Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome

ABSTRACT: Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on hu...

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Autores:
Marín Echeverri, Catalina
Blesso, Christopher N.
Fernández, María Luz
Galvis Pérez, Yeisson
Ciro Gómez, Gelmy Luz
Núñez Rangel, Vitelbina
Aristizábal Rivera, Juan Carlos
Barona Acevedo, Jacqueline
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/11639
Acceso en línea:
http://hdl.handle.net/10495/11639
Palabra clave:
Andean berry
Cardiovascular risk factors
HDL dysfunction
Inflammation
Oxidative stress
Rights
openAccess
License
https://creativecommons.org/licenses/by/2.5/co/
id UDEA2_ba792b9d492b25c5255b608f5865ad69
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/11639
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
title Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
spellingShingle Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
Andean berry
Cardiovascular risk factors
HDL dysfunction
Inflammation
Oxidative stress
title_short Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
title_full Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
title_fullStr Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
title_full_unstemmed Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
title_sort Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome
dc.creator.fl_str_mv Marín Echeverri, Catalina
Blesso, Christopher N.
Fernández, María Luz
Galvis Pérez, Yeisson
Ciro Gómez, Gelmy Luz
Núñez Rangel, Vitelbina
Aristizábal Rivera, Juan Carlos
Barona Acevedo, Jacqueline
dc.contributor.author.none.fl_str_mv Marín Echeverri, Catalina
Blesso, Christopher N.
Fernández, María Luz
Galvis Pérez, Yeisson
Ciro Gómez, Gelmy Luz
Núñez Rangel, Vitelbina
Aristizábal Rivera, Juan Carlos
Barona Acevedo, Jacqueline
dc.subject.none.fl_str_mv Andean berry
Cardiovascular risk factors
HDL dysfunction
Inflammation
Oxidative stress
topic Andean berry
Cardiovascular risk factors
HDL dysfunction
Inflammation
Oxidative stress
description ABSTRACT: Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25–60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period. HDL function (apoliprotein-A1; paraoxonase 1 (PON1) activity; cholesterol efflux capacity), oxidative stress (myeloperoxidase (MPO), advanced oxidation protein products) and inflammatory markers (serum cytokines/chemokines and peripheral blood mononuclear cell nuclear factor-kB) were measured after each period. Compared to placebo, agraz consumption did not significantly change any of the biomarkers measured. Interestingly, only after agraz period there were significant positive correlations between PON1 activities and cholesterol efflux. Additionally, there were significant inverse correlations between changes in inflammatory markers and HDL function markers and positive correlations with oxidative markers. Although polyphenol-rich foods have been shown to be beneficial for certain conditions; polyphenol-rich agraz fruit consumption did not impact inflammation and HDL function in the current study of women with MetS.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2019-08-12T21:50:17Z
dc.date.available.none.fl_str_mv 2019-08-12T21:50:17Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/CJournalArticle
dc.type.local.spa.fl_str_mv Artículo de investigación
format http://purl.org/coar/resource_type/c_6501
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dc.identifier.citation.spa.fl_str_mv Marín C, Blesso C, Fernández M, Galvis Y, Ciro G, et al. Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome. Antioxidants. 2018; 7(12), 185. DOI:10.3390/antiox7120185
dc.identifier.issn.none.fl_str_mv 2076-3921
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/11639
dc.identifier.doi.none.fl_str_mv 10.3390/antiox7120185
identifier_str_mv Marín C, Blesso C, Fernández M, Galvis Y, Ciro G, et al. Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome. Antioxidants. 2018; 7(12), 185. DOI:10.3390/antiox7120185
2076-3921
10.3390/antiox7120185
url http://hdl.handle.net/10495/11639
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Antioxidants
dc.rights.*.fl_str_mv https://creativecommons.org/licenses/by/2.5/co/
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv https://creativecommons.org/licenses/by/2.5/co/
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http://purl.org/coar/access_right/c_abf2
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eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv MDPI (Multidisciplinary Digital Publishing Institute)
dc.publisher.group.spa.fl_str_mv Grupo de Investigación en Fisiología y Bioquímica - Physis
Toxinología, Alternativas Terapéuticas y Alimentarias
dc.publisher.place.spa.fl_str_mv Basilea, Suiza
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/11639/3/MarinCatalina_2018_EffectAgrazHigh-Density.pdf
https://bibliotecadigital.udea.edu.co/bitstream/10495/11639/4/license.txt
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spelling Marín Echeverri, CatalinaBlesso, Christopher N.Fernández, María LuzGalvis Pérez, YeissonCiro Gómez, Gelmy LuzNúñez Rangel, VitelbinaAristizábal Rivera, Juan CarlosBarona Acevedo, Jacqueline2019-08-12T21:50:17Z2019-08-12T21:50:17Z2018Marín C, Blesso C, Fernández M, Galvis Y, Ciro G, et al. Effect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndrome. Antioxidants. 2018; 7(12), 185. DOI:10.3390/antiox71201852076-3921http://hdl.handle.net/10495/1163910.3390/antiox7120185ABSTRACT: Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25–60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period. HDL function (apoliprotein-A1; paraoxonase 1 (PON1) activity; cholesterol efflux capacity), oxidative stress (myeloperoxidase (MPO), advanced oxidation protein products) and inflammatory markers (serum cytokines/chemokines and peripheral blood mononuclear cell nuclear factor-kB) were measured after each period. Compared to placebo, agraz consumption did not significantly change any of the biomarkers measured. Interestingly, only after agraz period there were significant positive correlations between PON1 activities and cholesterol efflux. Additionally, there were significant inverse correlations between changes in inflammatory markers and HDL function markers and positive correlations with oxidative markers. Although polyphenol-rich foods have been shown to be beneficial for certain conditions; polyphenol-rich agraz fruit consumption did not impact inflammation and HDL function in the current study of women with MetS.COL0014476COL0007328application/pdfengMDPI (Multidisciplinary Digital Publishing Institute)Grupo de Investigación en Fisiología y Bioquímica - PhysisToxinología, Alternativas Terapéuticas y AlimentariasBasilea, Suizainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/redcol/resource_type/CJournalArticleArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85https://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Andean berryCardiovascular risk factorsHDL dysfunctionInflammationOxidative stressEffect of Agraz (Vaccinium meridionale Swartz) on high-density lipoprotein function and inflammation in women with metabolic syndromeAntioxidantsAntioxidants1147ORIGINALMarinCatalina_2018_EffectAgrazHigh-Density.pdfMarinCatalina_2018_EffectAgrazHigh-Density.pdfArtículo de investigaciónapplication/pdf2442898https://bibliotecadigital.udea.edu.co/bitstream/10495/11639/3/MarinCatalina_2018_EffectAgrazHigh-Density.pdf4c383f9e09fd56e14a7491595b854f69MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/11639/4/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5410495/11639oai:bibliotecadigital.udea.edu.co:10495/116392022-11-18 10:20:25.536Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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