Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
ABSTARCT: The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulf...
- Autores:
-
Galvis Ramírez, Manuel Fernando
Quintana Castillo, Juan Carlos
Bueno Sanchez, Julio Cesar
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12981
- Acceso en línea:
- http://hdl.handle.net/10495/12981
- Palabra clave:
- Glomerular Endothelia Dysfunction
Preeclampsia
Heparan Sulfate (HS)
Systemic Inflammatory Response
Renal Damage
- Rights
- openAccess
- License
- Atribución 2.5
| id |
UDEA2_8d241793b64a6d81aae2a8a686640216 |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/12981 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| spellingShingle |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia Glomerular Endothelia Dysfunction Preeclampsia Heparan Sulfate (HS) Systemic Inflammatory Response Renal Damage |
| title_short |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title_full |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title_fullStr |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title_full_unstemmed |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title_sort |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| dc.creator.fl_str_mv |
Galvis Ramírez, Manuel Fernando Quintana Castillo, Juan Carlos Bueno Sanchez, Julio Cesar |
| dc.contributor.author.none.fl_str_mv |
Galvis Ramírez, Manuel Fernando Quintana Castillo, Juan Carlos Bueno Sanchez, Julio Cesar |
| dc.subject.none.fl_str_mv |
Glomerular Endothelia Dysfunction Preeclampsia Heparan Sulfate (HS) Systemic Inflammatory Response Renal Damage |
| topic |
Glomerular Endothelia Dysfunction Preeclampsia Heparan Sulfate (HS) Systemic Inflammatory Response Renal Damage |
| description |
ABSTARCT: The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia. |
| publishDate |
2018 |
| dc.date.issued.none.fl_str_mv |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2020-01-10T17:27:55Z |
| dc.date.available.none.fl_str_mv |
2020-01-10T17:27:55Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_dcae04bc |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ARTREV |
| dc.type.local.spa.fl_str_mv |
Artículo de revisión |
| format |
http://purl.org/coar/resource_type/c_dcae04bc |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sánchez JC. Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 2018;9:1470. doi: 10.3389/fphys.2018.01470 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/12981 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fphys.2018.01470 |
| dc.identifier.eissn.none.fl_str_mv |
1664-042X |
| identifier_str_mv |
Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sánchez JC. Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 2018;9:1470. doi: 10.3389/fphys.2018.01470 10.3389/fphys.2018.01470 1664-042X |
| url |
http://hdl.handle.net/10495/12981 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Front Physiol |
| dc.rights.*.fl_str_mv |
Atribución 2.5 |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ |
| dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| rights_invalid_str_mv |
Atribución 2.5 http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
9 |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Frontiers Research Foundation |
| dc.publisher.group.spa.fl_str_mv |
Grupo Reproducción |
| dc.publisher.place.spa.fl_str_mv |
Suiza |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/3/GalvisManuel_2018_GlycansGlomerularPreeclapsia.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/4/license_url http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/5/license_text http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/6/license_rdf http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/7/license.txt |
| bitstream.checksum.fl_str_mv |
7bf0e27d3e2ff35e3b8b32941a318ef5 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e 8a4605be74aa9ea9d79846c1fba20a33 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
| repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
| _version_ |
1812173152153763840 |
| spelling |
Galvis Ramírez, Manuel FernandoQuintana Castillo, Juan CarlosBueno Sanchez, Julio Cesar2020-01-10T17:27:55Z2020-01-10T17:27:55Z2018Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sánchez JC. Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 2018;9:1470. doi: 10.3389/fphys.2018.01470http://hdl.handle.net/10495/1298110.3389/fphys.2018.014701664-042XABSTARCT: The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia.9application/pdfspaFrontiers Research FoundationGrupo ReproducciónSuizainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVArtículo de revisiónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución 2.5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Glomerular Endothelia DysfunctionPreeclampsiaHeparan Sulfate (HS)Systemic Inflammatory ResponseRenal DamageNovel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in PreeclampsiaFront PhysiolFrontiers in Physiology11091470ORIGINALGalvisManuel_2018_GlycansGlomerularPreeclapsia.pdfGalvisManuel_2018_GlycansGlomerularPreeclapsia.pdfArtículo de revisiónapplication/pdf1144101http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/3/GalvisManuel_2018_GlycansGlomerularPreeclapsia.pdf7bf0e27d3e2ff35e3b8b32941a318ef5MD53CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/4/license_url4afdbb8c545fd630ea7db775da747b2fMD54license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/5/license_textd41d8cd98f00b204e9800998ecf8427eMD55license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/6/license_rdfd41d8cd98f00b204e9800998ecf8427eMD56LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/12981/7/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5710495/12981oai:bibliotecadigital.udea.edu.co:10495/129812021-04-03 17:01:46.951Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |