Gabriel de Jesús Balding, David Gonzalez José, Rolando |
| dc.subject.none.fl_str_mv |
América Latina América Latina - Geografía Diversidad Diversidad genética humana Fenotipo |
| topic |
América Latina América Latina - Geografía Diversidad Diversidad genética humana Fenotipo |
| description |
ABSTRACT: The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a sample of 7,342 subjects ascertained in five countries (Brazil, Chile, Colombia, Me´xico and Peru´ ). These individuals were also characterized for a range of physical appearance traits and for selfperception of ancestry. The geographic distribution of admixture proportions in this sample reveals extensive population structure, illustrating the continuing impact of demographic history on the genetic diversity of Latin America. Significant ancestry effects were detected for most phenotypes studied. However, ancestry generally explains only a modest proportion of total phenotypic variation. Genetically estimated and self-perceived ancestry correlate significantly, but certain physical attributes have a strong impact on self-perception and bias self-perception of ancestry relative to genetically estimated ancestry. |
| publishDate |
2014 |
| dc.date.issued.none.fl_str_mv |
2014 |
| dc.date.accessioned.none.fl_str_mv |
2017-10-23T21:27:46Z |
| dc.date.available.none.fl_str_mv |
2017-10-23T21:27:46Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Ruiz Linares, A., Adhikari, K., Acuña Alonzo, V., Quinto Sánchez, M., Jaramillo, C., Arias, W., … Gonzalez José, R. (2014). Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7.342 individuals. PLoS Genet, 10(9), 1–13. DOI: http://doi.org/https://doi.org/10.1371/journal.pgen.1004572 |
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1553-7404 |
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http://hdl.handle.net/10495/8625 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1371/journal.pgen.1004572 |
| dc.identifier.eissn.none.fl_str_mv |
1553-7390 |
| dc.identifier.url.none.fl_str_mv |
sixl126Bt6U |
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Ruiz Linares, A., Adhikari, K., Acuña Alonzo, V., Quinto Sánchez, M., Jaramillo, C., Arias, W., … Gonzalez José, R. (2014). Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7.342 individuals. PLoS Genet, 10(9), 1–13. DOI: http://doi.org/https://doi.org/10.1371/journal.pgen.1004572 1553-7404 1553-7390 sixl126Bt6U |
| url |
http://hdl.handle.net/10495/8625 https://doi.org/10.1371/journal.pgen.1004572 |
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eng |
| language |
eng |
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PLoS Genet. |
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Atribución-NoComercial-SinDerivadas 2.5 Colombia |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Atribución-NoComercial-SinDerivadas 2.5 Colombia http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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Gene Tolls |
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Grupo de Investigación Medio Ambiente y Sociedad (MASO) |
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Estados Unidos |
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Universidad de Antioquia |
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Ruiz Linares, AndrésAdhikari, KaustubhAcuña Alonzo, VíctorQuinto Sánchez, MirshaJaramillo, ClaudiaArias Pérez, William HernánFuentes, MacarenaPizarro, MaríaEverardo, PaolaDe Avila, FranciscoGómez Valdés, JorgeLeón Mimila, PaolaHunemeier, TábitaRamallo, VirginiaSilva de Cerqueira, Caio C.Burley, Mari WynKonca, EsraZagonel de Oliveira, MarceloVeronez, Mauricio RobertoRubio Codina, MartaAttanasio, OrazioGibbon, SahraRay, NicolasGallo, CarlaPoletti, GiovanniRosique Gracia, JavierSchuler Faccini, LaviniaSalzano, Francisco M.Bortolini, Maria CátiraCañizales Quintero, SamuelRothhammer, FranciscoBedoya Berrío, Gabriel de JesúsBalding, DavidGonzalez José, Rolando2017-10-23T21:27:46Z2017-10-23T21:27:46Z2014Ruiz Linares, A., Adhikari, K., Acuña Alonzo, V., Quinto Sánchez, M., Jaramillo, C., Arias, W., … Gonzalez José, R. (2014). Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7.342 individuals. PLoS Genet, 10(9), 1–13. DOI: http://doi.org/https://doi.org/10.1371/journal.pgen.10045721553-7404http://hdl.handle.net/10495/8625https://doi.org/10.1371/journal.pgen.10045721553-7390sixl126Bt6UABSTRACT: The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a sample of 7,342 subjects ascertained in five countries (Brazil, Chile, Colombia, Me´xico and Peru´ ). These individuals were also characterized for a range of physical appearance traits and for selfperception of ancestry. The geographic distribution of admixture proportions in this sample reveals extensive population structure, illustrating the continuing impact of demographic history on the genetic diversity of Latin America. Significant ancestry effects were detected for most phenotypes studied. However, ancestry generally explains only a modest proportion of total phenotypic variation. Genetically estimated and self-perceived ancestry correlate significantly, but certain physical attributes have a strong impact on self-perception and bias self-perception of ancestry relative to genetically estimated ancestry.application/pdfGene TollsGrupo de Investigación Medio Ambiente y Sociedad (MASO)Estados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-SinDerivadas 2.5 Colombiainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/América LatinaAmérica Latina - GeografíaDiversidadDiversidad genética humanaFenotipoAdmixture in Latin America : geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individualsPLoS Genet.engPLoS Genet113109ORIGINALRuizAndres_2014_AdmixtureLatinAmerica.pdfRuizAndres_2014_AdmixtureLatinAmerica.pdfArtículo de Revistaapplication/pdf1853859http://bibliotecadigital.udea.edu.co/bitstream/10495/8625/1/RuizAndres_2014_AdmixtureLatinAmerica.pdf7a275ed0d187e3c2a4ac8c8d90ca72b4MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/8625/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/8625/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfLicenciaapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/8625/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/8625/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/8625oai:bibliotecadigital.udea.edu.co:10495/86252021-05-20 10:11:20.178Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |