Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida
ABSTARCT: Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-tr...
- Autores:
-
Galeano Jaramillo, Elkin de Jesús
Thomas, Oliver P.
Robledo Restrepo, Sara María
Muñoz Herrera, Diana Lorena
Martínez Martínez, Alejandro
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/13067
- Acceso en línea:
- http://hdl.handle.net/10495/13067
- Palabra clave:
- Antiparasitarios
Agentes antiparasitarios
Antiparasitic agents
Esponjas
sponges
Bromotirosina
Esponja marina Verongula rigida
http://aims.fao.org/aos/agrovoc/c_7321
- Rights
- openAccess
- License
- Atribución 2.5 Colombia (CC BY 2.5 CO)
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| dc.title.spa.fl_str_mv |
Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida |
| title |
Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida |
| spellingShingle |
Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida Antiparasitarios Agentes antiparasitarios Antiparasitic agents Esponjas sponges Bromotirosina Esponja marina Verongula rigida http://aims.fao.org/aos/agrovoc/c_7321 |
| title_short |
Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida |
| title_full |
Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida |
| title_fullStr |
Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida |
| title_full_unstemmed |
Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida |
| title_sort |
Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida |
| dc.creator.fl_str_mv |
Galeano Jaramillo, Elkin de Jesús Thomas, Oliver P. Robledo Restrepo, Sara María Muñoz Herrera, Diana Lorena Martínez Martínez, Alejandro |
| dc.contributor.author.none.fl_str_mv |
Galeano Jaramillo, Elkin de Jesús Thomas, Oliver P. Robledo Restrepo, Sara María Muñoz Herrera, Diana Lorena Martínez Martínez, Alejandro |
| dc.subject.decs.none.fl_str_mv |
Antiparasitarios |
| topic |
Antiparasitarios Agentes antiparasitarios Antiparasitic agents Esponjas sponges Bromotirosina Esponja marina Verongula rigida http://aims.fao.org/aos/agrovoc/c_7321 |
| dc.subject.lemb.none.fl_str_mv |
Agentes antiparasitarios Antiparasitic agents |
| dc.subject.agrovoc.none.fl_str_mv |
Esponjas sponges |
| dc.subject.proposal.spa.fl_str_mv |
Bromotirosina Esponja marina Verongula rigida |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_7321 |
| description |
ABSTARCT: Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determination of the isolated compounds was performed using one- and two-dimensional NMR, MS and other spectroscopy data. All isolated compounds were screened for their in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compounds 7 and 8 showed selective antiparasitic activity at 10 and 5 μM against Leishmania and Plasmodium parasites, respectively. Cytotoxicity of these compounds on a human promonocytic cell line was also assessed. |
| publishDate |
2011 |
| dc.date.issued.none.fl_str_mv |
2011 |
| dc.date.accessioned.none.fl_str_mv |
2020-01-11T21:30:03Z |
| dc.date.available.none.fl_str_mv |
2020-01-11T21:30:03Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a86 http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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Artículo de investigación |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.citation.spa.fl_str_mv |
Galeano Jaramillo, E. de J., Thomas, O. P., Robledo Restrepo, S. M., Muñoz Herrera, D. L., & Martínez Martínez, A. (2011). Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida. Marine Drugs, 9(10), 1902-1913. https://doi.org/10.3390/md9101902 |
| dc.identifier.issn.none.fl_str_mv |
1660-3397 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/13067 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/md9101902 |
| identifier_str_mv |
Galeano Jaramillo, E. de J., Thomas, O. P., Robledo Restrepo, S. M., Muñoz Herrera, D. L., & Martínez Martínez, A. (2011). Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida. Marine Drugs, 9(10), 1902-1913. https://doi.org/10.3390/md9101902 1660-3397 10.3390/md9101902 |
| url |
http://hdl.handle.net/10495/13067 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Mar. Drugs |
| dc.rights.*.fl_str_mv |
Atribución 2.5 Colombia (CC BY 2.5 CO) |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/2.5/co/ |
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Atribución 2.5 Colombia (CC BY 2.5 CO) https://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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11 |
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application/pdf |
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MDPI |
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Productos Naturales Marinos Programa de Estudio y Control de Enfermedades Tropicales (PECET) |
| dc.publisher.place.spa.fl_str_mv |
Suiza |
| institution |
Universidad de Antioquia |
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Galeano Jaramillo, Elkin de JesúsThomas, Oliver P.Robledo Restrepo, Sara MaríaMuñoz Herrera, Diana LorenaMartínez Martínez, Alejandro2020-01-11T21:30:03Z2020-01-11T21:30:03Z2011Galeano Jaramillo, E. de J., Thomas, O. P., Robledo Restrepo, S. M., Muñoz Herrera, D. L., & Martínez Martínez, A. (2011). Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida. Marine Drugs, 9(10), 1902-1913. https://doi.org/10.3390/md91019021660-3397http://hdl.handle.net/10495/1306710.3390/md9101902ABSTARCT: Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determination of the isolated compounds was performed using one- and two-dimensional NMR, MS and other spectroscopy data. All isolated compounds were screened for their in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compounds 7 and 8 showed selective antiparasitic activity at 10 and 5 μM against Leishmania and Plasmodium parasites, respectively. Cytotoxicity of these compounds on a human promonocytic cell line was also assessed.11application/pdfengMDPIProductos Naturales MarinosPrograma de Estudio y Control de Enfermedades Tropicales (PECET)Suizainfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a86http://purl.org/coar/version/c_970fb48d4fbd8a85Atribución 2.5 Colombia (CC BY 2.5 CO)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigidaAntiparasitariosAgentes antiparasitariosAntiparasitic agentsEsponjasspongesBromotirosinaEsponja marina Verongula rigidahttp://aims.fao.org/aos/agrovoc/c_7321Mar. DrugsMarine Drugs1902191310ORIGINALMartinezAlejandro_2011_AntiparasiticBromotyrosineDerivatives.pdfMartinezAlejandro_2011_AntiparasiticBromotyrosineDerivatives.pdfArtículo de investigaciónapplication/pdf222999https://bibliotecadigital.udea.edu.co/bitstream/10495/13067/1/MartinezAlejandro_2011_AntiparasiticBromotyrosineDerivatives.pdf65c73eb069c613d120df63d01147dd0eMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849https://bibliotecadigital.udea.edu.co/bitstream/10495/13067/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80https://bibliotecadigital.udea.edu.co/bitstream/10495/13067/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80https://bibliotecadigital.udea.edu.co/bitstream/10495/13067/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/13067/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/13067oai:bibliotecadigital.udea.edu.co:10495/130672021-04-29 19:59:12.131Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |