Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria
ABSTRACT: We are not aware of studies in Colombia on levels of specific IgE in children without malaria and only one is available in children with uncomplicated malaria. Objective: To measure anti-Plasmodium IgE in children with or without malaria according to sex, nutritional status, and the presen...
- Autores:
-
Carmona Fonseca, Jaime
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2013
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12627
- Acceso en línea:
- http://hdl.handle.net/10495/12627
- Palabra clave:
- Colombia
Desnutrición
Inmunoglobulina E
Malaria
Plasmodium
Sexo
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0/
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Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria |
| dc.title.translated.spa.fl_str_mv |
Anti-Plasmodium immunoglobulin E in children of Urabá (Colombia) according to the presence of malaria |
| title |
Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria |
| spellingShingle |
Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria Colombia Desnutrición Inmunoglobulina E Malaria Plasmodium Sexo |
| title_short |
Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria |
| title_full |
Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria |
| title_fullStr |
Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria |
| title_full_unstemmed |
Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria |
| title_sort |
Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria |
| dc.creator.fl_str_mv |
Carmona Fonseca, Jaime |
| dc.contributor.author.none.fl_str_mv |
Carmona Fonseca, Jaime |
| dc.contributor.researchgroup.spa.fl_str_mv |
Salud y Comunidad |
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Colombia Desnutrición Inmunoglobulina E Malaria Plasmodium Sexo |
| topic |
Colombia Desnutrición Inmunoglobulina E Malaria Plasmodium Sexo |
| description |
ABSTRACT: We are not aware of studies in Colombia on levels of specific IgE in children without malaria and only one is available in children with uncomplicated malaria. Objective: To measure anti-Plasmodium IgE in children with or without malaria according to sex, nutritional status, and the presence of intestinal helminthes, and the relations with hematologic variables. Methodology: anti-Plasmodium IgE was measured in 335 children without malaria and in 125 with uncomplicated malaria (P. vivax: 116; P. falciparum: 9). Measurement was done with the ELISA technique, with a crude antigen extract of P. falciparum FCB-2 strain. We used Sigma`s conjugated anti-anti-IgE A3525. IgE was measured and expressed as optical density (absorbance). Results: Anti-Plasmodium IgE in children without malaria was 0.808 ± 0.508 (cutoff point used to define high level: 0.584) and 1.968 ± 1.237 in children with malaria (p = 0.000000). Anti-Plasmodium IgE levels showed no significant difference according to plasmodial species but there was significant difference by sex and nutritional status. In children without malaria, the level of anti-Plasmodium IgE was higher in those with the presence of roundworm, whipworm and hookworm, but the difference was significant only for roundworms. The level of anti-Plasmodium IgE showed significant positive linear correlation with the number of eggs of Ascaris and whipworm per gram of stool. Conclusions: In Urabá, children with or without malaria have elevated levels of anti-Plasmodium IgE, that are higher in women and in those affected by malaria. |
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2013 |
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2013 |
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2019-12-19T12:07:06Z |
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2019-12-19T12:07:06Z |
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Artículo de investigación |
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Carmona Fonseca J. Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria. Iatreia. 2013 Oct-Dic; 26(4): 408-418. |
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0121-0793 |
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http://hdl.handle.net/10495/12627 |
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2011-7965 |
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Carmona Fonseca J. Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria. Iatreia. 2013 Oct-Dic; 26(4): 408-418. 0121-0793 2011-7965 |
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Iatreia |
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408 |
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26 |
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Iatreia |
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Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
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Universidad de Antioquia, Facultad de Medicina |
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Medellín, Colombia |
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Universidad de Antioquia |
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Carmona Fonseca, JaimeSalud y Comunidad2019-12-19T12:07:06Z2019-12-19T12:07:06Z2013Carmona Fonseca J. Inmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malaria. Iatreia. 2013 Oct-Dic; 26(4): 408-418.0121-0793http://hdl.handle.net/10495/126272011-7965ABSTRACT: We are not aware of studies in Colombia on levels of specific IgE in children without malaria and only one is available in children with uncomplicated malaria. Objective: To measure anti-Plasmodium IgE in children with or without malaria according to sex, nutritional status, and the presence of intestinal helminthes, and the relations with hematologic variables. Methodology: anti-Plasmodium IgE was measured in 335 children without malaria and in 125 with uncomplicated malaria (P. vivax: 116; P. falciparum: 9). Measurement was done with the ELISA technique, with a crude antigen extract of P. falciparum FCB-2 strain. We used Sigma`s conjugated anti-anti-IgE A3525. IgE was measured and expressed as optical density (absorbance). Results: Anti-Plasmodium IgE in children without malaria was 0.808 ± 0.508 (cutoff point used to define high level: 0.584) and 1.968 ± 1.237 in children with malaria (p = 0.000000). Anti-Plasmodium IgE levels showed no significant difference according to plasmodial species but there was significant difference by sex and nutritional status. In children without malaria, the level of anti-Plasmodium IgE was higher in those with the presence of roundworm, whipworm and hookworm, but the difference was significant only for roundworms. The level of anti-Plasmodium IgE showed significant positive linear correlation with the number of eggs of Ascaris and whipworm per gram of stool. Conclusions: In Urabá, children with or without malaria have elevated levels of anti-Plasmodium IgE, that are higher in women and in those affected by malaria.RESUMEN: No existen informes en Colombia sobre los niveles de IgE anti-Plasmodium en niños sin malaria y apenas hay uno en niños con malaria no complicada. Objetivo: medir la IgE anti-Plasmodium en niños sin malaria o con ella en función del sexo, el estado nutricional y la presencia de helmintos intestinales, y las relaciones con variables hematológicas. Metodología: la IgE anti-Plasmodium se midió en 335 niños sin malaria y en 125 con malaria no complicada (116 P. vivax, 9 P. falciparum). La medición se hizo con la técnica de ELISA, con antígeno de extracto crudo de P. falciparum, cepa FCB-2. Se usó el conjugado anti-anti-IgE de Sigma A3525. La IgE se midió y expresó según la densidad óptica (absorbancia). Resultados: la IgE anti-Plasmodium fue de 0,808 ± 0,508 en niños sin malaria (punto de corte usado para definir nivel alto: 0,584) y 1,968 ± 1,237 en niños con malaria (p = 0,000000). La IgE anti-Plasmodium no mostró diferencia significativa según la especie plasmodial, pero sí según el sexo y el estado nutricional de los niños. En niños sin malaria, el nivel de IgE anti-Plasmodium fue mayor en aquellos con presencia de áscaris, tricocéfalos y uncinarias, pero la diferencia fue significativa únicamente para áscaris. El nivel de IgE anti-Plasmodium mostró correlación lineal positiva y significativa con la cantidad de huevos de tricocéfalo y de áscaris por gramo de materia fecal. Conclusiones: los niños sin malaria o con ella de Urabá tienen elevados niveles de IgE anti-Plasmodium, que son más altos en mujeres y en los afectados por paludismo.10application/pdfspaUniversidad de Antioquia, Facultad de MedicinaMedellín, Colombiahttps://creativecommons.org/licenses/by-nc-sa/4.0/https://creativecommons.org/licenses/by-nc-sa/2.5/co/Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2ColombiaDesnutriciónInmunoglobulina EMalariaPlasmodiumSexoInmunoglobulina E anti-Plasmodium en niños de Urabá (Colombia) según la presencia de malariaAnti-Plasmodium immunoglobulin E in children of Urabá (Colombia) according to the presence of malariaArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionIatreia418440826IatreiaPublicationORIGINALCarmonaFonsecaJaime_2013_InmunoglobulinaEAntiPlasmodium.pdfCarmonaFonsecaJaime_2013_InmunoglobulinaEAntiPlasmodium.pdfArtículo de investigaciónapplication/pdf630558https://bibliotecadigital.udea.edu.co/bitstreams/a5a631c4-e568-4685-a673-a268e423f613/download321e670a3526048b00b77cc557e2614aMD51trueAnonymousREADCC-LICENSElicense_urllicense_urltext/plain; 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