Evolutionary structure of Plasmodium falciparum major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance
ABSTARCT: Strong founder effects resulting from human migration out of Africa have led to geographic variation in single nucleotide polymorphisms (SNPs) and microsatellites (MS) of the malaria parasite, Plasmodium falciparum. This is particularly striking in South America where two major founder pop...
- Autores:
-
Rougeron, Virginie
Tiedje, Kathryn E
Chen, Donald S
Maestre Buitrago, Amanda Elena
Gamboa, Dionicia
Musset, Lise
Legrand, Eric
Noya, Oscar
Yalcindag, Erhan
Renaud, François
Prugnolle, Franck
Day, Karen P
Rask, Thomas S
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11433
- Acceso en línea:
- http://hdl.handle.net/10495/11433
- Palabra clave:
- Evolutionary structure
Plasmodium falciparum
Plasmodium falciparum Erythrocyte Membrane Protein 1
Population genomics
Var genes
Malaria
- Rights
- openAccess
- License
- Atribución 2.5
| Summary: | ABSTARCT: Strong founder effects resulting from human migration out of Africa have led to geographic variation in single nucleotide polymorphisms (SNPs) and microsatellites (MS) of the malaria parasite, Plasmodium falciparum. This is particularly striking in South America where two major founder populations of P. falciparum have been identified that are presumed to have arisen from the transatlantic slave trade. Given the importance of the major variant surface antigen of the blood stages of P. falciparum as both a virulence factor and target of immunity, we decided to investigate the population genetics of the genes encoding "Plasmodium falciparum Erythrocyte Membrane Protein 1" (Pf EMP1) among several countries in South America, in order to evaluate the transmission patterns of malaria in this continent. Deep sequencing of the DBLα domain of var genes from 128 P. falciparum isolates from five locations in South America was completed using a 454 high throughput sequencing protocol. Striking geographic variation in var DBLα sequences, similar to that seen for SNPs and MS markers, was observed. Colombia and French Guiana had distinct var DBLα sequences, whereas Peru and Venezuela showed an admixture. The importance of such geographic variation to herd immunity and malaria vaccination is discussed. |
|---|