Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)

ABSTRACT: Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extracts of Solanum nudum were tested for their mutagenic activity using the Ames test with the TA-97a, TA-98, TA-100 and TA-102 strains of Salmonella typhimurium. These compounds were not mutagenic at the tested concentrations.

• Autores: Pabón Vidal, Adriana Lucía; Blair Trujillo, Silvia; Zuleta, Margarita; Carmona Fonseca, Jaime; Sáez Vega, Jairo Antonio
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2003
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/32014
• Acceso en línea: https://hdl.handle.net/10495/32014
• Palabra clave: Acetilación; Acetylation; Sustitución de Aminoácidos; Amino Acid Substitution; Antimaláricos; Antimalarials; Pruebas de Mutagenicidad; Mutagenicity Tests; Extractos Vegetales; Plant Extracts; Salmonella typhimurium; Compuestos de Espiro; Spiro Compounds
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/