Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)

ABSTRACT: Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extr...

Full description

Autores:
Pabón Vidal, Adriana Lucía
Blair Trujillo, Silvia
Zuleta, Margarita
Carmona Fonseca, Jaime
Sáez Vega, Jairo Antonio
Tipo de recurso:
Article of investigation
Fecha de publicación:
2003
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/32014
Acceso en línea:
https://hdl.handle.net/10495/32014
Palabra clave:
Acetilación
Acetylation
Sustitución de Aminoácidos
Amino Acid Substitution
Antimaláricos
Antimalarials
Pruebas de Mutagenicidad
Mutagenicity Tests
Extractos Vegetales
Plant Extracts
Salmonella typhimurium
Compuestos de Espiro
Spiro Compounds
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_c082e549528c9a29dc458513fc6da36c
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/32014
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network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
title Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
spellingShingle Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
Acetilación
Acetylation
Sustitución de Aminoácidos
Amino Acid Substitution
Antimaláricos
Antimalarials
Pruebas de Mutagenicidad
Mutagenicity Tests
Extractos Vegetales
Plant Extracts
Salmonella typhimurium
Compuestos de Espiro
Spiro Compounds
title_short Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
title_full Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
title_fullStr Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
title_full_unstemmed Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
title_sort Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
dc.creator.fl_str_mv Pabón Vidal, Adriana Lucía
Blair Trujillo, Silvia
Zuleta, Margarita
Carmona Fonseca, Jaime
Sáez Vega, Jairo Antonio
dc.contributor.author.none.fl_str_mv Pabón Vidal, Adriana Lucía
Blair Trujillo, Silvia
Zuleta, Margarita
Carmona Fonseca, Jaime
Sáez Vega, Jairo Antonio
dc.subject.decs.none.fl_str_mv Acetilación
Acetylation
Sustitución de Aminoácidos
Amino Acid Substitution
Antimaláricos
Antimalarials
Pruebas de Mutagenicidad
Mutagenicity Tests
Extractos Vegetales
Plant Extracts
Salmonella typhimurium
Compuestos de Espiro
Spiro Compounds
topic Acetilación
Acetylation
Sustitución de Aminoácidos
Amino Acid Substitution
Antimaláricos
Antimalarials
Pruebas de Mutagenicidad
Mutagenicity Tests
Extractos Vegetales
Plant Extracts
Salmonella typhimurium
Compuestos de Espiro
Spiro Compounds
description ABSTRACT: Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extracts of Solanum nudum were tested for their mutagenic activity using the Ames test with the TA-97a, TA-98, TA-100 and TA-102 strains of Salmonella typhimurium. These compounds were not mutagenic at the tested concentrations.
publishDate 2003
dc.date.issued.none.fl_str_mv 2003
dc.date.accessioned.none.fl_str_mv 2022-11-13T19:31:26Z
dc.date.available.none.fl_str_mv 2022-11-13T19:31:26Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.local.spa.fl_str_mv Artículo de investigación
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dc.identifier.citation.spa.fl_str_mv Pabón A, Blair S, Carmona J, Zuleta M, Saez J. Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae). Pharmazie. 2003 Apr;58(4):263-7.
dc.identifier.issn.none.fl_str_mv 0031-7144
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/32014
identifier_str_mv Pabón A, Blair S, Carmona J, Zuleta M, Saez J. Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae). Pharmazie. 2003 Apr;58(4):263-7.
0031-7144
url https://hdl.handle.net/10495/32014
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Pharmazie.
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
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dc.rights.creativecommons.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.format.extent.spa.fl_str_mv 5
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dc.publisher.spa.fl_str_mv Govi-Verlag Pharmazautischer Verlag
dc.publisher.group.spa.fl_str_mv Grupo Malaria
dc.publisher.place.spa.fl_str_mv Berlín, Alemania
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/32014/4/BlairSilvia_2003_EvaluationMutagenicityAntimalarial.pdf
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spelling Pabón Vidal, Adriana LucíaBlair Trujillo, SilviaZuleta, MargaritaCarmona Fonseca, JaimeSáez Vega, Jairo Antonio2022-11-13T19:31:26Z2022-11-13T19:31:26Z2003Pabón A, Blair S, Carmona J, Zuleta M, Saez J. Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae). Pharmazie. 2003 Apr;58(4):263-7.0031-7144https://hdl.handle.net/10495/32014ABSTRACT: Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extracts of Solanum nudum were tested for their mutagenic activity using the Ames test with the TA-97a, TA-98, TA-100 and TA-102 strains of Salmonella typhimurium. These compounds were not mutagenic at the tested concentrations.COL00075245application/pdfengGovi-Verlag Pharmazautischer VerlagGrupo MalariaBerlín, Alemaniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)AcetilaciónAcetylationSustitución de AminoácidosAmino Acid SubstitutionAntimaláricosAntimalarialsPruebas de MutagenicidadMutagenicity TestsExtractos VegetalesPlant ExtractsSalmonella typhimuriumCompuestos de EspiroSpiro CompoundsPharmazie.Die Pharmazie263267584ORIGINALBlairSilvia_2003_EvaluationMutagenicityAntimalarial.pdfBlairSilvia_2003_EvaluationMutagenicityAntimalarial.pdfArtículo de investigaciónapplication/pdf98195https://bibliotecadigital.udea.edu.co/bitstream/10495/32014/4/BlairSilvia_2003_EvaluationMutagenicityAntimalarial.pdf62dfbf46f05fef5bf1779720190e2e24MD54CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/32014/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/32014/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/32014oai:bibliotecadigital.udea.edu.co:10495/320142022-11-13 14:34:21.664Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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