Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s
ABSTRACT: Background: Alzheimer’s disease is the most leading cause of dementia in the world; the mutation PS-1 E280A alters the gene of the Presenilin-1 and causes an early onset familial Alzheimer’s disease. This mutation has been found in large kindred of Antioquia, Colombia. The objective of thi...
- Autores:
-
Duque Grajales, Jon Edinson
Tobón Quintero, Carlos Andrés
Aponte Restrepo, Claudia
Ochoa Gómez, John Fredy
Muñoz Zapata, Claudia Cecilia
Hernández Valdivieso, Alher Mauricio
Quiroz Zapata, Yakeel
Lopera Restrepo, Francisco Javier
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/25669
- Acceso en línea:
- http://hdl.handle.net/10495/25669
https://revistas.ces.edu.co/index.php/medicina/article/view/2897/
- Palabra clave:
- Enfermedad de Alzheimer
Alzheimer Disease
Electroencefalografía
Electroencephalography
Análisis espectral
Spectrum Analysis
PS-1 E280A mutation
Theta frequency bandPower spectrum
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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| dc.title.spa.fl_str_mv |
Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s |
| dc.title.alternative.spa.fl_str_mv |
Análisis del EEG cuantitativo durante tareas de memoria y reposo en portadores y no portadores de la mutación PS-1 E280A de la enfermedad de Alzheimer |
| title |
Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s |
| spellingShingle |
Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s Enfermedad de Alzheimer Alzheimer Disease Electroencefalografía Electroencephalography Análisis espectral Spectrum Analysis PS-1 E280A mutation Theta frequency bandPower spectrum |
| title_short |
Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s |
| title_full |
Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s |
| title_fullStr |
Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s |
| title_full_unstemmed |
Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s |
| title_sort |
Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´s |
| dc.creator.fl_str_mv |
Duque Grajales, Jon Edinson Tobón Quintero, Carlos Andrés Aponte Restrepo, Claudia Ochoa Gómez, John Fredy Muñoz Zapata, Claudia Cecilia Hernández Valdivieso, Alher Mauricio Quiroz Zapata, Yakeel Lopera Restrepo, Francisco Javier |
| dc.contributor.author.none.fl_str_mv |
Duque Grajales, Jon Edinson Tobón Quintero, Carlos Andrés Aponte Restrepo, Claudia Ochoa Gómez, John Fredy Muñoz Zapata, Claudia Cecilia Hernández Valdivieso, Alher Mauricio Quiroz Zapata, Yakeel Lopera Restrepo, Francisco Javier |
| dc.subject.decs.none.fl_str_mv |
Enfermedad de Alzheimer Alzheimer Disease Electroencefalografía Electroencephalography Análisis espectral Spectrum Analysis |
| topic |
Enfermedad de Alzheimer Alzheimer Disease Electroencefalografía Electroencephalography Análisis espectral Spectrum Analysis PS-1 E280A mutation Theta frequency bandPower spectrum |
| dc.subject.proposal.spa.fl_str_mv |
PS-1 E280A mutation Theta frequency bandPower spectrum |
| description |
ABSTRACT: Background: Alzheimer’s disease is the most leading cause of dementia in the world; the mutation PS-1 E280A alters the gene of the Presenilin-1 and causes an early onset familial Alzheimer’s disease. This mutation has been found in large kindred of Antioquia, Colombia. The objective of this study was to find differences revealed by electroencephalogram between healthy subjects and asymptomatic carriers that can be used as clinical markers of the disease in this population. Methods: EEG was recorded in 15 asymptomatic E280A carriers and 15 healthy non carriers during resting and a memory task using 64 channels amplifier. Two conditions in the memory task were analyzed: encoding and retrieval, the process of recording and evocating information, respectively. Power spectrum was calculated in delta (0.5–4.0 Hz), theta (4.0–8. 0 Hz), alpha-1 (8.0–10.0 Hz), alpha-2 (10.0–13.0 Hz), beta (13.0–25.0 Hz) and gamma (25.0–50 Hz) frequency bands for four regions of interest. Changes were evaluated in different conditions by ANOVA analysis. Results: In resting condition a significant decrease was found in theta (p=0. 0001) and an increase in alpha-2 frequencies (p=0.037) in carriers compare with controls. During encoding of the memory task theta was significantly lower in carriers compared with controls (p=0. 008) and comparing resting versus retrieval process for each group, there was more theta synchronization in carriers. Conclusion: Early changes in theta frequencies were observed in the EEG recordings, it could be use as clinical markers in this population. Also it seems carriers activate additional cortical regions in order to conserve successful cognitive functions before clinical impairment. |
| publishDate |
2014 |
| dc.date.issued.none.fl_str_mv |
2014 |
| dc.date.accessioned.none.fl_str_mv |
2022-01-28T14:33:40Z |
| dc.date.available.none.fl_str_mv |
2022-01-28T14:33:40Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.local.spa.fl_str_mv |
Artículo de investigación |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.issn.none.fl_str_mv |
0120-8705 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/25669 |
| dc.identifier.eissn.none.fl_str_mv |
2215-9177 |
| dc.identifier.url.spa.fl_str_mv |
https://revistas.ces.edu.co/index.php/medicina/article/view/2897/ |
| identifier_str_mv |
0120-8705 2215-9177 |
| url |
http://hdl.handle.net/10495/25669 https://revistas.ces.edu.co/index.php/medicina/article/view/2897/ |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
CES med. |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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11 |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Universidad CES, Facultad de Medicina |
| dc.publisher.group.spa.fl_str_mv |
Grupo de Investigación en Bioinstrumentación e Ingeniería Clínica (GIBIC) Grupo de Neurociencias de Antioquia Grupo Neuropsicología y Conducta |
| dc.publisher.place.spa.fl_str_mv |
Medellín, Colombia |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstream/10495/25669/1/DuqueJon_2014_QuantitativeEEGAnalysis.pdf https://bibliotecadigital.udea.edu.co/bitstream/10495/25669/2/license_rdf https://bibliotecadigital.udea.edu.co/bitstream/10495/25669/3/license.txt |
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andres.perez@udea.edu.co |
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1812173295965962240 |
| spelling |
Duque Grajales, Jon EdinsonTobón Quintero, Carlos AndrésAponte Restrepo, ClaudiaOchoa Gómez, John FredyMuñoz Zapata, Claudia CeciliaHernández Valdivieso, Alher MauricioQuiroz Zapata, YakeelLopera Restrepo, Francisco Javier2022-01-28T14:33:40Z2022-01-28T14:33:40Z20140120-8705http://hdl.handle.net/10495/256692215-9177https://revistas.ces.edu.co/index.php/medicina/article/view/2897/ABSTRACT: Background: Alzheimer’s disease is the most leading cause of dementia in the world; the mutation PS-1 E280A alters the gene of the Presenilin-1 and causes an early onset familial Alzheimer’s disease. This mutation has been found in large kindred of Antioquia, Colombia. The objective of this study was to find differences revealed by electroencephalogram between healthy subjects and asymptomatic carriers that can be used as clinical markers of the disease in this population. Methods: EEG was recorded in 15 asymptomatic E280A carriers and 15 healthy non carriers during resting and a memory task using 64 channels amplifier. Two conditions in the memory task were analyzed: encoding and retrieval, the process of recording and evocating information, respectively. Power spectrum was calculated in delta (0.5–4.0 Hz), theta (4.0–8. 0 Hz), alpha-1 (8.0–10.0 Hz), alpha-2 (10.0–13.0 Hz), beta (13.0–25.0 Hz) and gamma (25.0–50 Hz) frequency bands for four regions of interest. Changes were evaluated in different conditions by ANOVA analysis. Results: In resting condition a significant decrease was found in theta (p=0. 0001) and an increase in alpha-2 frequencies (p=0.037) in carriers compare with controls. During encoding of the memory task theta was significantly lower in carriers compared with controls (p=0. 008) and comparing resting versus retrieval process for each group, there was more theta synchronization in carriers. Conclusion: Early changes in theta frequencies were observed in the EEG recordings, it could be use as clinical markers in this population. Also it seems carriers activate additional cortical regions in order to conserve successful cognitive functions before clinical impairment.RESUMEN: Introducción: la enfermedad de Alzheimer es la principal causa de demencia en el mundo; la mutación PS-1 E280A altera el gen presenilin-1 y causa una variante familiar de la enfermedad que se caracteriza por una aparición temprana. La mutación se ha descubierto en un grupo de familias de Antioquia, Colombia. El objetivo de este estudio fue encontrar diferencias, a partir de registros electroencefalográficos de personas portadores de la mutación en una etapa asinto-mática y sujetos sanos para evaluar si pueden ser utilizadas como un marcador temprano de la enfermedad en la población portadora de la mutación. Metodología: se realizaron registros EEG en 15 portadores asintomáticos de la mutación E280A y 15 personas sanas no portadoras du-rante una tarea de memoria y en reposo utili-zando un amplificador de 64 canales. En la tarea de memoria se evaluaron dos condiciones: co-dificación y evocación; el proceso de memorizar y recuperar la información, respectivamente. La potencia espectral fue calculada en las bandas de frecuencia delta (0,5–4,0 Hz), teta (4,0–8,0 Hz), alfa-1 (8,0–10,0 Hz), alfa-2 (10,0–13,0 Hz), beta (13,0–25,0 Hz) y gamma (25,0–50 Hz) para cuatro regiones de interés. Los cambios del es-pectro fueron evaluados por análisis de varianza ANOVA. Resultados: bajo la condición de reposo se en-contró una disminución importante en la poten-cia de la banda teta (p=0,0001) y un incremento en la banda alfa-2 (p=0,037) en portadores com-parados con controles. Durante la tarea de codi-ficación, los portadores mostraron una disminu-ción significativa en la banda teta (p=0,008). Al comparar reposo contra memoria de evocación se encontró una mayor sincronización en teta en los portadores de la mutación. Conclusión: se encontraron cambios tempra-nos de la potencia en la banda teta que pue-den ser utilizados como un marcador clínico de la enfermedad en esta población. Una hipótesis adicional basada en los resultados es que los portadores necesitan activar regiones corticales adicionales para conservar las funciones cogni-tivas antes de empezar un deterioro clínico.COL0010744COL0054963COL000755111application/pdfengUniversidad CES, Facultad de MedicinaGrupo de Investigación en Bioinstrumentación e Ingeniería Clínica (GIBIC)Grupo de Neurociencias de AntioquiaGrupo Neuropsicología y ConductaMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Quantitative EEG analysis disease during resting and memory task in carriers and non-carriers of PS-1 E280A mutation of familial Alzheimer´sAnálisis del EEG cuantitativo durante tareas de memoria y reposo en portadores y no portadores de la mutación PS-1 E280A de la enfermedad de AlzheimerEnfermedad de AlzheimerAlzheimer DiseaseElectroencefalografíaElectroencephalographyAnálisis espectralSpectrum AnalysisPS-1 E280A mutationTheta frequency bandPower spectrumCES med.CES Medicina165175282ORIGINALDuqueJon_2014_QuantitativeEEGAnalysis.pdfDuqueJon_2014_QuantitativeEEGAnalysis.pdfArticulo de investigaciónapplication/pdf3285396https://bibliotecadigital.udea.edu.co/bitstream/10495/25669/1/DuqueJon_2014_QuantitativeEEGAnalysis.pdf8accad8110027c5eba34b8aba1750c54MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/25669/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/25669/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/25669oai:bibliotecadigital.udea.edu.co:10495/256692022-11-13 11:18:09.373Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |