Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers
ABSTRACT: This manuscript is an inedited part of my PhD dissertation, based on historical and recent findings on animal models, that was presented as part of the requirements to fulfill the conditions to become a philosophical doctor on Veterinary Sciences at the University of Wisconsin on October o...
- Autores:
-
Rodas González, Juan David
Hewson, Roger
Salvato, María
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2009
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/8349
- Acceso en línea:
- http://hdl.handle.net/10495/8349
- Palabra clave:
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
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Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers |
| dc.title.alternative.spa.fl_str_mv |
Contribución de los modelos murino y primate al estudio de las enfermedades por arenavirus y fiebres hemorrágicas |
| title |
Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers |
| spellingShingle |
Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers |
| title_short |
Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers |
| title_full |
Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers |
| title_fullStr |
Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers |
| title_full_unstemmed |
Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers |
| title_sort |
Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers |
| dc.creator.fl_str_mv |
Rodas González, Juan David Hewson, Roger Salvato, María |
| dc.contributor.author.none.fl_str_mv |
Rodas González, Juan David Hewson, Roger Salvato, María |
| description |
ABSTRACT: This manuscript is an inedited part of my PhD dissertation, based on historical and recent findings on animal models, that was presented as part of the requirements to fulfill the conditions to become a philosophical doctor on Veterinary Sciences at the University of Wisconsin on October of 2003.The current mini-review written on a free-version style, underlines some of the cornerstones of immunology as a science, understood thanks to the use of the Lymphocytic Choriomeningitis virus (LCMV) experimentally and naturally infected mouse model. It should suffice to say that there have been two Nobel prices of Medicine for discoveries made through the employment of this animal model, in order to recognize the right importance to it. In addition, several laboratories, Dr. Salvato´s among them, have also employed the LCMV-infected Rhesus monkey model as a tool to unravel the mysteries of arenaviral hemorrhagic fever, and particularly the physiopathology of Lassa disease in humans. Here I show some of the knowledge generated through the study of both animal infections. |
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2009 |
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2009 |
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2017-09-26T22:09:47Z |
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2017-09-26T22:09:47Z |
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Rodas JD, Hewson R, Salvato M. Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers. Rev. Colomb. Cienc. Pecu. 2009;22(3):267-277. |
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0120-0690 |
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http://hdl.handle.net/10495/8349 |
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2256-2958 |
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Rodas JD, Hewson R, Salvato M. Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers. Rev. Colomb. Cienc. Pecu. 2009;22(3):267-277. 0120-0690 2256-2958 |
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eng |
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eng |
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Rev. Colomb. Cienc. Pecu. |
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Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
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Universidad de Antioquia, Facultad de Ciencias Agrarias |
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CENTAURO |
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Medellín, Colombia |
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Rodas González, Juan DavidHewson, RogerSalvato, María2017-09-26T22:09:47Z2017-09-26T22:09:47Z2009Rodas JD, Hewson R, Salvato M. Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic fevers. Rev. Colomb. Cienc. Pecu. 2009;22(3):267-277.0120-0690http://hdl.handle.net/10495/83492256-2958ABSTRACT: This manuscript is an inedited part of my PhD dissertation, based on historical and recent findings on animal models, that was presented as part of the requirements to fulfill the conditions to become a philosophical doctor on Veterinary Sciences at the University of Wisconsin on October of 2003.The current mini-review written on a free-version style, underlines some of the cornerstones of immunology as a science, understood thanks to the use of the Lymphocytic Choriomeningitis virus (LCMV) experimentally and naturally infected mouse model. It should suffice to say that there have been two Nobel prices of Medicine for discoveries made through the employment of this animal model, in order to recognize the right importance to it. In addition, several laboratories, Dr. Salvato´s among them, have also employed the LCMV-infected Rhesus monkey model as a tool to unravel the mysteries of arenaviral hemorrhagic fever, and particularly the physiopathology of Lassa disease in humans. Here I show some of the knowledge generated through the study of both animal infections.RESUMEN: El siguiente manuscrito, es un capítulo inédito de mi tesis doctoral, basado en hallazgos históricos y recientes sobre modelos animales, que fue presentado como parte de los requisitos para obtener el título de Ph.D. en Ciencias veterinarias en la Universidad de Wisconsin, en Octubre de 2003.La actual minirevisión escrita en estilo de versión libre, subraya algunas de las piedras angulares de la inmunología como ciencia, entendidas gracias al uso del modelo murino infectado natural y experimentalmente con el virus de Coriomeningitis Linfocítica (LCMV). Sería suficiente mencionar que han existido dos premios Nóbel de Medicina por descubrimientos realizados a través del empleo de este modelo animal, para reconocer la real importancia del mismo. Adicionalmente, varios laboratorios, el de la Dra. Salvato entre ellos, también han empleado el modelo del mono Rhesus como un instrumento para desvelar los misterios de las fiebres hemorrágicas por arenavirus, y particularmente la fisiopatología de la enfermedad de Lassa en humanos. Aquí yo muestro algo del conocimiento generado a través del estudio de ambas infecciones animales.COL0001262application/pdfengUniversidad de Antioquia, Facultad de Ciencias AgrariasCENTAUROMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVArtículo de revisiónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic feversContribución de los modelos murino y primate al estudio de las enfermedades por arenavirus y fiebres hemorrágicasRev. Colomb. Cienc. Pecu.Revista Colombiana de Ciencias Pecuarias267277223ORIGINALRodasJuanD_2009_ContributionMurinePrimateArenaviral.pdfRodasJuanD_2009_ContributionMurinePrimateArenaviral.pdfArtículo de revisiónapplication/pdf140847https://bibliotecadigital.udea.edu.co/bitstream/10495/8349/1/RodasJuanD_2009_ContributionMurinePrimateArenaviral.pdf494a88b1bfeb2ff323edc2fbc24c01a9MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849https://bibliotecadigital.udea.edu.co/bitstream/10495/8349/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80https://bibliotecadigital.udea.edu.co/bitstream/10495/8349/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80https://bibliotecadigital.udea.edu.co/bitstream/10495/8349/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/8349/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/8349oai:bibliotecadigital.udea.edu.co:10495/83492021-05-21 20:32:24.911Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |