Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi

ABSTRACT: Dimorphic fungal pathogens cause a significant human disease burden and unlike most fungal pathogens affect immunocompetent hosts. To examine the origin of virulence of these fungal pathogens, we compared genomes of classic systemic, opportunistic, and non-pathogenic species, including Emm...

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Autores:
Muñoz Gómez, José Fernando
McEwen Ochoa, Juan Guillermo
Clay, Oliver K.
Cuomo, Christina
Tipo de recurso:
Article of investigation
Fecha de publicación:
2018
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/23011
Acceso en línea:
http://hdl.handle.net/10495/23011
Palabra clave:
Hongos
Fungi
Chrysosporium
Micosis
Mycoses
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
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oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/23011
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repository_id_str
dc.title.spa.fl_str_mv Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
spellingShingle Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
Hongos
Fungi
Chrysosporium
Micosis
Mycoses
title_short Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title_full Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title_fullStr Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title_full_unstemmed Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title_sort Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
dc.creator.fl_str_mv Muñoz Gómez, José Fernando
McEwen Ochoa, Juan Guillermo
Clay, Oliver K.
Cuomo, Christina
dc.contributor.author.none.fl_str_mv Muñoz Gómez, José Fernando
McEwen Ochoa, Juan Guillermo
Clay, Oliver K.
Cuomo, Christina
dc.subject.decs.none.fl_str_mv Hongos
Fungi
Chrysosporium
Micosis
Mycoses
topic Hongos
Fungi
Chrysosporium
Micosis
Mycoses
description ABSTRACT: Dimorphic fungal pathogens cause a significant human disease burden and unlike most fungal pathogens affect immunocompetent hosts. To examine the origin of virulence of these fungal pathogens, we compared genomes of classic systemic, opportunistic, and non-pathogenic species, including Emmonsia and two basal branching, non-pathogenic species in the Ajellomycetaceae, Helicocarpus griseus and Polytolypa hystricis. We found that gene families related to plant degradation, secondary metabolites synthesis, and amino acid and lipid metabolism are retained in H. griseus and P. hystricis. While genes involved in the virulence of dimorphic pathogenic fungi are conserved in saprophytes, changes in the copy number of proteases, kinases and transcription factors in systemic dimorphic relative to non-dimorphic species may have aided the evolution of specialized gene regulatory programs to rapidly adapt to higher temperatures and new nutritional environments. Notably, both of the basal branching, non-pathogenic species appear homothallic, with both mating type locus idiomorphs fused at a single locus, whereas all related pathogenic species are heterothallic. These differences revealed that independent changes in nutrient acquisition capacity have occurred in the Onygenaceae and Ajellomycetaceae, and underlie how the dimorphic pathogens have adapted to the human host and decreased their capacity for growth in environmental niches.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2021-10-08T01:44:47Z
dc.date.available.none.fl_str_mv 2021-10-08T01:44:47Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.spa.fl_str_mv Muñoz, JF, McEwen, JG, Clay, OK et al. El análisis del genoma revela mecanismos evolutivos de adaptación en hongos dimórficos sistémicos. Sci Rep 8, 4473 (2018). https://doi.org/10.1038/s41598-018-22816-6
dc.identifier.issn.none.fl_str_mv 2045-2322
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/23011
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-018-22816-6
identifier_str_mv Muñoz, JF, McEwen, JG, Clay, OK et al. El análisis del genoma revela mecanismos evolutivos de adaptación en hongos dimórficos sistémicos. Sci Rep 8, 4473 (2018). https://doi.org/10.1038/s41598-018-22816-6
2045-2322
10.1038/s41598-018-22816-6
url http://hdl.handle.net/10495/23011
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Sci. Rep.
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dc.format.extent.spa.fl_str_mv 13
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dc.publisher.spa.fl_str_mv Nature Publishing Group
dc.publisher.group.spa.fl_str_mv Biología Celular y Molecular CIB U. de A. U. del Rosario
dc.publisher.place.spa.fl_str_mv Londres, Inglaterra
institution Universidad de Antioquia
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spelling Muñoz Gómez, José FernandoMcEwen Ochoa, Juan GuillermoClay, Oliver K.Cuomo, Christina2021-10-08T01:44:47Z2021-10-08T01:44:47Z2018Muñoz, JF, McEwen, JG, Clay, OK et al. El análisis del genoma revela mecanismos evolutivos de adaptación en hongos dimórficos sistémicos. Sci Rep 8, 4473 (2018). https://doi.org/10.1038/s41598-018-22816-62045-2322http://hdl.handle.net/10495/2301110.1038/s41598-018-22816-6ABSTRACT: Dimorphic fungal pathogens cause a significant human disease burden and unlike most fungal pathogens affect immunocompetent hosts. To examine the origin of virulence of these fungal pathogens, we compared genomes of classic systemic, opportunistic, and non-pathogenic species, including Emmonsia and two basal branching, non-pathogenic species in the Ajellomycetaceae, Helicocarpus griseus and Polytolypa hystricis. We found that gene families related to plant degradation, secondary metabolites synthesis, and amino acid and lipid metabolism are retained in H. griseus and P. hystricis. While genes involved in the virulence of dimorphic pathogenic fungi are conserved in saprophytes, changes in the copy number of proteases, kinases and transcription factors in systemic dimorphic relative to non-dimorphic species may have aided the evolution of specialized gene regulatory programs to rapidly adapt to higher temperatures and new nutritional environments. Notably, both of the basal branching, non-pathogenic species appear homothallic, with both mating type locus idiomorphs fused at a single locus, whereas all related pathogenic species are heterothallic. These differences revealed that independent changes in nutrient acquisition capacity have occurred in the Onygenaceae and Ajellomycetaceae, and underlie how the dimorphic pathogens have adapted to the human host and decreased their capacity for growth in environmental niches.COL000096213application/pdfengNature Publishing GroupBiología Celular y Molecular CIB U. de A. U. del RosarioLondres, Inglaterrainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungiHongosFungiChrysosporiumMicosisMycosesSci. Rep.Scientific Reports1138ORIGINALMuñozJose_2018_GenomeAnalysisReveals.pdfMuñozJose_2018_GenomeAnalysisReveals.pdfArtículo de investigaciónapplication/pdf4228784http://bibliotecadigital.udea.edu.co/bitstream/10495/23011/1/Mu%c3%b1ozJose_2018_GenomeAnalysisReveals.pdf58d03f47c84d6d4d89ab368a49b45e37MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927http://bibliotecadigital.udea.edu.co/bitstream/10495/23011/2/license_rdf1646d1f6b96dbbbc38035efc9239ac9cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/23011/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/23011oai:bibliotecadigital.udea.edu.co:10495/230112021-10-07 20:44:47.864Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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