Interleucina-6 : ¿amiga o enemiga? Bases para comprender su utilidad como objetivo terapéutico
ABSTRACT: Cytokines are intercellular communication molecules. They exhibit a great range of actions in different systems and organic processes, notably in the mechanisms that produce the inflammatory response. Interleukin-6 is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory...
- Autores:
-
Saavedra Ramírez, Publio Giovanni
Vásquez Duque, Gloria María
González Naranjo, Luis Alonso
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12874
- Acceso en línea:
- http://hdl.handle.net/10495/12874
- Palabra clave:
- Artritis Reumatoide
Autoinmunidad
Inflamación
Interleucina-6
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
| Summary: | ABSTRACT: Cytokines are intercellular communication molecules. They exhibit a great range of actions in different systems and organic processes, notably in the mechanisms that produce the inflammatory response. Interleukin-6 is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory functions. Evidence links this cytokine in an important and direct way with the pathophysiology of diverse autoimmune diseases, in particular, rheumatoid arthritis. This is a review of the molecular basis and the biological effects of interleukin-6. The clinical experience accumulated with therapies that block its pro-inflammatory actions in patients with rheumatoid arthritis are also included. |
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