Señales moleculares que afectan la síntesis de PGF2a y PGE2 en el endometrio bovino

ABSTRACT: The bovine endometrial tissue contains two cell biotypes with different morphophysiological characteristics: Endometrial Epithelial Cells (EEPC) and Endometrial Stromal Cells (EESC). Female cycle is determined, among other factors, by the functionality and durability of the corpus luteum (CL), which secretes progesterone (P4) for the maintenance of pregnancy. Regulation of CL is mediated by Series 2 prostaglandins, mostly PGF2α and PGE2. The main factor is luteolytic PGF2α, whereas PGE2 stimulates and promotes luteotrophic effects. Several molecules modulate the synthesis of PGF2α and PGE2 in bovine endometrium, such as interferon-τau, oxytocin, estrogen, arachidonic acid (AA) and linoleic acid (LA), among others. The study of synthesis regulation of these prostaglandins is important to advance the understanding of reproductive events, allowing to develop technologies for manipulating the estrous cycle in cattle. The purpose of this review is to describe the major stimuli and molecular mechanisms that affect the synthesis of PGF2α and PGE2 in bovine endometrium, and their effects on embryo maternal recognition window.

• Autores: Lenis Sanín, Yasser Yohan; Olivera Ángel, Martha; Tarazona Morales, Ariel Marcel
• Tipo de recurso: Review article
• Fecha de publicación: 2010
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: spa
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/8450
• Acceso en línea: http://hdl.handle.net/10495/8450
• Palabra clave: Ácido araquidónico; Ácido linoléico; Cuerpo lúteo; Oxitocina; Prostaglandinas
• Rights: openAccess
• License: Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)