Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
ABSTARCT: Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2,2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2.3-bis(2-methylbu...
- Autores:
-
Betancur Galvis, Liliana Amparo
Checa, Javier
Marco Ventura, Juan Alberto
Estornell, Ernesto
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2003
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/8522
- Acceso en línea:
- http://hdl.handle.net/10495/8522
- Palabra clave:
- Jatrophane Diterpenes
Látex de euphorbia obtusifolia
Actividad inhibitoria
Cadena respiratoria mitocondrial
- Rights
- openAccess
- License
- Atribución 2.5
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| dc.title.spa.fl_str_mv |
Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain |
| title |
Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain |
| spellingShingle |
Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain Jatrophane Diterpenes Látex de euphorbia obtusifolia Actividad inhibitoria Cadena respiratoria mitocondrial |
| title_short |
Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain |
| title_full |
Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain |
| title_fullStr |
Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain |
| title_full_unstemmed |
Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain |
| title_sort |
Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain |
| dc.creator.fl_str_mv |
Betancur Galvis, Liliana Amparo Checa, Javier Marco Ventura, Juan Alberto Estornell, Ernesto |
| dc.contributor.author.none.fl_str_mv |
Betancur Galvis, Liliana Amparo Checa, Javier Marco Ventura, Juan Alberto Estornell, Ernesto |
| dc.subject.none.fl_str_mv |
Jatrophane Diterpenes Látex de euphorbia obtusifolia Actividad inhibitoria Cadena respiratoria mitocondrial |
| topic |
Jatrophane Diterpenes Látex de euphorbia obtusifolia Actividad inhibitoria Cadena respiratoria mitocondrial |
| description |
ABSTARCT: Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2,2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2.3-bis(2-methylbutyrate), was the most potent inhibitor with an inhibitory concentration (IC50) value of 5.1 ± 0.2 µM. In the present study, some structure-activity trends are suggested for the inhibitory activity of these natural products on the mammalian mitochondrial respiratory chain. |
| publishDate |
2003 |
| dc.date.issued.none.fl_str_mv |
2003 |
| dc.date.accessioned.none.fl_str_mv |
2017-10-10T16:53:50Z |
| dc.date.available.none.fl_str_mv |
2017-10-10T16:53:50Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Betancur Galvis, L. A., Checa, J., Marco Ventura, J. A., & Estornell, E. Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Planta Médica. 2003; 69: 177-178. |
| dc.identifier.issn.none.fl_str_mv |
0032-0943 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/8522 |
| dc.identifier.eissn.none.fl_str_mv |
1439-0221 |
| identifier_str_mv |
Betancur Galvis, L. A., Checa, J., Marco Ventura, J. A., & Estornell, E. Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Planta Médica. 2003; 69: 177-178. 0032-0943 1439-0221 |
| url |
http://hdl.handle.net/10495/8522 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Planta Med |
| dc.rights.*.fl_str_mv |
Atribución 2.5 |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/2.5/co/ |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by/4.0/ |
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Atribución 2.5 http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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| dc.publisher.spa.fl_str_mv |
Georg Thieme Verlag |
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Centro de de Investigaciones Dermatologicas Infección y Cáncer |
| dc.publisher.place.spa.fl_str_mv |
Alemania |
| institution |
Universidad de Antioquia |
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Betancur Galvis, Liliana AmparoCheca, JavierMarco Ventura, Juan AlbertoEstornell, Ernesto2017-10-10T16:53:50Z2017-10-10T16:53:50Z2003Betancur Galvis, L. A., Checa, J., Marco Ventura, J. A., & Estornell, E. Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Planta Médica. 2003; 69: 177-178.0032-0943http://hdl.handle.net/10495/85221439-0221ABSTARCT: Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2,2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2.3-bis(2-methylbutyrate), was the most potent inhibitor with an inhibitory concentration (IC50) value of 5.1 ± 0.2 µM. In the present study, some structure-activity trends are suggested for the inhibitory activity of these natural products on the mammalian mitochondrial respiratory chain.1application/pdfengGeorg Thieme VerlagCentro de de Investigaciones DermatologicasInfección y CáncerAlemaniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución 2.5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Jatrophane DiterpenesLátex de euphorbia obtusifoliaActividad inhibitoriaCadena respiratoria mitocondrialJatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chainPlanta MedPlanta Medica177178692ORIGINALBetancurLiliana_2003_ JatrophaneDiterpenesLatex.pdfBetancurLiliana_2003_ JatrophaneDiterpenesLatex.pdfArtículo de Revistaapplication/pdf72018http://bibliotecadigital.udea.edu.co/bitstream/10495/8522/1/BetancurLiliana_2003_%20JatrophaneDiterpenesLatex.pdf52da9da8d9a6596ec175f21f52281d8bMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/8522/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/8522/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/8522/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/8522/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/8522oai:bibliotecadigital.udea.edu.co:10495/85222021-03-22 20:07:49.752Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |