In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid

ABSTRACT : Introduction: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We c...

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Autores:
Vanegas Múnera, Johanna Marcela
Ocampo Ríos, Ana María
Montoya Urrego, Daniela
Jiménez Quiceno, Judy Natalia
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/26501
Acceso en línea:
http://hdl.handle.net/10495/26501
Palabra clave:
Antibacterianos
Anti-Bacterial Agents
Staphylococcus aureus Resistente a Meticilina
Methicillin-Resistant Staphylococcus aureus
Linezolid
Vancomicina
Vancomycin
Daptomicina
Daptomycin
Pruebas de Sensibilidad Microbiana
Microbial Sensitivity Tests
Infecciones de los Tejidos Blandos
Soft Tissue Infections
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_c84492cdb3e87575d80050d0ee2fb3dd
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/26501
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid
title In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid
spellingShingle In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid
Antibacterianos
Anti-Bacterial Agents
Staphylococcus aureus Resistente a Meticilina
Methicillin-Resistant Staphylococcus aureus
Linezolid
Vancomicina
Vancomycin
Daptomicina
Daptomycin
Pruebas de Sensibilidad Microbiana
Microbial Sensitivity Tests
Infecciones de los Tejidos Blandos
Soft Tissue Infections
title_short In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid
title_full In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid
title_fullStr In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid
title_full_unstemmed In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid
title_sort In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolid
dc.creator.fl_str_mv Vanegas Múnera, Johanna Marcela
Ocampo Ríos, Ana María
Montoya Urrego, Daniela
Jiménez Quiceno, Judy Natalia
dc.contributor.author.none.fl_str_mv Vanegas Múnera, Johanna Marcela
Ocampo Ríos, Ana María
Montoya Urrego, Daniela
Jiménez Quiceno, Judy Natalia
dc.subject.decs.none.fl_str_mv Antibacterianos
Anti-Bacterial Agents
Staphylococcus aureus Resistente a Meticilina
Methicillin-Resistant Staphylococcus aureus
Linezolid
Vancomicina
Vancomycin
Daptomicina
Daptomycin
Pruebas de Sensibilidad Microbiana
Microbial Sensitivity Tests
Infecciones de los Tejidos Blandos
Soft Tissue Infections
topic Antibacterianos
Anti-Bacterial Agents
Staphylococcus aureus Resistente a Meticilina
Methicillin-Resistant Staphylococcus aureus
Linezolid
Vancomicina
Vancomycin
Daptomicina
Daptomycin
Pruebas de Sensibilidad Microbiana
Microbial Sensitivity Tests
Infecciones de los Tejidos Blandos
Soft Tissue Infections
description ABSTRACT : Introduction: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We conducted a study to determine in vitro susceptibility to vancomycin, daptomycin, linezolid and tedizolid in MRSA clinical isolates from adult patients with skin and soft tissue infections. Material and methods: Methicillin-resistant S. aureus isolates were collected in three tertiarycare hospitals of Medellin, Colombia, from February 2008 to June 2010 as part of a previous study. Clinical characteristics were assessed by medical records and MIC values were determined by Epsilometer test. Genotypic analysis included spa typing, MLST, and SCCmec typing. Results: A total of 150 MRSA isolates were evaluated and tedizolid MIC values obtained showed higher in vitro activity than other antimicrobials, with MIC values ranging from 0.13g/mL to 0.75g/mL and lower values of MIC50 and MIC90 (0.38g/mL and 0.5g/mL). In contrast, vancomycin and linezolid had higher MIC values, which ranged from 0.5g/mL to 2.0g/mL and from 0.38g/mL to 4.0g/mL, respectively. Tedizolid MICs were 2- to 5-fold lower than those of linezolid. Clinical characteristics showed high previous antimicrobial use and hospitalization history. The majority of the strains belong to the CC8 harboring the SCCmec IVc and were associated with the spa t1610 (29.33%, n = 44). Conclusion: In vitro effectiveness of tedizolid was superior for isolates from skin and soft tissue infections in comparison with the other antibiotics evaluated. The above added to its less toxicity, good bioavailability, daily dose and unnecessity of dosage adjustment, make tedizolid in a promising alternative for the treatment of infections caused by MRSA.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2022-03-10T17:21:47Z
dc.date.available.none.fl_str_mv 2022-03-10T17:21:47Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.local.spa.fl_str_mv Artículo de investigación
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dc.identifier.citation.spa.fl_str_mv Vanegas Múnera JM, Ocampo Ríos AM, Urrego DM, Jiménez Quiceno JN. In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid. Braz J Infect Dis. 2017 Sep-Oct;21(5):493-499. doi: 10.1016/j.bjid.2017.03.010.
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/26501
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjid.2017.03.010
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv Vanegas Múnera JM, Ocampo Ríos AM, Urrego DM, Jiménez Quiceno JN. In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid. Braz J Infect Dis. 2017 Sep-Oct;21(5):493-499. doi: 10.1016/j.bjid.2017.03.010.
1413-8670
10.1016/j.bjid.2017.03.010
1678-4391
url http://hdl.handle.net/10495/26501
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Braz. J. Infect. Dis.
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.format.extent.spa.fl_str_mv 7
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.group.spa.fl_str_mv Grupo de Investigación en Microbiología Básica y Aplicada-Microba
dc.publisher.place.spa.fl_str_mv Río de Janeiro, Brasil
institution Universidad de Antioquia
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spelling Vanegas Múnera, Johanna MarcelaOcampo Ríos, Ana MaríaMontoya Urrego, DanielaJiménez Quiceno, Judy Natalia2022-03-10T17:21:47Z2022-03-10T17:21:47Z2017Vanegas Múnera JM, Ocampo Ríos AM, Urrego DM, Jiménez Quiceno JN. In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid. Braz J Infect Dis. 2017 Sep-Oct;21(5):493-499. doi: 10.1016/j.bjid.2017.03.010.1413-8670http://hdl.handle.net/10495/2650110.1016/j.bjid.2017.03.0101678-4391ABSTRACT : Introduction: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We conducted a study to determine in vitro susceptibility to vancomycin, daptomycin, linezolid and tedizolid in MRSA clinical isolates from adult patients with skin and soft tissue infections. Material and methods: Methicillin-resistant S. aureus isolates were collected in three tertiarycare hospitals of Medellin, Colombia, from February 2008 to June 2010 as part of a previous study. Clinical characteristics were assessed by medical records and MIC values were determined by Epsilometer test. Genotypic analysis included spa typing, MLST, and SCCmec typing. Results: A total of 150 MRSA isolates were evaluated and tedizolid MIC values obtained showed higher in vitro activity than other antimicrobials, with MIC values ranging from 0.13g/mL to 0.75g/mL and lower values of MIC50 and MIC90 (0.38g/mL and 0.5g/mL). In contrast, vancomycin and linezolid had higher MIC values, which ranged from 0.5g/mL to 2.0g/mL and from 0.38g/mL to 4.0g/mL, respectively. Tedizolid MICs were 2- to 5-fold lower than those of linezolid. Clinical characteristics showed high previous antimicrobial use and hospitalization history. The majority of the strains belong to the CC8 harboring the SCCmec IVc and were associated with the spa t1610 (29.33%, n = 44). Conclusion: In vitro effectiveness of tedizolid was superior for isolates from skin and soft tissue infections in comparison with the other antibiotics evaluated. The above added to its less toxicity, good bioavailability, daily dose and unnecessity of dosage adjustment, make tedizolid in a promising alternative for the treatment of infections caused by MRSA.COL01261317application/pdfengElsevierGrupo de Investigación en Microbiología Básica y Aplicada-MicrobaRío de Janeiro, Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid, and tedizolidAntibacterianosAnti-Bacterial AgentsStaphylococcus aureus Resistente a MeticilinaMethicillin-Resistant Staphylococcus aureusLinezolidVancomicinaVancomycinDaptomicinaDaptomycinPruebas de Sensibilidad MicrobianaMicrobial Sensitivity TestsInfecciones de los Tejidos BlandosSoft Tissue InfectionsBraz. J. Infect. Dis.Brazilian Journal of Infectious Diseases493499215ORIGINALMontoyaDaniela_2017_StaphylococcusAureusIsolates.pdfMontoyaDaniela_2017_StaphylococcusAureusIsolates.pdfArtículo de investigaciónapplication/pdf860766http://bibliotecadigital.udea.edu.co/bitstream/10495/26501/1/MontoyaDaniela_2017_StaphylococcusAureusIsolates.pdfbaf034ea2aaa62be96440e6d713d2aa4MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823http://bibliotecadigital.udea.edu.co/bitstream/10495/26501/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/26501/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/26501oai:bibliotecadigital.udea.edu.co:10495/265012022-04-22 10:23:42.596Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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