Proteínas relacionadas con el metabolismo del hierro corporal
ABSTRACT: Iron is an essential nutrient well studied for its role in human health, and much evidence exists regarding its metabolism, functions, interactions, and regulations. However, studies and analyses that have been done are often based on specific proteins and few integrate into a single text...
- Autores:
-
Corrales Agudelo, Vanessa
Parra Sosa, Beatriz Elena
Burgos Herrera, Luis Carlos
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11609
- Acceso en línea:
- http://hdl.handle.net/10495/11609
- Palabra clave:
- Hierro
Iron
Proteínas de unión al hierro
Iron binding proteins
Deficiencia de hierro
Iron deficiency
Homeostasis
Expresión génica
Gene expression
Oxidación-reducción
Oxidation-reduction
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
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Proteínas relacionadas con el metabolismo del hierro corporal |
| dc.title.alternative.spa.fl_str_mv |
Proteins associated with the metabolism of total body iron |
| title |
Proteínas relacionadas con el metabolismo del hierro corporal |
| spellingShingle |
Proteínas relacionadas con el metabolismo del hierro corporal Hierro Iron Proteínas de unión al hierro Iron binding proteins Deficiencia de hierro Iron deficiency Homeostasis Expresión génica Gene expression Oxidación-reducción Oxidation-reduction |
| title_short |
Proteínas relacionadas con el metabolismo del hierro corporal |
| title_full |
Proteínas relacionadas con el metabolismo del hierro corporal |
| title_fullStr |
Proteínas relacionadas con el metabolismo del hierro corporal |
| title_full_unstemmed |
Proteínas relacionadas con el metabolismo del hierro corporal |
| title_sort |
Proteínas relacionadas con el metabolismo del hierro corporal |
| dc.creator.fl_str_mv |
Corrales Agudelo, Vanessa Parra Sosa, Beatriz Elena Burgos Herrera, Luis Carlos |
| dc.contributor.author.none.fl_str_mv |
Corrales Agudelo, Vanessa Parra Sosa, Beatriz Elena Burgos Herrera, Luis Carlos |
| dc.subject.none.fl_str_mv |
Hierro Iron Proteínas de unión al hierro Iron binding proteins Deficiencia de hierro Iron deficiency Homeostasis Expresión génica Gene expression Oxidación-reducción Oxidation-reduction |
| topic |
Hierro Iron Proteínas de unión al hierro Iron binding proteins Deficiencia de hierro Iron deficiency Homeostasis Expresión génica Gene expression Oxidación-reducción Oxidation-reduction |
| description |
ABSTRACT: Iron is an essential nutrient well studied for its role in human health, and much evidence exists regarding its metabolism, functions, interactions, and regulations. However, studies and analyses that have been done are often based on specific proteins and few integrate into a single text the characteristics of multiple proteins related to total body iron metabolism. Objective: Explore in-depth the molecular, metabolic, and modulation aspects of proteins that participate in iron homeostasis and related interactions. Materials and methods: A literature review was completed using scientific databases in conjunction with a search for related scientific articles published between 2006 and 2016. Results: Homeostasis of total body iron stores is a complex process that is highly regulated by various molecules that participate in an integrated manner in iron metabolism. In recent years, new proteins have been discovered regarding the humoral and cellular control of iron, some of which are also involved in the transport of other nutrients. Additionally, these proteins involve participation from various organs, tissues, and systems. This review includes proteins responsible for facilitating biological utilization of the nutrient, as well as those that protect cells from toxicity of this mineral. |
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2016 |
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2016 |
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2019-08-05T21:31:36Z |
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2019-08-05T21:31:36Z |
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Artículo de revisión |
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Corrales-Agudelo V, Parra-Sosa BE, Burgos-Herrera LC. Proteínas relacionadas con el metabolismo del hierro corporal. Perspect. Nutr. Humana.. 2016;18:95-116. |
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0124-4108 |
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http://hdl.handle.net/10495/11609 |
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2248-454X |
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Corrales-Agudelo V, Parra-Sosa BE, Burgos-Herrera LC. Proteínas relacionadas con el metabolismo del hierro corporal. Perspect. Nutr. Humana.. 2016;18:95-116. 0124-4108 2248-454X |
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http://hdl.handle.net/10495/11609 |
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spa |
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spa |
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Perspect. Nutr. Humana. |
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Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
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Universidad de Antioquia, Escuela de Nutrición y Dietética |
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Alimentación y Nutrición Humana |
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Medellín, Colombia |
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Universidad de Antioquia |
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andres.perez@udea.edu.co |
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Corrales Agudelo, VanessaParra Sosa, Beatriz ElenaBurgos Herrera, Luis Carlos2019-08-05T21:31:36Z2019-08-05T21:31:36Z2016Corrales-Agudelo V, Parra-Sosa BE, Burgos-Herrera LC. Proteínas relacionadas con el metabolismo del hierro corporal. Perspect. Nutr. Humana.. 2016;18:95-116.0124-4108http://hdl.handle.net/10495/116092248-454XABSTRACT: Iron is an essential nutrient well studied for its role in human health, and much evidence exists regarding its metabolism, functions, interactions, and regulations. However, studies and analyses that have been done are often based on specific proteins and few integrate into a single text the characteristics of multiple proteins related to total body iron metabolism. Objective: Explore in-depth the molecular, metabolic, and modulation aspects of proteins that participate in iron homeostasis and related interactions. Materials and methods: A literature review was completed using scientific databases in conjunction with a search for related scientific articles published between 2006 and 2016. Results: Homeostasis of total body iron stores is a complex process that is highly regulated by various molecules that participate in an integrated manner in iron metabolism. In recent years, new proteins have been discovered regarding the humoral and cellular control of iron, some of which are also involved in the transport of other nutrients. Additionally, these proteins involve participation from various organs, tissues, and systems. This review includes proteins responsible for facilitating biological utilization of the nutrient, as well as those that protect cells from toxicity of this mineral.RESUMEN: El hierro es uno de los minerales más estudiados; existe amplia información en cuanto a su metabolismo, función, interacciones y regulación; sin embargo, los estudios y análisis realizados se basan en proteínas específicas y pocos integran, en un solo texto, las características de estas moléculas relacionadas con el metabolismo del hierro corporal. Objetivo: profundizar en los aspectos moleculares, metabólicos y de modulación de las proteínas que participan en la homeostasis del hierro y en sus interacciones. Materiales y métodos: se hizo una búsqueda sistemática de información en bases de datos científicas de artículos sobre el tema, publicados entre 2006 y 2016. Resultados: la homeostasis del hierro corporal, es un proceso complejo y altamente regulado por diferentes moléculas que participan de manera integrada en su metabolismo; en los últimos años han surgido nuevas proteínas, algunas de ellas participan en el transporte de otros nutrientes y se les ha encontrado relación con el control humoral y celular del hierro; además, involucran la participación de varios órganos, tejidos y sistemas. Esta revisión incluye proteínas encargadas de facilitar el aprovechamiento biológico del nutriente, así como aquellas que protegen a las células de toxicidad por exceso de este mineral.application/pdfspaUniversidad de Antioquia, Escuela de Nutrición y DietéticaAlimentación y Nutrición HumanaMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVArtículo de revisiónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/HierroIronProteínas de unión al hierroIron binding proteinsDeficiencia de hierroIron deficiencyHomeostasisExpresión génicaGene expressionOxidación-reducciónOxidation-reductionProteínas relacionadas con el metabolismo del hierro corporalProteins associated with the metabolism of total body ironPerspect. Nutr. Humana.Perspectivas en Nutrición Humana95116181CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/11609/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/11609/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfLicenciaapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/11609/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/11609/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55ORIGINALParraBeatriz_2016_ProteinasRelacionadasHierro.pdfParraBeatriz_2016_ProteinasRelacionadasHierro.pdfArtículo de revisiónapplication/pdf185012http://bibliotecadigital.udea.edu.co/bitstream/10495/11609/1/ParraBeatriz_2016_ProteinasRelacionadasHierro.pdfcb7354a320c962cf1ccfa93ef4227593MD5110495/11609oai:bibliotecadigital.udea.edu.co:10495/116092021-10-25 13:38:01.012Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |