Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle
ABSTRACT: The mammary excretion of fenthion was determined in cross-bred (Bon x Holstein) and pure Holstein cows following a topical (pour-on) application of a commercial formulation. Two groups of five cows each received a single application at the recommended dosage of 10 mg/kg BW on the withers....
- Autores:
-
Ramírez Vásquez, Nicolás Fernando
Ruíz Buitrago, Jhon Didier
Restrepo Betancur, Luis Fernando
López Córdoba, Carlos Alberto
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2009
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/10215
- Acceso en línea:
- http://hdl.handle.net/10495/10215
- Palabra clave:
- Dairy cows
Fenthion residues
Insecticides
Withdrawal time
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
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|
dc.title.spa.fl_str_mv |
Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle |
dc.title.alternative.spa.fl_str_mv |
Cinética de la eliminación de fention en leche luego de una aplicación tópica en dos razas de ganado lechero |
title |
Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle |
spellingShingle |
Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle Dairy cows Fenthion residues Insecticides Withdrawal time |
title_short |
Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle |
title_full |
Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle |
title_fullStr |
Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle |
title_full_unstemmed |
Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle |
title_sort |
Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle |
dc.creator.fl_str_mv |
Ramírez Vásquez, Nicolás Fernando Ruíz Buitrago, Jhon Didier Restrepo Betancur, Luis Fernando López Córdoba, Carlos Alberto |
dc.contributor.author.none.fl_str_mv |
Ramírez Vásquez, Nicolás Fernando Ruíz Buitrago, Jhon Didier Restrepo Betancur, Luis Fernando López Córdoba, Carlos Alberto |
dc.subject.none.fl_str_mv |
Dairy cows Fenthion residues Insecticides Withdrawal time |
topic |
Dairy cows Fenthion residues Insecticides Withdrawal time |
description |
ABSTRACT: The mammary excretion of fenthion was determined in cross-bred (Bon x Holstein) and pure Holstein cows following a topical (pour-on) application of a commercial formulation. Two groups of five cows each received a single application at the recommended dosage of 10 mg/kg BW on the withers. Milk samples were collected twice a day, from the morning and afternoon milkings during a 5-day period and analyzed for fenthion and total fat contents. A bi-compartmental analysis was used to describe the pharmacokinetic parameters. Overall fenthion milk concentrations increased progressively to reach maximum peaks (Cmax) of 0.4 ppm and 0.2 ppm at about 33 hr post-treatment in cross-bred and pure Holstein cows, respectively. However, since total residues in milk were strongly correlated with total fat content, for any particular day the concentrations attained in the morning milking were lower than those for the afternoon collection. The elimination half-lives (T1/2) for the two cattle breeds were 52.5 and 59.3 hr for cross-bred and Holstein respectively as indicated by milk concentrations. Fenthion concentrations declined to the maximum residue limit of 0.05 ppm set by the OMS FAO at 8.0, and 6.61 days post application, in cross-bred and pure bred Holstein cows respectively. These results suggest that withdrawal time for milk from lactating dairy cows treated with topical fenthion, could be of 8 days approximately. |
publishDate |
2009 |
dc.date.issued.none.fl_str_mv |
2009 |
dc.date.accessioned.none.fl_str_mv |
2018-10-06T13:10:59Z |
dc.date.available.none.fl_str_mv |
2018-10-06T13:10:59Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.citation.spa.fl_str_mv |
Ramírez Vásquez NF, Ruíz Buitrago JD, Restrepo LF, López C. Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle. Rev Colomb Cienc Pecu. 2009 Mar; 22(1): 33-41 |
dc.identifier.issn.none.fl_str_mv |
0120-0690 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/10215 |
dc.identifier.eissn.none.fl_str_mv |
2256-2958 |
identifier_str_mv |
Ramírez Vásquez NF, Ruíz Buitrago JD, Restrepo LF, López C. Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle. Rev Colomb Cienc Pecu. 2009 Mar; 22(1): 33-41 0120-0690 2256-2958 |
url |
http://hdl.handle.net/10495/10215 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Rev. Colomb. Cienc. Pecu. |
dc.rights.*.fl_str_mv |
Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
rights_invalid_str_mv |
Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) https://creativecommons.org/licenses/by-nc-sa/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Universidad de Antioquia, Facultad de Ciencias Agrarias |
dc.publisher.place.spa.fl_str_mv |
Medellín, Colombia |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
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andres.perez@udea.edu.co |
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spelling |
Ramírez Vásquez, Nicolás FernandoRuíz Buitrago, Jhon DidierRestrepo Betancur, Luis FernandoLópez Córdoba, Carlos Alberto2018-10-06T13:10:59Z2018-10-06T13:10:59Z2009Ramírez Vásquez NF, Ruíz Buitrago JD, Restrepo LF, López C. Kinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattle. Rev Colomb Cienc Pecu. 2009 Mar; 22(1): 33-410120-0690http://hdl.handle.net/10495/102152256-2958ABSTRACT: The mammary excretion of fenthion was determined in cross-bred (Bon x Holstein) and pure Holstein cows following a topical (pour-on) application of a commercial formulation. Two groups of five cows each received a single application at the recommended dosage of 10 mg/kg BW on the withers. Milk samples were collected twice a day, from the morning and afternoon milkings during a 5-day period and analyzed for fenthion and total fat contents. A bi-compartmental analysis was used to describe the pharmacokinetic parameters. Overall fenthion milk concentrations increased progressively to reach maximum peaks (Cmax) of 0.4 ppm and 0.2 ppm at about 33 hr post-treatment in cross-bred and pure Holstein cows, respectively. However, since total residues in milk were strongly correlated with total fat content, for any particular day the concentrations attained in the morning milking were lower than those for the afternoon collection. The elimination half-lives (T1/2) for the two cattle breeds were 52.5 and 59.3 hr for cross-bred and Holstein respectively as indicated by milk concentrations. Fenthion concentrations declined to the maximum residue limit of 0.05 ppm set by the OMS FAO at 8.0, and 6.61 days post application, in cross-bred and pure bred Holstein cows respectively. These results suggest that withdrawal time for milk from lactating dairy cows treated with topical fenthion, could be of 8 days approximately.RESUMEN: La excreción mamaria de fention se determinó en vacas productoras de leche cruzadas (Bon x Holstein) y Holstein puras, tras la aplicación tópica de una formulación comercial del compuesto. El producto se aplicó a dos grupos de cinco vacas por raza, a la dosis de 10 mg/Kg de peso vivo. Se colectaron muestras de leche dos veces diarias, en el ordeño de la mañana y de la tarde, por un período de cinco días y se midieron los niveles grasa y fention en leche. Se usó un análisis bicompartimental para describir los parámetros farmacocinéticos. Las concentraciones de fention en leche aumentaron progresivamente hasta alcanzar el pico máximo (Cmax) de 0.4 y 0.2 ppm a las 33 horas postratamiento en las vacas cruzadas y Holstein, respectivamente. Sin embargo, a pesar de que los residuos totales del fention se correlacionaron con el contenido de grasa, las concentraciones observadas en el ordeño de la mañana fueron menores que aquellas observadas en el ordeño de la tarde para las muestras de ese mismo día. Los tiempos medios de eliminación t1/2 fueron de 52,5 y 59.3 horas para el cruce y las vacas Holstein puras, respectivamente. Las vacas cruzadas y las vacas Holstein puras alcanzaron el nivel máximo de fention permitido por la OMS-FAO (0.05 ppm) a los 8.0 y a los 6.61 días después de la aplicación, respectivamente. Estos resultados sugieren que el tiempo de retiro de la leche de vacas en lactancia tratadas con fention vía dérmica podría ser 8 días aproximadamente.application/pdfengUniversidad de Antioquia, Facultad de Ciencias AgrariasMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Dairy cowsFenthion residuesInsecticidesWithdrawal timeKinetics of fenthion excretion in milk following a topical application in two breeds of dairy cattleCinética de la eliminación de fention en leche luego de una aplicación tópica en dos razas de ganado lecheroRev. Colomb. Cienc. Pecu.Revista Colombiana de Ciencias Pecuarias3341221LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/10215/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55ORIGINALRamirezVasquezNicolasFernando2009_KineticsFenthionExcretion.pdfRamirezVasquezNicolasFernando2009_KineticsFenthionExcretion.pdfArtículo de investigaciónapplication/pdf367915http://bibliotecadigital.udea.edu.co/bitstream/10495/10215/1/RamirezVasquezNicolasFernando2009_KineticsFenthionExcretion.pdfa08c76be930c689261081bc371d68bb1MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/10215/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/10215/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfLicenciaapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/10215/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD5410495/10215oai:bibliotecadigital.udea.edu.co:10495/102152021-05-21 20:30:58.417Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |