Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients
ABSTRACT: Hyper-IgE syndrome (HIES) is a rare multisystem disorder characterized by increased susceptibility to infections associated with heterogeneous immunologic and non-immunologic abnormalities. Most patients consistently exhibit defective antigen-induced-T cell activation, that could be partly...
- Autores:
-
Franco Restrepo, José Luis
Montoya Guarín, Carlos Julio
Rúgeles López, María Teresa
Patiño Grisales, Pablo Javier
Martínez Villarreal, Adriano Miguel
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2004
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/35161
- Acceso en línea:
- https://hdl.handle.net/10495/35161
- Palabra clave:
- Job Syndrome
Síndrome de Job
Infections
Infecciones
Leukocytes, Mononuclear
Leucocitos Mononucleares
Intercellular Adhesion Molecule-1
Molécula 1 de Adhesión Intercelular
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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| dc.title.spa.fl_str_mv |
Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients |
| title |
Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients |
| spellingShingle |
Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients Job Syndrome Síndrome de Job Infections Infecciones Leukocytes, Mononuclear Leucocitos Mononucleares Intercellular Adhesion Molecule-1 Molécula 1 de Adhesión Intercelular |
| title_short |
Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients |
| title_full |
Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients |
| title_fullStr |
Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients |
| title_full_unstemmed |
Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients |
| title_sort |
Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome Patients |
| dc.creator.fl_str_mv |
Franco Restrepo, José Luis Montoya Guarín, Carlos Julio Rúgeles López, María Teresa Patiño Grisales, Pablo Javier Martínez Villarreal, Adriano Miguel |
| dc.contributor.author.none.fl_str_mv |
Franco Restrepo, José Luis Montoya Guarín, Carlos Julio Rúgeles López, María Teresa Patiño Grisales, Pablo Javier Martínez Villarreal, Adriano Miguel |
| dc.contributor.researchgroup.spa.fl_str_mv |
Inmunodeficiencias Primarias |
| dc.subject.decs.none.fl_str_mv |
Job Syndrome Síndrome de Job Infections Infecciones Leukocytes, Mononuclear Leucocitos Mononucleares Intercellular Adhesion Molecule-1 Molécula 1 de Adhesión Intercelular |
| topic |
Job Syndrome Síndrome de Job Infections Infecciones Leukocytes, Mononuclear Leucocitos Mononucleares Intercellular Adhesion Molecule-1 Molécula 1 de Adhesión Intercelular |
| description |
ABSTRACT: Hyper-IgE syndrome (HIES) is a rare multisystem disorder characterized by increased susceptibility to infections associated with heterogeneous immunologic and non-immunologic abnormalities. Most patients consistently exhibit defective antigen-induced-T cell activation, that could be partly due to altered costimulation involving accessory molecules; however, the expression of these molecules has never been documented in HIES. Therefore, we investigated the expression of CD11a, CD28, CD40, CD54, CD80, CD86, and CD154 in peripheral blood mononuclear cells from six patients and six healthy controls by flow cytometry after autologous and mixed allogeneic reactions. Only the allogeneic stimuli induced significant proliferative responses and interleukin 2 and interferon gamma production in both groups. Most accessory molecules showed similar expression between patients and controls with the exception of CD54, being expressed at lower levels in HIES patients regardless of the type of stimulus used. Decreased expression of CD54 could partly explain the deficient T cell activation to specific recall antigens in HIES patients, and might be responsible for their higher susceptibility to infections with defined types of microorganisms. |
| publishDate |
2004 |
| dc.date.issued.none.fl_str_mv |
2004 |
| dc.date.accessioned.none.fl_str_mv |
2023-05-30T20:32:52Z |
| dc.date.available.none.fl_str_mv |
2023-05-30T20:32:52Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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0074-0276 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/35161 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/s0074-02762004000200008 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
0074-0276 10.1590/s0074-02762004000200008 1678-8060 |
| url |
https://hdl.handle.net/10495/35161 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Mem. Inst. Oswaldo Cruz. |
| dc.relation.citationendpage.spa.fl_str_mv |
165 |
| dc.relation.citationissue.spa.fl_str_mv |
2 |
| dc.relation.citationstartpage.spa.fl_str_mv |
159 |
| dc.relation.citationvolume.spa.fl_str_mv |
99 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Memórias do Instituto Oswaldo Cruz |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/2.5/co/ https://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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| dc.publisher.spa.fl_str_mv |
Instituto Oswaldo Cruz |
| dc.publisher.place.spa.fl_str_mv |
Río de Janeiro, Brasil |
| dc.publisher.faculty.spa.fl_str_mv |
sin facultad - programa |
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Universidad de Antioquia |
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Franco Restrepo, José LuisMontoya Guarín, Carlos JulioRúgeles López, María TeresaPatiño Grisales, Pablo JavierMartínez Villarreal, Adriano MiguelInmunodeficiencias Primarias2023-05-30T20:32:52Z2023-05-30T20:32:52Z20040074-0276https://hdl.handle.net/10495/3516110.1590/s0074-027620040002000081678-8060ABSTRACT: Hyper-IgE syndrome (HIES) is a rare multisystem disorder characterized by increased susceptibility to infections associated with heterogeneous immunologic and non-immunologic abnormalities. Most patients consistently exhibit defective antigen-induced-T cell activation, that could be partly due to altered costimulation involving accessory molecules; however, the expression of these molecules has never been documented in HIES. Therefore, we investigated the expression of CD11a, CD28, CD40, CD54, CD80, CD86, and CD154 in peripheral blood mononuclear cells from six patients and six healthy controls by flow cytometry after autologous and mixed allogeneic reactions. Only the allogeneic stimuli induced significant proliferative responses and interleukin 2 and interferon gamma production in both groups. Most accessory molecules showed similar expression between patients and controls with the exception of CD54, being expressed at lower levels in HIES patients regardless of the type of stimulus used. Decreased expression of CD54 could partly explain the deficient T cell activation to specific recall antigens in HIES patients, and might be responsible for their higher susceptibility to infections with defined types of microorganisms.Universidad de Antioquia. Vicerrectoría de investigación. Comité para el Desarrollo de la Investigación - CODICOL00124267application/pdfengInstituto Oswaldo CruzRío de Janeiro, Brasilsin facultad - programahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Abnormal Expression of CD54 in Mixed Reactions of Mononuclear Cells from Hyper-IgE Syndrome PatientsArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionJob SyndromeSíndrome de JobInfectionsInfeccionesLeukocytes, MononuclearLeucocitos MononuclearesIntercellular Adhesion Molecule-1Molécula 1 de Adhesión IntercelularMem. Inst. 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