Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
ABSTRACT: Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on hu...
- Autores:
-
Marín Echeverri, Catalina
Blesso, Christopher N.
Fernández, María Luz
Galvis Pérez, Yeisson
Ciro Gómez, Gelmy Luz
Núñez Rangel, Vitelbina
Aristizábal Rivera, Juan Carlos
Barona Acevedo, Jacqueline
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11639
- Acceso en línea:
- http://hdl.handle.net/10495/11639
- Palabra clave:
- Andean berry
Cardiovascular risk factors
HDL dysfunction
Inflammation
Oxidative stress
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/2.5/co/
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|
dc.title.spa.fl_str_mv |
Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome |
title |
Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome |
spellingShingle |
Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome Andean berry Cardiovascular risk factors HDL dysfunction Inflammation Oxidative stress |
title_short |
Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome |
title_full |
Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome |
title_fullStr |
Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome |
title_full_unstemmed |
Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome |
title_sort |
Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome |
dc.creator.fl_str_mv |
Marín Echeverri, Catalina Blesso, Christopher N. Fernández, María Luz Galvis Pérez, Yeisson Ciro Gómez, Gelmy Luz Núñez Rangel, Vitelbina Aristizábal Rivera, Juan Carlos Barona Acevedo, Jacqueline |
dc.contributor.author.none.fl_str_mv |
Marín Echeverri, Catalina Blesso, Christopher N. Fernández, María Luz Galvis Pérez, Yeisson Ciro Gómez, Gelmy Luz Núñez Rangel, Vitelbina Aristizábal Rivera, Juan Carlos Barona Acevedo, Jacqueline |
dc.subject.none.fl_str_mv |
Andean berry Cardiovascular risk factors HDL dysfunction Inflammation Oxidative stress |
topic |
Andean berry Cardiovascular risk factors HDL dysfunction Inflammation Oxidative stress |
description |
ABSTRACT: Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25–60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period. HDL function (apoliprotein-A1; paraoxonase 1 (PON1) activity; cholesterol efflux capacity), oxidative stress (myeloperoxidase (MPO), advanced oxidation protein products) and inflammatory markers (serum cytokines/chemokines and peripheral blood mononuclear cell nuclear factor-kB) were measured after each period. Compared to placebo, agraz consumption did not significantly change any of the biomarkers measured. Interestingly, only after agraz period there were significant positive correlations between PON1 activities and cholesterol efflux. Additionally, there were significant inverse correlations between changes in inflammatory markers and HDL function markers and positive correlations with oxidative markers. Although polyphenol-rich foods have been shown to be beneficial for certain conditions; polyphenol-rich agraz fruit consumption did not impact inflammation and HDL function in the current study of women with MetS. |
publishDate |
2018 |
dc.date.issued.none.fl_str_mv |
2018 |
dc.date.accessioned.none.fl_str_mv |
2019-08-12T21:50:17Z |
dc.date.available.none.fl_str_mv |
2019-08-12T21:50:17Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/CJournalArticle |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.citation.spa.fl_str_mv |
Marín C, Blesso C, Fernández M, Galvis Y, Ciro G, et al. Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome. Antioxidants. 2018; 7(12), 185. DOI:10.3390/antiox7120185 |
dc.identifier.issn.none.fl_str_mv |
2076-3921 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/11639 |
dc.identifier.doi.none.fl_str_mv |
10.3390/antiox7120185 |
identifier_str_mv |
Marín C, Blesso C, Fernández M, Galvis Y, Ciro G, et al. Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome. Antioxidants. 2018; 7(12), 185. DOI:10.3390/antiox7120185 2076-3921 10.3390/antiox7120185 |
url |
http://hdl.handle.net/10495/11639 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Antioxidants |
dc.rights.*.fl_str_mv |
https://creativecommons.org/licenses/by/2.5/co/ |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
https://creativecommons.org/licenses/by/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
MDPI (Multidisciplinary Digital Publishing Institute) |
dc.publisher.group.spa.fl_str_mv |
Grupo de Investigación en Fisiología y Bioquímica - Physis Toxinología, Alternativas Terapéuticas y Alimentarias |
dc.publisher.place.spa.fl_str_mv |
Basilea, Suiza |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstream/10495/11639/3/MarinCatalina_2018_EffectAgrazHigh-Density.pdf https://bibliotecadigital.udea.edu.co/bitstream/10495/11639/4/license.txt |
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MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
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1812173107739230208 |
spelling |
Marín Echeverri, CatalinaBlesso, Christopher N.Fernández, María LuzGalvis Pérez, YeissonCiro Gómez, Gelmy LuzNúñez Rangel, VitelbinaAristizábal Rivera, Juan CarlosBarona Acevedo, Jacqueline2019-08-12T21:50:17Z2019-08-12T21:50:17Z2018Marín C, Blesso C, Fernández M, Galvis Y, Ciro G, et al. Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome. Antioxidants. 2018; 7(12), 185. DOI:10.3390/antiox71201852076-3921http://hdl.handle.net/10495/1163910.3390/antiox7120185ABSTRACT: Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25–60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period. HDL function (apoliprotein-A1; paraoxonase 1 (PON1) activity; cholesterol efflux capacity), oxidative stress (myeloperoxidase (MPO), advanced oxidation protein products) and inflammatory markers (serum cytokines/chemokines and peripheral blood mononuclear cell nuclear factor-kB) were measured after each period. Compared to placebo, agraz consumption did not significantly change any of the biomarkers measured. Interestingly, only after agraz period there were significant positive correlations between PON1 activities and cholesterol efflux. Additionally, there were significant inverse correlations between changes in inflammatory markers and HDL function markers and positive correlations with oxidative markers. Although polyphenol-rich foods have been shown to be beneficial for certain conditions; polyphenol-rich agraz fruit consumption did not impact inflammation and HDL function in the current study of women with MetS.COL0014476COL0007328application/pdfengMDPI (Multidisciplinary Digital Publishing Institute)Grupo de Investigación en Fisiología y Bioquímica - PhysisToxinología, Alternativas Terapéuticas y AlimentariasBasilea, Suizainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/redcol/resource_type/CJournalArticleArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85https://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Andean berryCardiovascular risk factorsHDL dysfunctionInflammationOxidative stressEffect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndromeAntioxidantsAntioxidants1147ORIGINALMarinCatalina_2018_EffectAgrazHigh-Density.pdfMarinCatalina_2018_EffectAgrazHigh-Density.pdfArtículo de investigaciónapplication/pdf2442898https://bibliotecadigital.udea.edu.co/bitstream/10495/11639/3/MarinCatalina_2018_EffectAgrazHigh-Density.pdf4c383f9e09fd56e14a7491595b854f69MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/11639/4/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5410495/11639oai:bibliotecadigital.udea.edu.co:10495/116392022-11-18 10:20:25.536Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |