Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group

ABSTRACT: The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale co...

Full description

Autores:
López Jaramillo, Carlos Alberto
Vargas Upegui, Cristian David
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/23113
Acceso en línea:
http://hdl.handle.net/10495/23113
Palabra clave:
Sustancia Blanca
White Matter
Esquizofrenia
Schizophrenia
Imagen de Difusión Tensora
Diffusion Tensor Imaging
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/23113
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
title Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
spellingShingle Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
Sustancia Blanca
White Matter
Esquizofrenia
Schizophrenia
Imagen de Difusión Tensora
Diffusion Tensor Imaging
title_short Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
title_full Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
title_fullStr Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
title_full_unstemmed Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
title_sort Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
dc.creator.fl_str_mv López Jaramillo, Carlos Alberto
Vargas Upegui, Cristian David
dc.contributor.author.none.fl_str_mv López Jaramillo, Carlos Alberto
Vargas Upegui, Cristian David
dc.subject.decs.none.fl_str_mv Sustancia Blanca
White Matter
Esquizofrenia
Schizophrenia
Imagen de Difusión Tensora
Diffusion Tensor Imaging
topic Sustancia Blanca
White Matter
Esquizofrenia
Schizophrenia
Imagen de Difusión Tensora
Diffusion Tensor Imaging
description ABSTRACT: The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2021-10-11T16:29:33Z
dc.date.available.none.fl_str_mv 2021-10-11T16:29:33Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.local.spa.fl_str_mv Artículo de investigación
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dc.identifier.citation.spa.fl_str_mv Kelly, S., Jahanshad, N., Zalesky, A. et al. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Mol Psychiatry 23, 1261–1269 (2018). https://doi.org/10.1038/mp.2017.170
dc.identifier.issn.none.fl_str_mv 1359-4184
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/23113
dc.identifier.doi.none.fl_str_mv 10.1038/mp.2017.170
dc.identifier.eissn.none.fl_str_mv 1476-5578
identifier_str_mv Kelly, S., Jahanshad, N., Zalesky, A. et al. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Mol Psychiatry 23, 1261–1269 (2018). https://doi.org/10.1038/mp.2017.170
1359-4184
10.1038/mp.2017.170
1476-5578
url http://hdl.handle.net/10495/23113
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Mol. Psychiatry.
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eu_rights_str_mv openAccess
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dc.publisher.spa.fl_str_mv Springer Nature
dc.publisher.group.spa.fl_str_mv Grupo de Investigación en Psiquiatría GIPSI
dc.publisher.place.spa.fl_str_mv Londres, Inglaterra
institution Universidad de Antioquia
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spelling López Jaramillo, Carlos AlbertoVargas Upegui, Cristian David2021-10-11T16:29:33Z2021-10-11T16:29:33Z2017Kelly, S., Jahanshad, N., Zalesky, A. et al. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Mol Psychiatry 23, 1261–1269 (2018). https://doi.org/10.1038/mp.2017.1701359-4184http://hdl.handle.net/10495/2311310.1038/mp.2017.1701476-5578ABSTRACT: The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.COL00291479application/pdfengSpringer NatureGrupo de Investigación en Psiquiatría GIPSILondres, Inglaterrainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working GroupSustancia BlancaWhite MatterEsquizofreniaSchizophreniaImagen de Difusión TensoraDiffusion Tensor ImagingMol. Psychiatry.Molecular Psychiatry1923CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051http://bibliotecadigital.udea.edu.co/bitstream/10495/23113/2/license_rdfe2060682c9c70d4d30c83c51448f4eedMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/23113/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53ORIGINALLopezCarlos_2017_WidespreadSchizophreniaMicrostructural.pdfLopezCarlos_2017_WidespreadSchizophreniaMicrostructural.pdfArtículo de investigaciónapplication/pdf1158906http://bibliotecadigital.udea.edu.co/bitstream/10495/23113/1/LopezCarlos_2017_WidespreadSchizophreniaMicrostructural.pdf5a1f5d5b2f2e9bf60b16d8e9b2a5fc15MD5110495/23113oai:bibliotecadigital.udea.edu.co:10495/231132021-10-11 11:29:33.9Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=