Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects

ABSTRACT: Objective: Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD-I) suggest that lithium is associated with increased volumes of cortico-limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of...

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Autores:
López Jaramillo, Carlos Alberto
Vargas Upegui, Cristian David
Díaz Zuluaga, Ana María
Palacio Ortiz, Juan David
Castrillón, Gabriel
Bearden, Carrie
Vieta, Eduard
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/29714
Acceso en línea:
https://hdl.handle.net/10495/29714
https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467
Palabra clave:
Bipolar Disorder
Trastorno Bipolar
Lithium
Litio
Neuroimaging
Neuroimagen
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_7b702d82098ac061561ec31f42ca1c77
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/29714
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
title Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
spellingShingle Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
Bipolar Disorder
Trastorno Bipolar
Lithium
Litio
Neuroimaging
Neuroimagen
title_short Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
title_full Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
title_fullStr Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
title_full_unstemmed Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
title_sort Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
dc.creator.fl_str_mv López Jaramillo, Carlos Alberto
Vargas Upegui, Cristian David
Díaz Zuluaga, Ana María
Palacio Ortiz, Juan David
Castrillón, Gabriel
Bearden, Carrie
Vieta, Eduard
dc.contributor.author.none.fl_str_mv López Jaramillo, Carlos Alberto
Vargas Upegui, Cristian David
Díaz Zuluaga, Ana María
Palacio Ortiz, Juan David
Castrillón, Gabriel
Bearden, Carrie
Vieta, Eduard
dc.subject.decs.none.fl_str_mv Bipolar Disorder
Trastorno Bipolar
Lithium
Litio
Neuroimaging
Neuroimagen
topic Bipolar Disorder
Trastorno Bipolar
Lithium
Litio
Neuroimaging
Neuroimagen
description ABSTRACT: Objective: Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD-I) suggest that lithium is associated with increased volumes of cortico-limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of the present study was to assess differences in brain volumes among long-term lithium-treated BD-I patients, unmedicated BD-I patients, and healthy controls. Methods: This was a cross-sectional study with 32 euthymic BD-I patients (16 on lithium monotherapy for a mean of 180 months, and 16 receiving no medication for at least the 2 months prior to the study) and 20 healthy controls. Patients were euthymic (Hamilton Depression Rating Scale [HDRS] <6 and Young Mania Rating Scale [YMRS] <7) and had not taken psychotropic medications other than lithium for at least 6 months. Brain images were acquired on a 1.5 Tesla MRI (Phillips, Amsterdam, The Netherlands) and segmented to generate volumetric measures of cortical and subcortical brain areas, ventricles and global brain. Results: Significant differences were found in the volumes of the left amygdala (P=.0003), right amygdala (P=.030), left hippocampus (P=.022), left thalamus (P=.022), and right thalamus (P=.019) in long-term lithium-treated BD-I patients, compared to unmedicated patients and controls, after multivariable adjustment. No differences were observed in global brain volume or in ventricular size among the three groups. Likewise, there was no correlation between serum lithium levels and the increase in size in the described brain areas. Conclusions: The structural differences found among the three groups, and specifically those between long-term lithium-treated and unmedicated BD-I patients, indicate increased limbic structure volumes in lithium-treated patients.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2022-07-13T19:20:08Z
dc.date.available.none.fl_str_mv 2022-07-13T19:20:08Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
dc.type.local.spa.fl_str_mv Artículo de investigación
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 1398-5647
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/29714
dc.identifier.doi.none.fl_str_mv 10.1111/bdi.12467
dc.identifier.eissn.none.fl_str_mv 1399-5618
dc.identifier.url.spa.fl_str_mv https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467
identifier_str_mv 1398-5647
10.1111/bdi.12467
1399-5618
url https://hdl.handle.net/10495/29714
https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Bipolar Disord
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rights.accessrights.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.format.extent.spa.fl_str_mv 9
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Wiley
dc.publisher.group.spa.fl_str_mv Grupo de Investigación en Psiquiatría GIPSI
dc.publisher.place.spa.fl_str_mv Copenhague, Dinamarca
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/1/LopezCarlos_2017_BipolarDisorderBrainNeuroimaging.pdf
https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/2/license_rdf
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repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
repository.mail.fl_str_mv andres.perez@udea.edu.co
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spelling López Jaramillo, Carlos AlbertoVargas Upegui, Cristian DavidDíaz Zuluaga, Ana MaríaPalacio Ortiz, Juan DavidCastrillón, GabrielBearden, CarrieVieta, Eduard2022-07-13T19:20:08Z2022-07-13T19:20:08Z20171398-5647https://hdl.handle.net/10495/2971410.1111/bdi.124671399-5618https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467ABSTRACT: Objective: Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD-I) suggest that lithium is associated with increased volumes of cortico-limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of the present study was to assess differences in brain volumes among long-term lithium-treated BD-I patients, unmedicated BD-I patients, and healthy controls. Methods: This was a cross-sectional study with 32 euthymic BD-I patients (16 on lithium monotherapy for a mean of 180 months, and 16 receiving no medication for at least the 2 months prior to the study) and 20 healthy controls. Patients were euthymic (Hamilton Depression Rating Scale [HDRS] <6 and Young Mania Rating Scale [YMRS] <7) and had not taken psychotropic medications other than lithium for at least 6 months. Brain images were acquired on a 1.5 Tesla MRI (Phillips, Amsterdam, The Netherlands) and segmented to generate volumetric measures of cortical and subcortical brain areas, ventricles and global brain. Results: Significant differences were found in the volumes of the left amygdala (P=.0003), right amygdala (P=.030), left hippocampus (P=.022), left thalamus (P=.022), and right thalamus (P=.019) in long-term lithium-treated BD-I patients, compared to unmedicated patients and controls, after multivariable adjustment. No differences were observed in global brain volume or in ventricular size among the three groups. Likewise, there was no correlation between serum lithium levels and the increase in size in the described brain areas. Conclusions: The structural differences found among the three groups, and specifically those between long-term lithium-treated and unmedicated BD-I patients, indicate increased limbic structure volumes in lithium-treated patients.00291479application/pdfengWileyGrupo de Investigación en Psiquiatría GIPSICopenhague, Dinamarcainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjectsBipolar DisorderTrastorno BipolarLithiumLitioNeuroimagingNeuroimagenBipolar DisordBipolar Disorders4149191ORIGINALLopezCarlos_2017_BipolarDisorderBrainNeuroimaging.pdfLopezCarlos_2017_BipolarDisorderBrainNeuroimaging.pdfArtículo de investigaciónapplication/pdf385070https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/1/LopezCarlos_2017_BipolarDisorderBrainNeuroimaging.pdf4e77d1565d955e81909f0a63d8417372MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/29714/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/29714oai:bibliotecadigital.udea.edu.co:10495/297142022-07-13 14:20:08.661Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=