Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model
ABSTRACT: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16,23”), showed promising result...
- Autores:
-
Henao Duque, Ana María
Rodríguez, Berardo de Jesús
Pereañez Jiménes, Jaime Andres
Lobo Echeverri, Tatiana
Núñez Rangel, Vitelbina
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/20243
- Acceso en línea:
- http://hdl.handle.net/10495/20243
- Palabra clave:
- Toxicología
Toxicology
Toxicidad Aguda
Acute Toxicity
Swietenia macrophylla
Extractos de hoja
Leaf extracts
http://aims.fao.org/aos/agrovoc/c_32552
http://aims.fao.org/aos/agrovoc/c_35308
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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|
dc.title.spa.fl_str_mv |
Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model |
dc.title.alternative.spa.fl_str_mv |
Determinación de la toxicidad aguda oral de una fracción rica en compuestos fenólicos del extracto de hojas de swietenia macrophylla king en un modelo murino |
title |
Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model |
spellingShingle |
Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model Toxicología Toxicology Toxicidad Aguda Acute Toxicity Swietenia macrophylla Extractos de hoja Leaf extracts http://aims.fao.org/aos/agrovoc/c_32552 http://aims.fao.org/aos/agrovoc/c_35308 |
title_short |
Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model |
title_full |
Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model |
title_fullStr |
Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model |
title_full_unstemmed |
Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model |
title_sort |
Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine Model |
dc.creator.fl_str_mv |
Henao Duque, Ana María Rodríguez, Berardo de Jesús Pereañez Jiménes, Jaime Andres Lobo Echeverri, Tatiana Núñez Rangel, Vitelbina |
dc.contributor.author.none.fl_str_mv |
Henao Duque, Ana María Rodríguez, Berardo de Jesús Pereañez Jiménes, Jaime Andres Lobo Echeverri, Tatiana Núñez Rangel, Vitelbina |
dc.subject.decs.none.fl_str_mv |
Toxicología Toxicology Toxicidad Aguda Acute Toxicity |
topic |
Toxicología Toxicology Toxicidad Aguda Acute Toxicity Swietenia macrophylla Extractos de hoja Leaf extracts http://aims.fao.org/aos/agrovoc/c_32552 http://aims.fao.org/aos/agrovoc/c_35308 |
dc.subject.agrovoc.none.fl_str_mv |
Swietenia macrophylla Extractos de hoja Leaf extracts |
dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_32552 http://aims.fao.org/aos/agrovoc/c_35308 |
description |
ABSTRACT: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16,23”), showed promising results against some toxins of South American pit vipers. Objective: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16,23 from the leaf ethanolic extract, using Swiss Webster mice. Materials and Methods: Fraction Sm13-16,23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/Kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and the binucleation were observed. Conclusion: Fraction Sm13-16,23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low. |
publishDate |
2017 |
dc.date.issued.none.fl_str_mv |
2017 |
dc.date.accessioned.none.fl_str_mv |
2021-06-22T19:55:21Z |
dc.date.available.none.fl_str_mv |
2021-06-22T19:55:21Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
0121-4004 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/20243 |
dc.identifier.doi.none.fl_str_mv |
10.17533/udea.vitae.v24n1a03 |
dc.identifier.eissn.none.fl_str_mv |
2145-2660 |
identifier_str_mv |
0121-4004 10.17533/udea.vitae.v24n1a03 2145-2660 |
url |
http://hdl.handle.net/10495/20243 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Vitae |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.extent.spa.fl_str_mv |
7 |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Universidad de Antioquia, Facultad de Ciencias Farmacéuticas y Alimentarias |
dc.publisher.group.spa.fl_str_mv |
Grupo de Investigación en Patobiología – QUIRÓN Toxinología Alternativas Terapéuticas y Alimentarias |
dc.publisher.place.spa.fl_str_mv |
Medellín, Colombia |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/20243/1/Perea%c3%b1ezJaime_2017_AcuteOralToxicity.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/20243/2/license_rdf http://bibliotecadigital.udea.edu.co/bitstream/10495/20243/3/license.txt |
bitstream.checksum.fl_str_mv |
d3f7d80d114c4732d8c0ffc63ea4fcc3 e2060682c9c70d4d30c83c51448f4eed 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
_version_ |
1812173102615887872 |
spelling |
Henao Duque, Ana MaríaRodríguez, Berardo de JesúsPereañez Jiménes, Jaime AndresLobo Echeverri, TatianaNúñez Rangel, Vitelbina2021-06-22T19:55:21Z2021-06-22T19:55:21Z20170121-4004http://hdl.handle.net/10495/2024310.17533/udea.vitae.v24n1a032145-2660ABSTRACT: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16,23”), showed promising results against some toxins of South American pit vipers. Objective: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16,23 from the leaf ethanolic extract, using Swiss Webster mice. Materials and Methods: Fraction Sm13-16,23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/Kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and the binucleation were observed. Conclusion: Fraction Sm13-16,23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low.RESUMEN: El árbol de la caoba (Swietenia macrophylla King) es utilizado ampliamente en la medicina tradicional, especialmente sus semillas, que son usadas en Malasia, Indonesia y algunos países de Suramérica. Recientemente una fracción activa del extracto etanólico de las hojas (llamada “Sm13-16,23”), demostró resultados promisorios frente algunas toxinas de las víboras suramericanas. Objetivos: En este estudio se evaluó la toxicidad aguda oral de la fracción Sm13-16,23 del extracto etanólico de las hojas de S. macrophylla utilizando ratones Swiss Webster. Métodos: La fracción Sm13-16,23 se administró vía oral como dosis única a 2000 mg/kg y 300 mg/kg, se realizó seguimiento clínico de los animales durante 14 días y finalmente se les aplicó la eutanasia. Se practicó la necropsia de cada animal y se tomaron algunos órganos para su evaluación histopatológica. Resultados: No se registraron muertes durante el tiempo de estudio, ni se evidenciaron signos de toxicidad a dosis de 300mg/kg, sin embargo, a la dosis de 2000 mg/kg, se encontraron lesiones histopatológicas en el hígado; como cariomegalia y binucleación de los hepatocitos. Conclusión: La fracción Sm13-16,23 no produjo lesiones de toxicidad a dosis de 300mg/ kg, lo que indicia que el riesgo de toxicidad aguda oral es bajo.COL0014476COL00929647application/pdfengUniversidad de Antioquia, Facultad de Ciencias Farmacéuticas y AlimentariasGrupo de Investigación en Patobiología – QUIRÓNToxinología Alternativas Terapéuticas y AlimentariasMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Acute Oral Toxicity from a Fraction Rich in Phenolic Compounds from the Leaf Extract of Swietenia macrophylla King in a Murine ModelDeterminación de la toxicidad aguda oral de una fracción rica en compuestos fenólicos del extracto de hojas de swietenia macrophylla king en un modelo murinoToxicologíaToxicologyToxicidad AgudaAcute ToxicitySwietenia macrophyllaExtractos de hojaLeaf extractshttp://aims.fao.org/aos/agrovoc/c_32552http://aims.fao.org/aos/agrovoc/c_35308VitaeVitae2329241ORIGINALPereañezJaime_2017_AcuteOralToxicity.pdfPereañezJaime_2017_AcuteOralToxicity.pdfArtículo de investigaciónapplication/pdf902322http://bibliotecadigital.udea.edu.co/bitstream/10495/20243/1/Perea%c3%b1ezJaime_2017_AcuteOralToxicity.pdfd3f7d80d114c4732d8c0ffc63ea4fcc3MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051http://bibliotecadigital.udea.edu.co/bitstream/10495/20243/2/license_rdfe2060682c9c70d4d30c83c51448f4eedMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/20243/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/20243oai:bibliotecadigital.udea.edu.co:10495/202432021-06-22 14:55:22.145Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |