Terapia con células madre en cirrosis
ABSTRACT: We present a review of the literature on stem cells as therapy for cirrhosis. We emphasize on a description of the present scientific status of the field and its clinical implications. Cell therapy has been proposed in view of the shortage of liver organ donors, and the complications of im...
- Autores:
-
Londoño Agudelo, Jessica María
Niño Pulido, César Daniel
Hoyos Vanegas, Natalia Andrea
Restrepo Gutiérrez, Juan Carlos
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12669
- Acceso en línea:
- http://hdl.handle.net/10495/12669
- Palabra clave:
- Células Madre
Cirrosis Hepática
Trasplante Celular
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
| id |
UDEA2_6ff2cc966bf8ee54602348b96a5d35bc |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/12669 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Terapia con células madre en cirrosis |
| dc.title.alternative.spa.fl_str_mv |
Stem cell therapy in cirrhosis |
| title |
Terapia con células madre en cirrosis |
| spellingShingle |
Terapia con células madre en cirrosis Células Madre Cirrosis Hepática Trasplante Celular |
| title_short |
Terapia con células madre en cirrosis |
| title_full |
Terapia con células madre en cirrosis |
| title_fullStr |
Terapia con células madre en cirrosis |
| title_full_unstemmed |
Terapia con células madre en cirrosis |
| title_sort |
Terapia con células madre en cirrosis |
| dc.creator.fl_str_mv |
Londoño Agudelo, Jessica María Niño Pulido, César Daniel Hoyos Vanegas, Natalia Andrea Restrepo Gutiérrez, Juan Carlos |
| dc.contributor.author.none.fl_str_mv |
Londoño Agudelo, Jessica María Niño Pulido, César Daniel Hoyos Vanegas, Natalia Andrea Restrepo Gutiérrez, Juan Carlos |
| dc.subject.none.fl_str_mv |
Células Madre Cirrosis Hepática Trasplante Celular |
| topic |
Células Madre Cirrosis Hepática Trasplante Celular |
| description |
ABSTRACT: We present a review of the literature on stem cells as therapy for cirrhosis. We emphasize on a description of the present scientific status of the field and its clinical implications. Cell therapy has been proposed in view of the shortage of liver organ donors, and the complications of immunosuppressive therapy. Stem cells may be obtained from different sources such as the blastocyst, bone marrow and even mature hepatocytes. The ability to proliferate and differentiate varies among these cell types. Such variations, among other factors, influence their clinical utility. The safety and feasibility of this technique to improve fibrosis, the ability of the cells to differentiate and replicate, and some clinical parameters have been assessed in both animal models and human beings. Results, although encouraging, should be carefully interpreted. In conclusion, further studies are required on stem cell therapy for cirrhosis because it is still a controversial field. |
| publishDate |
2011 |
| dc.date.issued.none.fl_str_mv |
2011 |
| dc.date.accessioned.none.fl_str_mv |
2019-12-20T16:47:43Z |
| dc.date.available.none.fl_str_mv |
2019-12-20T16:47:43Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_dcae04bc |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ARTREV |
| dc.type.local.spa.fl_str_mv |
Artículo de revisión |
| format |
http://purl.org/coar/resource_type/c_dcae04bc |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Londoño Agudelo JM, Niño Pulido CD, Hoyos Vanegas NA, Restrepo Gutiérrez JC. Terapia con células madre en cirrosis. Iatreia. 2011 Dic;24(4): 378 - 389. |
| dc.identifier.issn.none.fl_str_mv |
0121-0793 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/12669 |
| dc.identifier.eissn.none.fl_str_mv |
2011-7965 |
| identifier_str_mv |
Londoño Agudelo JM, Niño Pulido CD, Hoyos Vanegas NA, Restrepo Gutiérrez JC. Terapia con células madre en cirrosis. Iatreia. 2011 Dic;24(4): 378 - 389. 0121-0793 2011-7965 |
| url |
http://hdl.handle.net/10495/12669 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Iatreia |
| dc.rights.*.fl_str_mv |
Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
| dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| rights_invalid_str_mv |
Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) https://creativecommons.org/licenses/by-nc-sa/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
11 |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Universidad de Antioquia, Facultad de Medicina |
| dc.publisher.place.spa.fl_str_mv |
Medellín, Colombia |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/1/Londo%c3%b1oJ%c3%a9ssica_2011_TerapiaC%c3%a9lulasCirrosis.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/5/license.txt http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/2/license_url http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/3/license_text http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/4/license_rdf |
| bitstream.checksum.fl_str_mv |
038006560f46400b9ffe1bfd0cda2a51 8a4605be74aa9ea9d79846c1fba20a33 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
| repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
| _version_ |
1812173144012619776 |
| spelling |
Londoño Agudelo, Jessica MaríaNiño Pulido, César DanielHoyos Vanegas, Natalia AndreaRestrepo Gutiérrez, Juan Carlos2019-12-20T16:47:43Z2019-12-20T16:47:43Z2011Londoño Agudelo JM, Niño Pulido CD, Hoyos Vanegas NA, Restrepo Gutiérrez JC. Terapia con células madre en cirrosis. Iatreia. 2011 Dic;24(4): 378 - 389.0121-0793http://hdl.handle.net/10495/126692011-7965ABSTRACT: We present a review of the literature on stem cells as therapy for cirrhosis. We emphasize on a description of the present scientific status of the field and its clinical implications. Cell therapy has been proposed in view of the shortage of liver organ donors, and the complications of immunosuppressive therapy. Stem cells may be obtained from different sources such as the blastocyst, bone marrow and even mature hepatocytes. The ability to proliferate and differentiate varies among these cell types. Such variations, among other factors, influence their clinical utility. The safety and feasibility of this technique to improve fibrosis, the ability of the cells to differentiate and replicate, and some clinical parameters have been assessed in both animal models and human beings. Results, although encouraging, should be carefully interpreted. In conclusion, further studies are required on stem cell therapy for cirrhosis because it is still a controversial field.RESUMEN: En este artículo se presenta una revisión de la literatura sobre las células madre como terapia para la cirrosis hepática, con énfasis en describir la situación científica actual y las implicaciones clínicas de los avances. Se ha propuesto la terapia celular en cirrosis por la escasez de donantes de hígado y las complicaciones derivadas de la terapia inmunosupresora. Las células madre se pueden obtener de diferentes fuentes como el blastocisto, la médula ósea e incluso hepatocitos maduros; pero la capacidad de proliferación y diferenciación de cada uno de estos tipos celulares es distinta y, entre otras consideraciones, es lo que va a definir su utilidad clínica final. En la literatura se encuentran varios estudios en modelos animales y en seres humanos que evalúan la seguridad y factibilidad de esta técnica en cuanto a la mejoría de la fibrosis, la capacidad de diferenciación y replicación celulares y algunos parámetros clínicos. Los resultados, aunque alentadores, se deben interpretar con cuidado. En conclusión, antes de aceptar esta modalidad terapéutica se requieren estudios de mejor calidad y con homogeneidad metodológica porque su uso aún es controversial.11application/pdfspaUniversidad de Antioquia, Facultad de MedicinaMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVArtículo de revisiónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Células MadreCirrosis HepáticaTrasplante CelularTerapia con células madre en cirrosisStem cell therapy in cirrhosisIatreiaIatreia378389243ORIGINALLondoñoJéssica_2011_TerapiaCélulasCirrosis.pdfLondoñoJéssica_2011_TerapiaCélulasCirrosis.pdfArtículo de revisiónapplication/pdf1113216http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/1/Londo%c3%b1oJ%c3%a9ssica_2011_TerapiaC%c3%a9lulasCirrosis.pdf038006560f46400b9ffe1bfd0cda2a51MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/12669/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD5410495/12669oai:bibliotecadigital.udea.edu.co:10495/126692021-03-23 08:46:58.014Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |