Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
ABSTRACT: Objective: Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD-I) suggest that lithium is associated with increased volumes of cortico-limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of...
- Autores:
-
López Jaramillo, Carlos Alberto
Vargas Upegui, Cristian David
Díaz Zuluaga, Ana María
Palacio Ortiz, Juan David
Castrillón, Gabriel
Bearden, Carrie
Vieta, Eduard
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/29714
- Acceso en línea:
- https://hdl.handle.net/10495/29714
https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467
- Palabra clave:
- Bipolar Disorder
Trastorno Bipolar
Lithium
Litio
Neuroimaging
Neuroimagen
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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oai:bibliotecadigital.udea.edu.co:10495/29714 |
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|
dc.title.spa.fl_str_mv |
Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects |
title |
Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects |
spellingShingle |
Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects Bipolar Disorder Trastorno Bipolar Lithium Litio Neuroimaging Neuroimagen |
title_short |
Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects |
title_full |
Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects |
title_fullStr |
Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects |
title_full_unstemmed |
Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects |
title_sort |
Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects |
dc.creator.fl_str_mv |
López Jaramillo, Carlos Alberto Vargas Upegui, Cristian David Díaz Zuluaga, Ana María Palacio Ortiz, Juan David Castrillón, Gabriel Bearden, Carrie Vieta, Eduard |
dc.contributor.author.none.fl_str_mv |
López Jaramillo, Carlos Alberto Vargas Upegui, Cristian David Díaz Zuluaga, Ana María Palacio Ortiz, Juan David Castrillón, Gabriel Bearden, Carrie Vieta, Eduard |
dc.subject.decs.none.fl_str_mv |
Bipolar Disorder Trastorno Bipolar Lithium Litio Neuroimaging Neuroimagen |
topic |
Bipolar Disorder Trastorno Bipolar Lithium Litio Neuroimaging Neuroimagen |
description |
ABSTRACT: Objective: Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD-I) suggest that lithium is associated with increased volumes of cortico-limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of the present study was to assess differences in brain volumes among long-term lithium-treated BD-I patients, unmedicated BD-I patients, and healthy controls. Methods: This was a cross-sectional study with 32 euthymic BD-I patients (16 on lithium monotherapy for a mean of 180 months, and 16 receiving no medication for at least the 2 months prior to the study) and 20 healthy controls. Patients were euthymic (Hamilton Depression Rating Scale [HDRS] <6 and Young Mania Rating Scale [YMRS] <7) and had not taken psychotropic medications other than lithium for at least 6 months. Brain images were acquired on a 1.5 Tesla MRI (Phillips, Amsterdam, The Netherlands) and segmented to generate volumetric measures of cortical and subcortical brain areas, ventricles and global brain. Results: Significant differences were found in the volumes of the left amygdala (P=.0003), right amygdala (P=.030), left hippocampus (P=.022), left thalamus (P=.022), and right thalamus (P=.019) in long-term lithium-treated BD-I patients, compared to unmedicated patients and controls, after multivariable adjustment. No differences were observed in global brain volume or in ventricular size among the three groups. Likewise, there was no correlation between serum lithium levels and the increase in size in the described brain areas. Conclusions: The structural differences found among the three groups, and specifically those between long-term lithium-treated and unmedicated BD-I patients, indicate increased limbic structure volumes in lithium-treated patients. |
publishDate |
2017 |
dc.date.issued.none.fl_str_mv |
2017 |
dc.date.accessioned.none.fl_str_mv |
2022-07-13T19:20:08Z |
dc.date.available.none.fl_str_mv |
2022-07-13T19:20:08Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
1398-5647 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/29714 |
dc.identifier.doi.none.fl_str_mv |
10.1111/bdi.12467 |
dc.identifier.eissn.none.fl_str_mv |
1399-5618 |
dc.identifier.url.spa.fl_str_mv |
https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467 |
identifier_str_mv |
1398-5647 10.1111/bdi.12467 1399-5618 |
url |
https://hdl.handle.net/10495/29714 https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Bipolar Disord |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.format.extent.spa.fl_str_mv |
9 |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Wiley |
dc.publisher.group.spa.fl_str_mv |
Grupo de Investigación en Psiquiatría GIPSI |
dc.publisher.place.spa.fl_str_mv |
Copenhague, Dinamarca |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/1/LopezCarlos_2017_BipolarDisorderBrainNeuroimaging.pdf https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/2/license_rdf https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/3/license.txt |
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4e77d1565d955e81909f0a63d8417372 b88b088d9957e670ce3b3fbe2eedbc13 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
_version_ |
1812173137748426752 |
spelling |
López Jaramillo, Carlos AlbertoVargas Upegui, Cristian DavidDíaz Zuluaga, Ana MaríaPalacio Ortiz, Juan DavidCastrillón, GabrielBearden, CarrieVieta, Eduard2022-07-13T19:20:08Z2022-07-13T19:20:08Z20171398-5647https://hdl.handle.net/10495/2971410.1111/bdi.124671399-5618https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467ABSTRACT: Objective: Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD-I) suggest that lithium is associated with increased volumes of cortico-limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of the present study was to assess differences in brain volumes among long-term lithium-treated BD-I patients, unmedicated BD-I patients, and healthy controls. Methods: This was a cross-sectional study with 32 euthymic BD-I patients (16 on lithium monotherapy for a mean of 180 months, and 16 receiving no medication for at least the 2 months prior to the study) and 20 healthy controls. Patients were euthymic (Hamilton Depression Rating Scale [HDRS] <6 and Young Mania Rating Scale [YMRS] <7) and had not taken psychotropic medications other than lithium for at least 6 months. Brain images were acquired on a 1.5 Tesla MRI (Phillips, Amsterdam, The Netherlands) and segmented to generate volumetric measures of cortical and subcortical brain areas, ventricles and global brain. Results: Significant differences were found in the volumes of the left amygdala (P=.0003), right amygdala (P=.030), left hippocampus (P=.022), left thalamus (P=.022), and right thalamus (P=.019) in long-term lithium-treated BD-I patients, compared to unmedicated patients and controls, after multivariable adjustment. No differences were observed in global brain volume or in ventricular size among the three groups. Likewise, there was no correlation between serum lithium levels and the increase in size in the described brain areas. Conclusions: The structural differences found among the three groups, and specifically those between long-term lithium-treated and unmedicated BD-I patients, indicate increased limbic structure volumes in lithium-treated patients.00291479application/pdfengWileyGrupo de Investigación en Psiquiatría GIPSICopenhague, Dinamarcainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjectsBipolar DisorderTrastorno BipolarLithiumLitioNeuroimagingNeuroimagenBipolar DisordBipolar Disorders4149191ORIGINALLopezCarlos_2017_BipolarDisorderBrainNeuroimaging.pdfLopezCarlos_2017_BipolarDisorderBrainNeuroimaging.pdfArtículo de investigaciónapplication/pdf385070https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/1/LopezCarlos_2017_BipolarDisorderBrainNeuroimaging.pdf4e77d1565d955e81909f0a63d8417372MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/29714oai:bibliotecadigital.udea.edu.co:10495/297142022-07-13 14:20:08.661Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |