Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)

ABSTRACT : In paracoccidioidomycosis (PCM), the primary lung infection remains silent. In this study, attempts weredone to define the primary target organ by correlating lung radiographic abnormalities with the time course of mucosal/skin lesions concurrently exhibited at diagnosis by 63 patients in...

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Autores:
Restrepo Moreno, Ángela
Tobón Orozco, Ángela María
Agudelo Restrepo, Carlos Andrés
Ochoa Múnera, Juan Eugenio
Rosero, David Santiago
Osorio, Marta Lucía
Cano Restrepo, Luz Elena
Álvarez, Diego Luis
Tipo de recurso:
Article of investigation
Fecha de publicación:
2008
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/20568
Acceso en línea:
http://hdl.handle.net/10495/20568
Palabra clave:
Paracoccidioidomicosis
Paracoccidioidomycosis
Paracoccidioides
Rights
openAccess
License
https://creativecommons.org/licenses/by/2.5/co/
id UDEA2_bdc9590779a81bcd405efcc24d208d3f
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/20568
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
title Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
spellingShingle Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
Paracoccidioidomicosis
Paracoccidioidomycosis
Paracoccidioides
title_short Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
title_full Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
title_fullStr Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
title_full_unstemmed Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
title_sort Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
dc.creator.fl_str_mv Restrepo Moreno, Ángela
Tobón Orozco, Ángela María
Agudelo Restrepo, Carlos Andrés
Ochoa Múnera, Juan Eugenio
Rosero, David Santiago
Osorio, Marta Lucía
Cano Restrepo, Luz Elena
Álvarez, Diego Luis
dc.contributor.author.none.fl_str_mv Restrepo Moreno, Ángela
Tobón Orozco, Ángela María
Agudelo Restrepo, Carlos Andrés
Ochoa Múnera, Juan Eugenio
Rosero, David Santiago
Osorio, Marta Lucía
Cano Restrepo, Luz Elena
Álvarez, Diego Luis
dc.subject.decs.none.fl_str_mv Paracoccidioidomicosis
Paracoccidioidomycosis
Paracoccidioides
topic Paracoccidioidomicosis
Paracoccidioidomycosis
Paracoccidioides
description ABSTRACT : In paracoccidioidomycosis (PCM), the primary lung infection remains silent. In this study, attempts weredone to define the primary target organ by correlating lung radiographic abnormalities with the time course of mucosal/skin lesions concurrently exhibited at diagnosis by 63 patients in whom microscopy and/or isolation ofParacoccidioidesbrasiliensisfrom respiratory secretions had been positive. Mucosal and skin lesions were found in 65.1% and 12.7% ofthe patients, respectively. Odynophagia and dysphagia were present in 38.1% each. All patients had lung interstitialinfiltrates, and 31.7% had also alveolar lesions; fibrosis was recorded in 46% of them. An inverse correlation was shownfor fibrosis and presence of either odynophagia or dysphagia. Cluster analyzes strongly supported two sets of patients:those with mucosal damage, odynophagia/dysphagia, and alveolo-interstitial infiltrates and those with dermal lesions,dyspnea, and lung fibrosis. These groups may represent novel stages in the natural course of PCM.
publishDate 2008
dc.date.issued.none.fl_str_mv 2008
dc.date.accessioned.none.fl_str_mv 2021-07-01T20:20:25Z
dc.date.available.none.fl_str_mv 2021-07-01T20:20:25Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.type.local.spa.fl_str_mv Artículo de investigación
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dc.identifier.citation.spa.fl_str_mv Restrepo, A., Tobón, A. M., Agudelo, C. A., Ochoa, J. E., Rosero, D. S., Osorio, M. L., Cano, L. E., & Alvarez, D. L. (2008). Co-existence of Integumentary Lesions and Lung X-ray Abnormalities in Patients with Paracoccidioidomycosis (PCM), The American Journal of Tropical Medicine and Hygiene Am J Trop Med Hyg, 79(2), 159-163. Retrieved Jul 29, 2021, from https://www.ajtmh.org/view/journals/tpmd/79/2/article-p159.xml
dc.identifier.issn.none.fl_str_mv 0002-9637
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/20568
dc.identifier.doi.none.fl_str_mv 10.4269/ajtmh.2008.79.159
dc.identifier.eissn.none.fl_str_mv 1476-1645
identifier_str_mv Restrepo, A., Tobón, A. M., Agudelo, C. A., Ochoa, J. E., Rosero, D. S., Osorio, M. L., Cano, L. E., & Alvarez, D. L. (2008). Co-existence of Integumentary Lesions and Lung X-ray Abnormalities in Patients with Paracoccidioidomycosis (PCM), The American Journal of Tropical Medicine and Hygiene Am J Trop Med Hyg, 79(2), 159-163. Retrieved Jul 29, 2021, from https://www.ajtmh.org/view/journals/tpmd/79/2/article-p159.xml
0002-9637
10.4269/ajtmh.2008.79.159
1476-1645
url http://hdl.handle.net/10495/20568
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Am. j. trop. med. hyg.
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/co/
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dc.publisher.spa.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.publisher.group.spa.fl_str_mv Micología Médica y Experimental
Microbiología Molecular
Biología Celular y Molecular CIB, U. de A. U. del Rosario
dc.publisher.place.spa.fl_str_mv Baltimore, Estados Unidos
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/20568/1/RestrepoAngela_2008_IntegumentaryLesionsParacoccidioidomycosis.pdf
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repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
repository.mail.fl_str_mv andres.perez@udea.edu.co
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spelling Restrepo Moreno, ÁngelaTobón Orozco, Ángela MaríaAgudelo Restrepo, Carlos AndrésOchoa Múnera, Juan EugenioRosero, David SantiagoOsorio, Marta LucíaCano Restrepo, Luz ElenaÁlvarez, Diego Luis2021-07-01T20:20:25Z2021-07-01T20:20:25Z2008Restrepo, A., Tobón, A. M., Agudelo, C. A., Ochoa, J. E., Rosero, D. S., Osorio, M. L., Cano, L. E., & Alvarez, D. L. (2008). Co-existence of Integumentary Lesions and Lung X-ray Abnormalities in Patients with Paracoccidioidomycosis (PCM), The American Journal of Tropical Medicine and Hygiene Am J Trop Med Hyg, 79(2), 159-163. Retrieved Jul 29, 2021, from https://www.ajtmh.org/view/journals/tpmd/79/2/article-p159.xml0002-9637http://hdl.handle.net/10495/2056810.4269/ajtmh.2008.79.1591476-1645ABSTRACT : In paracoccidioidomycosis (PCM), the primary lung infection remains silent. In this study, attempts weredone to define the primary target organ by correlating lung radiographic abnormalities with the time course of mucosal/skin lesions concurrently exhibited at diagnosis by 63 patients in whom microscopy and/or isolation ofParacoccidioidesbrasiliensisfrom respiratory secretions had been positive. Mucosal and skin lesions were found in 65.1% and 12.7% ofthe patients, respectively. Odynophagia and dysphagia were present in 38.1% each. All patients had lung interstitialinfiltrates, and 31.7% had also alveolar lesions; fibrosis was recorded in 46% of them. An inverse correlation was shownfor fibrosis and presence of either odynophagia or dysphagia. Cluster analyzes strongly supported two sets of patients:those with mucosal damage, odynophagia/dysphagia, and alveolo-interstitial infiltrates and those with dermal lesions,dyspnea, and lung fibrosis. These groups may represent novel stages in the natural course of PCM.COL0013709COL0013746COL00009625application/pdfengAmerican Society of Tropical Medicine and HygieneMicología Médica y ExperimentalMicrobiología MolecularBiología Celular y Molecular CIB, U. de A. U. del RosarioBaltimore, Estados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)ParacoccidioidomicosisParacoccidioidomycosisParacoccidioidesAm. j. trop. med. hyg.American Journal of Tropical Medicine and Hygiene159163792ORIGINALRestrepoAngela_2008_IntegumentaryLesionsParacoccidioidomycosis.pdfRestrepoAngela_2008_IntegumentaryLesionsParacoccidioidomycosis.pdfArtículo de investigaciónapplication/pdf167639https://bibliotecadigital.udea.edu.co/bitstream/10495/20568/1/RestrepoAngela_2008_IntegumentaryLesionsParacoccidioidomycosis.pdfb96d505465c3f1c371b68415f7b08492MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/20568/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5210495/20568oai:bibliotecadigital.udea.edu.co:10495/205682022-04-22 10:18:00.872Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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