Efecto inmunomodulador de nanopartículas usadas en nanomedicina
ABSTRACT: Nanoparticles (NP) are structures with a size on the nanometer scale (1 x 10-9 m). Due to their characteristics, their potential use in the fields of biotechnology and biomedicine has grown in recent years with a wide range of applications, such as diagnosis, therapy and regenerative medic...
- Autores:
-
Gómez Gallego, Diana Maryory
Urcuqui Inchima, Silvio
Hernández López, Juan Carlos
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11633
- Acceso en línea:
- http://hdl.handle.net/10495/11633
- Palabra clave:
- Inmunomodulación
Nanomedicina
Nanopartículas
Terapia Inmunomoduladora
Nanoteranóstica
Sistema inmunológico
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
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Efecto inmunomodulador de nanopartículas usadas en nanomedicina |
| title |
Efecto inmunomodulador de nanopartículas usadas en nanomedicina |
| spellingShingle |
Efecto inmunomodulador de nanopartículas usadas en nanomedicina Inmunomodulación Nanomedicina Nanopartículas Terapia Inmunomoduladora Nanoteranóstica Sistema inmunológico |
| title_short |
Efecto inmunomodulador de nanopartículas usadas en nanomedicina |
| title_full |
Efecto inmunomodulador de nanopartículas usadas en nanomedicina |
| title_fullStr |
Efecto inmunomodulador de nanopartículas usadas en nanomedicina |
| title_full_unstemmed |
Efecto inmunomodulador de nanopartículas usadas en nanomedicina |
| title_sort |
Efecto inmunomodulador de nanopartículas usadas en nanomedicina |
| dc.creator.fl_str_mv |
Gómez Gallego, Diana Maryory Urcuqui Inchima, Silvio Hernández López, Juan Carlos |
| dc.contributor.author.none.fl_str_mv |
Gómez Gallego, Diana Maryory Urcuqui Inchima, Silvio Hernández López, Juan Carlos |
| dc.subject.none.fl_str_mv |
Inmunomodulación Nanomedicina Nanopartículas Terapia Inmunomoduladora Nanoteranóstica Sistema inmunológico |
| topic |
Inmunomodulación Nanomedicina Nanopartículas Terapia Inmunomoduladora Nanoteranóstica Sistema inmunológico |
| description |
ABSTRACT: Nanoparticles (NP) are structures with a size on the nanometer scale (1 x 10-9 m). Due to their characteristics, their potential use in the fields of biotechnology and biomedicine has grown in recent years with a wide range of applications, such as diagnosis, therapy and regenerative medicine. The immune system is responsible for defending the body against pathogenic organisms and other foreign agents, such as NP, which can be recognized by such system, interact with it and modulate its function inducing immunostimulatory or immunosuppressive effects. The latter could be used as anti-inflammatory therapeutic agents or to treat autoimmune diseases, and those that activate the immune system, as adjuvants in vaccination or enhancers of the immune response in cancer and other human diseases. However, their use in nanomedicine should be submitted to preliminary tests to determine their effects on the immune response before being applied to biological systems. For this reason it is important to know their composition, size and surface characteristics, as well as other physicochemical properties, directly involved in the effects on the immune system. We present an overview about the relationship between the physicochemical characteristics of NP candidates to be used in the biomedical and biotechnological fields and their immunomodulatory activity. Key words: Immunomodulation; Nanomedicine; Nanoparticles. |
| publishDate |
2016 |
| dc.date.issued.none.fl_str_mv |
2016 |
| dc.date.accessioned.none.fl_str_mv |
2019-08-10T14:19:43Z |
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2019-08-10T14:19:43Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Gómez-Gallego DM, Urcuqui-Inchima S, Hernández JC. Efecto inmunomodulador de nanopartículas usadas en nanomedicina. Iatreia. 2016 Oct-Dic;29(4):445-457. DOI 10.17533/udea.iatreia.v29n4a06 |
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0121-0793 |
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http://hdl.handle.net/10495/11633 |
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10.17533/udea.iatreia.v29n4a06 |
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2011-7965 |
| identifier_str_mv |
Gómez-Gallego DM, Urcuqui-Inchima S, Hernández JC. Efecto inmunomodulador de nanopartículas usadas en nanomedicina. Iatreia. 2016 Oct-Dic;29(4):445-457. DOI 10.17533/udea.iatreia.v29n4a06 0121-0793 10.17533/udea.iatreia.v29n4a06 2011-7965 |
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http://hdl.handle.net/10495/11633 |
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spa |
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spa |
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Iatreia |
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Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
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info:eu-repo/semantics/openAccess |
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Universidad de Antioquia, Facultad de Medicina |
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Inmunovirología |
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Medellín, Colombia |
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Universidad de Antioquia |
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Gómez Gallego, Diana MaryoryUrcuqui Inchima, SilvioHernández López, Juan Carlos2019-08-10T14:19:43Z2019-08-10T14:19:43Z2016Gómez-Gallego DM, Urcuqui-Inchima S, Hernández JC. Efecto inmunomodulador de nanopartículas usadas en nanomedicina. Iatreia. 2016 Oct-Dic;29(4):445-457. DOI 10.17533/udea.iatreia.v29n4a060121-0793http://hdl.handle.net/10495/1163310.17533/udea.iatreia.v29n4a062011-7965ABSTRACT: Nanoparticles (NP) are structures with a size on the nanometer scale (1 x 10-9 m). Due to their characteristics, their potential use in the fields of biotechnology and biomedicine has grown in recent years with a wide range of applications, such as diagnosis, therapy and regenerative medicine. The immune system is responsible for defending the body against pathogenic organisms and other foreign agents, such as NP, which can be recognized by such system, interact with it and modulate its function inducing immunostimulatory or immunosuppressive effects. The latter could be used as anti-inflammatory therapeutic agents or to treat autoimmune diseases, and those that activate the immune system, as adjuvants in vaccination or enhancers of the immune response in cancer and other human diseases. However, their use in nanomedicine should be submitted to preliminary tests to determine their effects on the immune response before being applied to biological systems. For this reason it is important to know their composition, size and surface characteristics, as well as other physicochemical properties, directly involved in the effects on the immune system. We present an overview about the relationship between the physicochemical characteristics of NP candidates to be used in the biomedical and biotechnological fields and their immunomodulatory activity. Key words: Immunomodulation; Nanomedicine; Nanoparticles.RESUMEN: Las nanopartículas (NP) son estructuras con tamaño en la escala nanométrica (1 x 10-9 m). Por sus características, en los últimos años ha crecido su potencial para usarlas en los campos biotecnológico y biomédico en una amplia gama de aplicaciones, tales como el diagnóstico, la terapia y la medicina regenerativa. El sistema inmunológico es el responsable de la defensa del cuerpo ante organismos patógenos y otros agentes extraños, como las NP, que pueden ser reconocidas por dicho sistema, interactuar con él y modular su función induciendo efectos inmunosupresores o inmunoestimuladores. Las primeras se podrían utilizar como agentes terapéuticos antinflamatorios o para tratar las enfermedades autoinmunes, y las que activan el sistema inmune, como adyuvantes en vacunación o potenciadores de la respuesta inmune en cáncer y otras enfermedades humanas. Sin embargo, su uso en nanomedicina debe estar sujeto a ensayos previos que determinen su efecto en la respuesta inmune antes de aplicarlas a los sistemas biológicos. Por esta razón es importante conocer su composición, tamaño y características superficiales, entre otras propiedades fisicoquímicas, directamente implicadas en los efectos sobre el sistema inmune. Se presenta una visión general de la relación entre las propiedades fisicoquímicas de las NP candidatas para ser usadas en los campos biomédico y biotecnológico y su actividad inmunomoduladora.12application/pdfspaUniversidad de Antioquia, Facultad de MedicinaInmunovirologíaMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/InmunomodulaciónNanomedicinaNanopartículasTerapia InmunomoduladoraNanoteranósticaSistema inmunológicoEfecto inmunomodulador de nanopartículas usadas en nanomedicinaIatreiaIatreia445457294ORIGINALEfectoinmunomoduladornanopartículas_2016_DianaMaryoryGómezGallego.pdfEfectoinmunomoduladornanopartículas_2016_DianaMaryoryGómezGallego.pdfapplication/pdf870720http://bibliotecadigital.udea.edu.co/bitstream/10495/11633/1/Efectoinmunomoduladornanopart%c3%adculas_2016_DianaMaryoryG%c3%b3mezGallego.pdf0d0125807a6f96feb64a12490b103447MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/11633/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/11633/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/11633/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/11633/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/11633oai:bibliotecadigital.udea.edu.co:10495/116332021-04-01 13:30:00.554Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |