Histoplasmosis : results of the Colombian National Survey, 1992-2008

ABSTRACT : Introduction. Histoplasmosis, a fungal disorder characterized by a wide spectrum of manifestations that range from subclinical infections to disseminated processes, affects both immunocompetent and immunosuppressed individuals. Histoplasmosis is not a reportable disease in Colombia and co...

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Autores:
Arango Arteaga, Myrtha
Castañeda, Elizabeth
Agudelo, Clara Inés
Bedout Gómez, Catalina de
Agudelo Restrepo, Carlos Andrés
Tobón Orozco, Ángela María
Linares Linares, Melva
Valencia Alzate, Yorlady
Restrepo Moreno, Ángela
Tipo de recurso:
Article of investigation
Fecha de publicación:
2011
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/29313
Acceso en línea:
http://hdl.handle.net/10495/29313
Palabra clave:
Histoplasmosis
Vigilancia Inmunológica
Immunologic Surveillance
Niños
Children
Colombia
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_6dc06aebc11c0ad759b8141f47d6a775
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/29313
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Histoplasmosis : results of the Colombian National Survey, 1992-2008
dc.title.alternative.spa.fl_str_mv Histoplasmosis en Colombia : resultados de la encuesta nacional, 1992-2008
title Histoplasmosis : results of the Colombian National Survey, 1992-2008
spellingShingle Histoplasmosis : results of the Colombian National Survey, 1992-2008
Histoplasmosis
Vigilancia Inmunológica
Immunologic Surveillance
Niños
Children
Colombia
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
title_short Histoplasmosis : results of the Colombian National Survey, 1992-2008
title_full Histoplasmosis : results of the Colombian National Survey, 1992-2008
title_fullStr Histoplasmosis : results of the Colombian National Survey, 1992-2008
title_full_unstemmed Histoplasmosis : results of the Colombian National Survey, 1992-2008
title_sort Histoplasmosis : results of the Colombian National Survey, 1992-2008
dc.creator.fl_str_mv Arango Arteaga, Myrtha
Castañeda, Elizabeth
Agudelo, Clara Inés
Bedout Gómez, Catalina de
Agudelo Restrepo, Carlos Andrés
Tobón Orozco, Ángela María
Linares Linares, Melva
Valencia Alzate, Yorlady
Restrepo Moreno, Ángela
dc.contributor.author.none.fl_str_mv Arango Arteaga, Myrtha
Castañeda, Elizabeth
Agudelo, Clara Inés
Bedout Gómez, Catalina de
Agudelo Restrepo, Carlos Andrés
Tobón Orozco, Ángela María
Linares Linares, Melva
Valencia Alzate, Yorlady
Restrepo Moreno, Ángela
dc.subject.decs.none.fl_str_mv Histoplasmosis
Vigilancia Inmunológica
Immunologic Surveillance
Niños
Children
Colombia
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
topic Histoplasmosis
Vigilancia Inmunológica
Immunologic Surveillance
Niños
Children
Colombia
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
description ABSTRACT : Introduction. Histoplasmosis, a fungal disorder characterized by a wide spectrum of manifestations that range from subclinical infections to disseminated processes, affects both immunocompetent and immunosuppressed individuals. Histoplasmosis is not a reportable disease in Colombia and consequently, a survey was designed to collect histoplasmosis cases diagnosed in the country. Objective. The aim of this work was to analyze the data collected from 1992 to 2008. Materials and methods. The survey included demographic data, risk factors, clinical manifestations, imaging data, diagnostic methods and antifungal treatment. Patients were grouped according to risk factors and comparisons of the various findings were done. Results. A total of 434 surveys were gathered from 20 of the country’s Departments. Most patients (96.1%) were adults, 77% were males with a mean age of 38.4 years. Only 3.9% were children less than 15 years of age. In the adult population, AIDS was reported in 70.5% of the cases; additionally, in 7.0% patients other immunosuppressive conditions were informed. The most frequent clinical manifestations were fever (76.1%), cough (54.8%) and constitutional symptoms (56.8%). X rays abnormalities were represented mainly by infiltrates (65.9%) and nodules (17.1%). Diagnosis was made by microscopic observation of H. capsulatum in 49.6% patients, by culture in 58.0% and by serological test in 14.6% cases. Antifungal use was recorded in 52.5% cases. Conclusions. Histoplasmosis is frequent in Colombia, especially in certain risk factor groups such as the HIV-infected population. Data collected from this large number of cases has allowed valid comparisons on various aspects of histoplasmosis in Colombia.
publishDate 2011
dc.date.issued.none.fl_str_mv 2011
dc.date.accessioned.none.fl_str_mv 2022-06-19T22:32:19Z
dc.date.available.none.fl_str_mv 2022-06-19T22:32:19Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.spa.fl_str_mv Arango M, Castañeda E, Agudelo CI, De Bedout C, Agudelo CA, Tobón A, Linares M, Valencia Y, Restrepo Ángela, Study Group TCH. Histoplasmosis en Colombia: resultados de la encuesta nacional, 1992-2008. biomedica [Internet]. 1 [citado 19 de junio de 2022];31(3):344-56. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/348
dc.identifier.issn.none.fl_str_mv 0120-4157
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/29313
dc.identifier.doi.none.fl_str_mv 10.7705/biomedica.v31i3.348
dc.identifier.eissn.none.fl_str_mv 2590-7379
identifier_str_mv Arango M, Castañeda E, Agudelo CI, De Bedout C, Agudelo CA, Tobón A, Linares M, Valencia Y, Restrepo Ángela, Study Group TCH. Histoplasmosis en Colombia: resultados de la encuesta nacional, 1992-2008. biomedica [Internet]. 1 [citado 19 de junio de 2022];31(3):344-56. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/348
0120-4157
10.7705/biomedica.v31i3.348
2590-7379
url http://hdl.handle.net/10495/29313
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Biomédica
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.extent.spa.fl_str_mv 18
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Instituto Nacional de Salud
dc.publisher.group.spa.fl_str_mv Micología Médica y Experimental
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
institution Universidad de Antioquia
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spelling Arango Arteaga, MyrthaCastañeda, ElizabethAgudelo, Clara InésBedout Gómez, Catalina deAgudelo Restrepo, Carlos AndrésTobón Orozco, Ángela MaríaLinares Linares, MelvaValencia Alzate, YorladyRestrepo Moreno, Ángela2022-06-19T22:32:19Z2022-06-19T22:32:19Z2011Arango M, Castañeda E, Agudelo CI, De Bedout C, Agudelo CA, Tobón A, Linares M, Valencia Y, Restrepo Ángela, Study Group TCH. Histoplasmosis en Colombia: resultados de la encuesta nacional, 1992-2008. biomedica [Internet]. 1 [citado 19 de junio de 2022];31(3):344-56. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/3480120-4157http://hdl.handle.net/10495/2931310.7705/biomedica.v31i3.3482590-7379ABSTRACT : Introduction. Histoplasmosis, a fungal disorder characterized by a wide spectrum of manifestations that range from subclinical infections to disseminated processes, affects both immunocompetent and immunosuppressed individuals. Histoplasmosis is not a reportable disease in Colombia and consequently, a survey was designed to collect histoplasmosis cases diagnosed in the country. Objective. The aim of this work was to analyze the data collected from 1992 to 2008. Materials and methods. The survey included demographic data, risk factors, clinical manifestations, imaging data, diagnostic methods and antifungal treatment. Patients were grouped according to risk factors and comparisons of the various findings were done. Results. A total of 434 surveys were gathered from 20 of the country’s Departments. Most patients (96.1%) were adults, 77% were males with a mean age of 38.4 years. Only 3.9% were children less than 15 years of age. In the adult population, AIDS was reported in 70.5% of the cases; additionally, in 7.0% patients other immunosuppressive conditions were informed. The most frequent clinical manifestations were fever (76.1%), cough (54.8%) and constitutional symptoms (56.8%). X rays abnormalities were represented mainly by infiltrates (65.9%) and nodules (17.1%). Diagnosis was made by microscopic observation of H. capsulatum in 49.6% patients, by culture in 58.0% and by serological test in 14.6% cases. Antifungal use was recorded in 52.5% cases. Conclusions. Histoplasmosis is frequent in Colombia, especially in certain risk factor groups such as the HIV-infected population. Data collected from this large number of cases has allowed valid comparisons on various aspects of histoplasmosis in Colombia.RESUMEN : Introducción. La histoplasmosis está caracterizada por variadas manifestaciones que van desde la afección subclínica a la enfermedad diseminada, y suele presentarse tanto en huéspedes inmunocompetentes como inmunosuprimidos. Como la enfermedad no es de notificación obligatoria en Colombia, se diseñó una encuesta para recolectar información de los casos diagnosticados en el país. Objetivo. El objetivo de este trabajo fue analizar los datos recolectados desde 1992 hasta 2008. Materiales y métodos. La encuesta incluyó datos demográficos, factores de riesgo, manifestaciones clínicas, estudios de imágenes, métodos diagnósticos y tratamiento antifúngico. Los pacientes se agruparon de acuerdo con los factores de riesgo y se compararon los correspondientes hallazgos. Resultados. Se examinaron 434 encuestas provenientes de 20 de los departamentos colombianos. La mayoría (96,1 %) correspondían a adultos, 77 % eran hombres con edad promedio de 38,4 años, y sólo 3,9 % eran niños o adolescentes. En los adultos, 70,5 % tenían sida y 7 % presentaban otra inmunosupresión. Las manifestaciones predominantes fueron fiebre (76,1 %), tos (54,8 %) y síntomas constitucionales (56,8 %). En las radiografías, las anormalidades fueron principalmente infiltrados (65,9 %) y nódulos (17,1 %). El diagnóstico se estableció por observación microscópica de H. capsulatum en 49,6 % casos, por cultivo en 58 % y por pruebas serológicas en 14,6 %. El tratamiento se informó sólo en 52,5 % casos. Conclusiones. Se demostró que la histoplasmosis es frecuente en Colombia, especialmente en grupos de riesgo como son los pacientes infectados con el VIH. El análisis de este número relevante de pacientes permitió establecer comparaciones válidas sobre aspectos de la histoplasmosis en nuestro país.COL001370918application/pdfengInstituto Nacional de SaludMicología Médica y ExperimentalBogotá, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Histoplasmosis : results of the Colombian National Survey, 1992-2008Histoplasmosis en Colombia : resultados de la encuesta nacional, 1992-2008HistoplasmosisVigilancia InmunológicaImmunologic SurveillanceNiñosChildrenColombiaSíndrome de Inmunodeficiencia AdquiridaAcquired Immunodeficiency SyndromeBiomédicaBiomédica344356313CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/29313/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/29313/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53ORIGINALArangoMyrtha_2011_Histoplasmosis_Colombia.pdfArangoMyrtha_2011_Histoplasmosis_Colombia.pdfArtículo de investigaciónapplication/pdf397289https://bibliotecadigital.udea.edu.co/bitstream/10495/29313/1/ArangoMyrtha_2011_Histoplasmosis_Colombia.pdf6b5b0438171c6693b0969a9076c8d41fMD5110495/29313oai:bibliotecadigital.udea.edu.co:10495/293132022-06-19 17:32:19.675Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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