Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)
ABSTRACT : In paracoccidioidomycosis (PCM), the primary lung infection remains silent. In this study, attempts weredone to define the primary target organ by correlating lung radiographic abnormalities with the time course of mucosal/skin lesions concurrently exhibited at diagnosis by 63 patients in...
- Autores:
-
Restrepo Moreno, Ángela
Tobón Orozco, Ángela María
Agudelo Restrepo, Carlos Andrés
Ochoa Múnera, Juan Eugenio
Rosero, David Santiago
Osorio, Marta Lucía
Cano Restrepo, Luz Elena
Álvarez, Diego Luis
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2008
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/20568
- Acceso en línea:
- http://hdl.handle.net/10495/20568
- Palabra clave:
- Paracoccidioidomicosis
Paracoccidioidomycosis
Paracoccidioides
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/2.5/co/
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|
dc.title.spa.fl_str_mv |
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM) |
title |
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM) |
spellingShingle |
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM) Paracoccidioidomicosis Paracoccidioidomycosis Paracoccidioides |
title_short |
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM) |
title_full |
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM) |
title_fullStr |
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM) |
title_full_unstemmed |
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM) |
title_sort |
Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM) |
dc.creator.fl_str_mv |
Restrepo Moreno, Ángela Tobón Orozco, Ángela María Agudelo Restrepo, Carlos Andrés Ochoa Múnera, Juan Eugenio Rosero, David Santiago Osorio, Marta Lucía Cano Restrepo, Luz Elena Álvarez, Diego Luis |
dc.contributor.author.none.fl_str_mv |
Restrepo Moreno, Ángela Tobón Orozco, Ángela María Agudelo Restrepo, Carlos Andrés Ochoa Múnera, Juan Eugenio Rosero, David Santiago Osorio, Marta Lucía Cano Restrepo, Luz Elena Álvarez, Diego Luis |
dc.subject.decs.none.fl_str_mv |
Paracoccidioidomicosis Paracoccidioidomycosis Paracoccidioides |
topic |
Paracoccidioidomicosis Paracoccidioidomycosis Paracoccidioides |
description |
ABSTRACT : In paracoccidioidomycosis (PCM), the primary lung infection remains silent. In this study, attempts weredone to define the primary target organ by correlating lung radiographic abnormalities with the time course of mucosal/skin lesions concurrently exhibited at diagnosis by 63 patients in whom microscopy and/or isolation ofParacoccidioidesbrasiliensisfrom respiratory secretions had been positive. Mucosal and skin lesions were found in 65.1% and 12.7% ofthe patients, respectively. Odynophagia and dysphagia were present in 38.1% each. All patients had lung interstitialinfiltrates, and 31.7% had also alveolar lesions; fibrosis was recorded in 46% of them. An inverse correlation was shownfor fibrosis and presence of either odynophagia or dysphagia. Cluster analyzes strongly supported two sets of patients:those with mucosal damage, odynophagia/dysphagia, and alveolo-interstitial infiltrates and those with dermal lesions,dyspnea, and lung fibrosis. These groups may represent novel stages in the natural course of PCM. |
publishDate |
2008 |
dc.date.issued.none.fl_str_mv |
2008 |
dc.date.accessioned.none.fl_str_mv |
2021-07-01T20:20:25Z |
dc.date.available.none.fl_str_mv |
2021-07-01T20:20:25Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.citation.spa.fl_str_mv |
Restrepo, A., Tobón, A. M., Agudelo, C. A., Ochoa, J. E., Rosero, D. S., Osorio, M. L., Cano, L. E., & Alvarez, D. L. (2008). Co-existence of Integumentary Lesions and Lung X-ray Abnormalities in Patients with Paracoccidioidomycosis (PCM), The American Journal of Tropical Medicine and Hygiene Am J Trop Med Hyg, 79(2), 159-163. Retrieved Jul 29, 2021, from https://www.ajtmh.org/view/journals/tpmd/79/2/article-p159.xml |
dc.identifier.issn.none.fl_str_mv |
0002-9637 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/20568 |
dc.identifier.doi.none.fl_str_mv |
10.4269/ajtmh.2008.79.159 |
dc.identifier.eissn.none.fl_str_mv |
1476-1645 |
identifier_str_mv |
Restrepo, A., Tobón, A. M., Agudelo, C. A., Ochoa, J. E., Rosero, D. S., Osorio, M. L., Cano, L. E., & Alvarez, D. L. (2008). Co-existence of Integumentary Lesions and Lung X-ray Abnormalities in Patients with Paracoccidioidomycosis (PCM), The American Journal of Tropical Medicine and Hygiene Am J Trop Med Hyg, 79(2), 159-163. Retrieved Jul 29, 2021, from https://www.ajtmh.org/view/journals/tpmd/79/2/article-p159.xml 0002-9637 10.4269/ajtmh.2008.79.159 1476-1645 |
url |
http://hdl.handle.net/10495/20568 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Am. j. trop. med. hyg. |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
https://creativecommons.org/licenses/by/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
dc.publisher.group.spa.fl_str_mv |
Micología Médica y Experimental Microbiología Molecular Biología Celular y Molecular CIB, U. de A. U. del Rosario |
dc.publisher.place.spa.fl_str_mv |
Baltimore, Estados Unidos |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstream/10495/20568/1/RestrepoAngela_2008_IntegumentaryLesionsParacoccidioidomycosis.pdf https://bibliotecadigital.udea.edu.co/bitstream/10495/20568/2/license.txt |
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bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
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1812173288716107776 |
spelling |
Restrepo Moreno, ÁngelaTobón Orozco, Ángela MaríaAgudelo Restrepo, Carlos AndrésOchoa Múnera, Juan EugenioRosero, David SantiagoOsorio, Marta LucíaCano Restrepo, Luz ElenaÁlvarez, Diego Luis2021-07-01T20:20:25Z2021-07-01T20:20:25Z2008Restrepo, A., Tobón, A. M., Agudelo, C. A., Ochoa, J. E., Rosero, D. S., Osorio, M. L., Cano, L. E., & Alvarez, D. L. (2008). Co-existence of Integumentary Lesions and Lung X-ray Abnormalities in Patients with Paracoccidioidomycosis (PCM), The American Journal of Tropical Medicine and Hygiene Am J Trop Med Hyg, 79(2), 159-163. Retrieved Jul 29, 2021, from https://www.ajtmh.org/view/journals/tpmd/79/2/article-p159.xml0002-9637http://hdl.handle.net/10495/2056810.4269/ajtmh.2008.79.1591476-1645ABSTRACT : In paracoccidioidomycosis (PCM), the primary lung infection remains silent. In this study, attempts weredone to define the primary target organ by correlating lung radiographic abnormalities with the time course of mucosal/skin lesions concurrently exhibited at diagnosis by 63 patients in whom microscopy and/or isolation ofParacoccidioidesbrasiliensisfrom respiratory secretions had been positive. Mucosal and skin lesions were found in 65.1% and 12.7% ofthe patients, respectively. Odynophagia and dysphagia were present in 38.1% each. All patients had lung interstitialinfiltrates, and 31.7% had also alveolar lesions; fibrosis was recorded in 46% of them. An inverse correlation was shownfor fibrosis and presence of either odynophagia or dysphagia. Cluster analyzes strongly supported two sets of patients:those with mucosal damage, odynophagia/dysphagia, and alveolo-interstitial infiltrates and those with dermal lesions,dyspnea, and lung fibrosis. These groups may represent novel stages in the natural course of PCM.COL0013709COL0013746COL00009625application/pdfengAmerican Society of Tropical Medicine and HygieneMicología Médica y ExperimentalMicrobiología MolecularBiología Celular y Molecular CIB, U. de A. U. del RosarioBaltimore, Estados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Co-existence of integumentary lesions and lung x-ray abnormalities in patients with paracoccidioidomycosis (PCM)ParacoccidioidomicosisParacoccidioidomycosisParacoccidioidesAm. j. trop. med. hyg.American Journal of Tropical Medicine and Hygiene159163792ORIGINALRestrepoAngela_2008_IntegumentaryLesionsParacoccidioidomycosis.pdfRestrepoAngela_2008_IntegumentaryLesionsParacoccidioidomycosis.pdfArtículo de investigaciónapplication/pdf167639https://bibliotecadigital.udea.edu.co/bitstream/10495/20568/1/RestrepoAngela_2008_IntegumentaryLesionsParacoccidioidomycosis.pdfb96d505465c3f1c371b68415f7b08492MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/20568/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5210495/20568oai:bibliotecadigital.udea.edu.co:10495/205682022-04-22 10:18:00.872Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |