Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B
ABSTRACT: Renealmia alpinia (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of R. alpinia leaves showed potent inhibition of human mon...
- Autores:
-
Benjumea Gutiérrez, Dora María
Gómez Betancur, Isabel Cristina
León, Francisco
Tekwani, Babu L.
Walker, Larry A.
Chaurasiya, Narayan D.
Cutler, Stephen J.
Ding, Yuanquing
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/20247
- Acceso en línea:
- http://hdl.handle.net/10495/20247
- Palabra clave:
- Monoaminooxidasa
Monoamine Oxidase
Zingiberaceae
Extractos de hoja
Leaf extracts
Renealmia alpinia
http://aims.fao.org/aos/agrovoc/c_8522
http://aims.fao.org/aos/agrovoc/c_35308
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/
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| dc.title.spa.fl_str_mv |
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B |
| title |
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B |
| spellingShingle |
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B Monoaminooxidasa Monoamine Oxidase Zingiberaceae Extractos de hoja Leaf extracts Renealmia alpinia http://aims.fao.org/aos/agrovoc/c_8522 http://aims.fao.org/aos/agrovoc/c_35308 |
| title_short |
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B |
| title_full |
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B |
| title_fullStr |
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B |
| title_full_unstemmed |
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B |
| title_sort |
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B |
| dc.creator.fl_str_mv |
Benjumea Gutiérrez, Dora María Gómez Betancur, Isabel Cristina León, Francisco Tekwani, Babu L. Walker, Larry A. Chaurasiya, Narayan D. Cutler, Stephen J. Ding, Yuanquing |
| dc.contributor.author.none.fl_str_mv |
Benjumea Gutiérrez, Dora María Gómez Betancur, Isabel Cristina León, Francisco Tekwani, Babu L. Walker, Larry A. Chaurasiya, Narayan D. Cutler, Stephen J. Ding, Yuanquing |
| dc.contributor.researchgroup.spa.fl_str_mv |
Toxinología Alternativas Terapéuticas y Alimentarias |
| dc.subject.decs.none.fl_str_mv |
Monoaminooxidasa Monoamine Oxidase |
| topic |
Monoaminooxidasa Monoamine Oxidase Zingiberaceae Extractos de hoja Leaf extracts Renealmia alpinia http://aims.fao.org/aos/agrovoc/c_8522 http://aims.fao.org/aos/agrovoc/c_35308 |
| dc.subject.agrovoc.none.fl_str_mv |
Zingiberaceae Extractos de hoja Leaf extracts |
| dc.subject.proposal.spa.fl_str_mv |
Renealmia alpinia |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_8522 http://aims.fao.org/aos/agrovoc/c_35308 |
| description |
ABSTRACT: Renealmia alpinia (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of R. alpinia leaves showed potent inhibition of human monoamine oxidases- (MAOs-) A and B. Phytochemical studies yielded six known compounds, including pinostrobin 1, 4′-methyl ether sakuranetin 2, sakuranetin 3, pinostrobin chalcone 4, yashabushidiol A 5, and desmethoxyyangonin 6. Compound 6 displayed about 30-fold higher affinity for MAO-B than MAO-A, with Ki values of 31 and 922 nM, respectively. Kinetic analysis of inhibition and equilibrium-dialysis dissociation assay of the enzyme-inhibitor complex showed reversible binding of desmethoxyyangonin 6 with MAO-A and MAO-B. The binding interactions of compound 6 in the active site of the MAO-A and MAO-B isoenzymes, investigated through molecular modeling algorithms, confirmed preferential binding of desmethoxyyangonin 6 with MAO-B compared to MAO-A. Selective reversible inhibitors of MAO-B, like desmethoxyyangonin 6, may have important therapeutic significance for the treatment of neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease. |
| publishDate |
2017 |
| dc.date.issued.none.fl_str_mv |
2017 |
| dc.date.accessioned.none.fl_str_mv |
2021-06-22T22:03:11Z |
| dc.date.available.none.fl_str_mv |
2021-06-22T22:03:11Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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1741-427X |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/20247 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2017/4018724 |
| dc.identifier.eissn.none.fl_str_mv |
1741-4288 |
| identifier_str_mv |
1741-427X 10.1155/2017/4018724 1741-4288 |
| url |
http://hdl.handle.net/10495/20247 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Evid. based complement. altern. med. |
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10 |
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1 |
| dc.relation.citationvolume.spa.fl_str_mv |
2017 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Evidence-Based Complementary and Alternative Medicine |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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Oxford, Reino Unido |
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Universidad de Antioquia |
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Benjumea Gutiérrez, Dora MaríaGómez Betancur, Isabel CristinaLeón, FranciscoTekwani, Babu L.Walker, Larry A.Chaurasiya, Narayan D.Cutler, Stephen J.Ding, YuanquingToxinología Alternativas Terapéuticas y Alimentarias2021-06-22T22:03:11Z2021-06-22T22:03:11Z20171741-427Xhttp://hdl.handle.net/10495/2024710.1155/2017/40187241741-4288ABSTRACT: Renealmia alpinia (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of R. alpinia leaves showed potent inhibition of human monoamine oxidases- (MAOs-) A and B. Phytochemical studies yielded six known compounds, including pinostrobin 1, 4′-methyl ether sakuranetin 2, sakuranetin 3, pinostrobin chalcone 4, yashabushidiol A 5, and desmethoxyyangonin 6. Compound 6 displayed about 30-fold higher affinity for MAO-B than MAO-A, with Ki values of 31 and 922 nM, respectively. Kinetic analysis of inhibition and equilibrium-dialysis dissociation assay of the enzyme-inhibitor complex showed reversible binding of desmethoxyyangonin 6 with MAO-A and MAO-B. The binding interactions of compound 6 in the active site of the MAO-A and MAO-B isoenzymes, investigated through molecular modeling algorithms, confirmed preferential binding of desmethoxyyangonin 6 with MAO-B compared to MAO-A. Selective reversible inhibitors of MAO-B, like desmethoxyyangonin 6, may have important therapeutic significance for the treatment of neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease.COL001447610application/pdfengHindawiOxford, Reino Unidohttps://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-BArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionMonoaminooxidasaMonoamine OxidaseZingiberaceaeExtractos de hojaLeaf extractsRenealmia alpiniahttp://aims.fao.org/aos/agrovoc/c_8522http://aims.fao.org/aos/agrovoc/c_35308Evid. based complement. altern. med.1012017Evidence-Based Complementary and Alternative MedicinePublicationORIGINALBenjumeaDora_2017_InteractionsDesmethoxyyangoninMetabolite.pdfBenjumeaDora_2017_InteractionsDesmethoxyyangoninMetabolite.pdfArtículo de investigaciónapplication/pdf3324081https://bibliotecadigital.udea.edu.co/bitstreams/783f385d-1c1b-454c-959d-7e9575f55e71/download3ff41c5f5d408649faa1fbc4d321772fMD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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