Subtypes of Native American ancestry and leading causes of death: Mapuche ancestryspecific associations with gallbladder cancer risk in Chile

ABSTRACT: Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between...

Full description

Autores:
Bermejo, Justo Lorenzo
Boekstegers, Felix
González Silos, Rosa
Marcelain, Katherine
Baez Benavides, Pablo
Barahona Ponce, Carol
Müller, Bettina
Ferreccio, Catterina
Koshiol, Jill
Fischer, Christine
Peil, Barbara
Sinsheimer, Janet
Fuentes Guajardo, Macarena
Barajas, Olga
González José, Rolando
Bedoya Berrío, Gabriel de Jesús
Bortolini, Maria Cátira
Canizales Quinteros, Samuel
Gallo, Carla
Ruíz Linares, Andres
Rothhammer, Francisco
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/23698
Acceso en línea:
http://hdl.handle.net/10495/23698
Palabra clave:
Neoplasias de la Vesícula Biliar
Gallbladder Neoplasms
Genética de Población
Genetics, Population
Mapuches
Mapuche Indians
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
Description
Summary:ABSTRACT: Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls. Native American proportions were markedly underestimated when the two main types of Native American ancestry in Chile, originated from the Mapuche and Aymara indigenous peoples, were combined together. Consideration of the type of Native American ancestry was crucial to identify disease associations. Native American ancestry showed no association with gallbladder cancer mortality (P = 0.26). By contrast, each 1% increase in the Mapuche proportion represented a 3.7% increased mortality risk by gallbladder cancer (95%CI 3.1–4.3%, P = 6×10−27). Individual-data results and extensive sensitivity analyses confirmed the association between Mapuche ancestry and gallbladder cancer. Increasing Mapuche proportions were also associated with an increased mortality due to asthma and, interestingly, with a decreased mortality by diabetes. The mortality due to skin, bladder, larynx, bronchus and lung cancers increased with increasing Aymara proportions. Described methods should be considered in future studies on human population genetics and human health. Complementary individual-based studies are needed to apportion the g.