Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer
ABSTRACT: Colorectal Cancer (CRC) is the fourth leading cause of cancer death in the world. Epidemiological studies have shown an association between CRC incidence/mortality with unhealthy dietary habits, which suggests the need to promote and protect health through the adoption of sustainable measu...
- Autores:
-
Arango Varela, Sandra Sulay
Ramírez, Valentina
Maldonado Celis, María Elena
Uribe, Diego
Aguillón Osma, Johanny
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11709
- Acceso en línea:
- http://hdl.handle.net/10495/11709
- Palabra clave:
- Passiflora edulis
Colon cancer
Natural extracts
Phytochemicals
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 2.5 Colombia
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| dc.title.spa.fl_str_mv |
Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer |
| title |
Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer |
| spellingShingle |
Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer Passiflora edulis Colon cancer Natural extracts Phytochemicals |
| title_short |
Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer |
| title_full |
Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer |
| title_fullStr |
Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer |
| title_full_unstemmed |
Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer |
| title_sort |
Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer |
| dc.creator.fl_str_mv |
Arango Varela, Sandra Sulay Ramírez, Valentina Maldonado Celis, María Elena Uribe, Diego Aguillón Osma, Johanny |
| dc.contributor.author.none.fl_str_mv |
Arango Varela, Sandra Sulay Ramírez, Valentina Maldonado Celis, María Elena Uribe, Diego Aguillón Osma, Johanny |
| dc.subject.none.fl_str_mv |
Passiflora edulis Colon cancer Natural extracts Phytochemicals |
| topic |
Passiflora edulis Colon cancer Natural extracts Phytochemicals |
| description |
ABSTRACT: Colorectal Cancer (CRC) is the fourth leading cause of cancer death in the world. Epidemiological studies have shown an association between CRC incidence/mortality with unhealthy dietary habits, which suggests the need to promote and protect health through the adoption of sustainable measures that allow the reduction of morbidity and mortality rates, such as the consumption of products of plant origin. Some phytochemicals derived from fruits have shown antiproliferative activity and high antioxidant capacity; however, few research advances have been obtained regarding the complex mixture of phytochemicals of certain fruits that could contain promising bioactive substances. For these reasons, in the present work we evaluated the cytotoxic activity and the pro-apoptotic potential of the aqueous extract of P. edulis Sims var. Flavicarpa on an in vitro CRC model. Chemical analysis of the extract was based on a preliminary phytochemical screening in which were identified metabolites such as phenolic compounds and sterols, which have displayed antitumoral properties. The extracts exerted cytotoxic and proapoptotic potential, demonstrated by the reduction on cell viability, increase of the SubG0/G1 cell populations and the positive staining with Annexin-V of treated cells. Our results suggest that P. edulis is a potential source of phytochemical compounds with cytotoxic and apoptotic potential over colon cancer cell lines. |
| publishDate |
2017 |
| dc.date.issued.none.fl_str_mv |
2017 |
| dc.date.accessioned.none.fl_str_mv |
2019-08-22T14:38:02Z |
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2019-08-22T14:38:02Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/publishedVersion |
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Artículo de revisión |
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Arango S, Ramírez V, Maldonado M, Uribe D, Aguillón J. Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer. J Chem Pharm Res, 2017; 9(9): 258-64 |
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0975-7384 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/11709 |
| identifier_str_mv |
Arango S, Ramírez V, Maldonado M, Uribe D, Aguillón J. Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer. J Chem Pharm Res, 2017; 9(9): 258-64 0975-7384 |
| url |
http://hdl.handle.net/10495/11709 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
J Chem Pharm Res |
| dc.rights.*.fl_str_mv |
Atribución-NoComercial-SinDerivadas 2.5 Colombia |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Journal of Chemical and Pharmaceutical Research, |
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Impacto de Componentes Alimentarios en la Salud |
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Estados Unidos |
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Universidad de Antioquia |
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andres.perez@udea.edu.co |
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1812173080013832192 |
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Arango Varela, Sandra SulayRamírez, ValentinaMaldonado Celis, María ElenaUribe, DiegoAguillón Osma, Johanny2019-08-22T14:38:02Z2019-08-22T14:38:02Z2017Arango S, Ramírez V, Maldonado M, Uribe D, Aguillón J. Cytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancer. J Chem Pharm Res, 2017; 9(9): 258-640975-7384http://hdl.handle.net/10495/11709ABSTRACT: Colorectal Cancer (CRC) is the fourth leading cause of cancer death in the world. Epidemiological studies have shown an association between CRC incidence/mortality with unhealthy dietary habits, which suggests the need to promote and protect health through the adoption of sustainable measures that allow the reduction of morbidity and mortality rates, such as the consumption of products of plant origin. Some phytochemicals derived from fruits have shown antiproliferative activity and high antioxidant capacity; however, few research advances have been obtained regarding the complex mixture of phytochemicals of certain fruits that could contain promising bioactive substances. For these reasons, in the present work we evaluated the cytotoxic activity and the pro-apoptotic potential of the aqueous extract of P. edulis Sims var. Flavicarpa on an in vitro CRC model. Chemical analysis of the extract was based on a preliminary phytochemical screening in which were identified metabolites such as phenolic compounds and sterols, which have displayed antitumoral properties. The extracts exerted cytotoxic and proapoptotic potential, demonstrated by the reduction on cell viability, increase of the SubG0/G1 cell populations and the positive staining with Annexin-V of treated cells. Our results suggest that P. edulis is a potential source of phytochemical compounds with cytotoxic and apoptotic potential over colon cancer cell lines.application/pdfengJournal of Chemical and Pharmaceutical Research,Impacto de Componentes Alimentarios en la SaludEstados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVArtículo de revisiónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-SinDerivadas 2.5 Colombiainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Passiflora edulisColon cancerNatural extractsPhytochemicalsCytotoxic and apoptotic activities of the aqueous fruit extract of Passiflora edulis Sims var flavicarpa in an in vitro model of human colon cancerJ Chem Pharm ResJournal of Chemical and Pharmaceutical Research25826499ORIGINALArangoSandra_2017_CytotoxicApoptoticActivitiesPassiflora.pdfArangoSandra_2017_CytotoxicApoptoticActivitiesPassiflora.pdfArtículo de revisiónapplication/pdf653708http://bibliotecadigital.udea.edu.co/bitstream/10495/11709/1/ArangoSandra_2017_CytotoxicApoptoticActivitiesPassiflora.pdf38bc1739426b90f323723c722765f79eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/11709/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5210495/11709oai:bibliotecadigital.udea.edu.co:10495/117092021-10-25 13:39:00.289Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |