New 1,4-anthracenedione derivatives with fused heterocyclic rings: Synthesis and biological evaluation

ABSTARCT: Several terpenylquinones derived from 1,4-anthracenedione (1,4-anthracenequinone, AQ) have been prepared by addition or substitution nucleophilic reactions and further transformed into extended polycyclic systems, which mainly kept the 1,4-quinone moiety fused to different nitrogen-heterocyclic rings (pyrrole, imidazole, pyrazine or quinoxaline) into the structure. The compounds synthesized were evaluated for their antineoplastic, antifungal and antiviral activities. GI50 antineoplastic values remained under μM levels for AQs, while the heterocyclic derivatives showed antifungal MIC values in the low μg mL-1 range against yeasts and filamentous fungi. Only few compounds displayed a discrete non-selective antiherpetic activity in the μg mL-1 range. This journal is © The Royal Society of Chemistry 2015.

• Autores: Roa Linares, Vicky Constanza; Gamito, Ana Maria; Castro, Maria Angeles; Mesa Arango, Ana Cecilia; Martin, Arturo San Feliciano; Tangarife Castano, Veronica; Betancur Galvis, Liliana Amparo; Del Corral, Jose Maria Migel; Francesch, Andres
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2015
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/11490
• Acceso en línea: http://hdl.handle.net/10495/11490
• Palabra clave: Organic compounds; Antineoplastic; Antiviral activities; Biological evaluation; Filamentous fungi; Heterocyclic rings; Nucleophilic reaction; Polycyclic systems; Quinoxalines
• Rights: openAccess
• License: Atribución 2.5