Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA

ABSTRACT : Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to sequence type 512 (ST512) (o...

Full description

Autores:
Cienfuegos Gallet, Astrid Vanessa
Chen, Liang
Kreiswirth, Barry
Jimenes Quiceno, Judy Natalia
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/20639
Acceso en línea:
http://hdl.handle.net/10495/20639
Palabra clave:
Klebsiella pneumoniae
Colistina
Colistin
Enterobacteriaceae Resistentes a los Carbapenémicos
Carbapenem-Resistant Enterobacteriaceae
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
Description
Summary:ABSTRACT : Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to ISKpn25, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting that the colistin resistance is mediated by chromosomal integration of plasmid DNA.