Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives
ABSTRACT: The parasite resistance and side effects of drugs used to treat protozoal diseases have led to the search for new therapies, both natural and synthetic. Studies have shown that various α,β-unsaturated δlactones displayed high antiprotozoal activity and thus are promising compounds for new...
- Autores:
-
Wilson, Cardona Galeano
Saez Vega, Jairo Antonio
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/30994
- Acceso en línea:
- https://hdl.handle.net/10495/30994
https://www.ajol.info/index.php/tjpr/article/view/71710
- Palabra clave:
- Antiparasitarios
Antiparasitic Agents
Lactonas
Lactones
Pironas
Pyrones
Leishmania
Malaria
Plasmodium falciparum
Trypanosoma cruzi
Antiprotozoarios
Antiprotozoal Agents
Enfermedad de Chagas
Chagas Disease
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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| dc.title.spa.fl_str_mv |
Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives |
| title |
Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives |
| spellingShingle |
Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives Antiparasitarios Antiparasitic Agents Lactonas Lactones Pironas Pyrones Leishmania Malaria Plasmodium falciparum Trypanosoma cruzi Antiprotozoarios Antiprotozoal Agents Enfermedad de Chagas Chagas Disease |
| title_short |
Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives |
| title_full |
Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives |
| title_fullStr |
Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives |
| title_full_unstemmed |
Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives |
| title_sort |
Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic Alternatives |
| dc.creator.fl_str_mv |
Wilson, Cardona Galeano Saez Vega, Jairo Antonio |
| dc.contributor.author.none.fl_str_mv |
Wilson, Cardona Galeano Saez Vega, Jairo Antonio |
| dc.subject.decs.none.fl_str_mv |
Antiparasitarios Antiparasitic Agents Lactonas Lactones Pironas Pyrones Leishmania Malaria Plasmodium falciparum Trypanosoma cruzi Antiprotozoarios Antiprotozoal Agents Enfermedad de Chagas Chagas Disease |
| topic |
Antiparasitarios Antiparasitic Agents Lactonas Lactones Pironas Pyrones Leishmania Malaria Plasmodium falciparum Trypanosoma cruzi Antiprotozoarios Antiprotozoal Agents Enfermedad de Chagas Chagas Disease |
| description |
ABSTRACT: The parasite resistance and side effects of drugs used to treat protozoal diseases have led to the search for new therapies, both natural and synthetic. Studies have shown that various α,β-unsaturated δlactones displayed high antiprotozoal activity and thus are promising compounds for new drug discovery and development. These compounds and their activity are examined in this review. |
| publishDate |
2011 |
| dc.date.issued.none.fl_str_mv |
2011 |
| dc.date.accessioned.none.fl_str_mv |
2022-09-30T17:36:31Z |
| dc.date.available.none.fl_str_mv |
2022-09-30T17:36:31Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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1596-5996 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/30994 |
| dc.identifier.doi.none.fl_str_mv |
10.4314/tjpr.v10i5.17 |
| dc.identifier.eissn.none.fl_str_mv |
1596-9827 |
| dc.identifier.url.spa.fl_str_mv |
https://www.ajol.info/index.php/tjpr/article/view/71710 |
| identifier_str_mv |
1596-5996 10.4314/tjpr.v10i5.17 1596-9827 |
| url |
https://hdl.handle.net/10495/30994 https://www.ajol.info/index.php/tjpr/article/view/71710 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Trop. J. Pharm. Res |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/2.5/co/ |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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| dc.publisher.spa.fl_str_mv |
University of Benin, Faculty of Pharmacy |
| dc.publisher.group.spa.fl_str_mv |
Química de Plantas Colombianas |
| dc.publisher.place.spa.fl_str_mv |
Ciudad de Benín, Nigeria |
| institution |
Universidad de Antioquia |
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Wilson, Cardona GaleanoSaez Vega, Jairo Antonio2022-09-30T17:36:31Z2022-09-30T17:36:31Z20111596-5996https://hdl.handle.net/10495/3099410.4314/tjpr.v10i5.171596-9827https://www.ajol.info/index.php/tjpr/article/view/71710ABSTRACT: The parasite resistance and side effects of drugs used to treat protozoal diseases have led to the search for new therapies, both natural and synthetic. Studies have shown that various α,β-unsaturated δlactones displayed high antiprotozoal activity and thus are promising compounds for new drug discovery and development. These compounds and their activity are examined in this review.COL001532910application/pdfengUniversity of Benin, Faculty of PharmacyQuímica de Plantas ColombianasCiudad de Benín, Nigeriainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Antiprotozoal Activity of a,b-Unsaturated Lactones: Promising Compounds for the Development of New Therapeutic AlternativesAntiparasitariosAntiparasitic AgentsLactonasLactonesPironasPyronesLeishmaniaMalariaPlasmodium falciparumTrypanosoma cruziAntiprotozoariosAntiprotozoal AgentsEnfermedad de ChagasChagas DiseaseTrop. J. Pharm. ResTropical Journal of Pharmaceutical671680105ORIGINALCardonaWilson_2011_AntiprotozoalActivityαβUnsaturated.pdfCardonaWilson_2011_AntiprotozoalActivityαβUnsaturated.pdfArtículo de investigaciónapplication/pdf204246https://bibliotecadigital.udea.edu.co/bitstream/10495/30994/1/CardonaWilson_2011_AntiprotozoalActivity%ce%b1%ce%b2Unsaturated.pdf70f53dc36701807af06fdd6f4d2c9651MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927https://bibliotecadigital.udea.edu.co/bitstream/10495/30994/2/license_rdf1646d1f6b96dbbbc38035efc9239ac9cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/30994/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/30994oai:bibliotecadigital.udea.edu.co:10495/309942022-09-30 12:55:21.746Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |