Trombocitopenia Inducida por Rifampicina
ABSTRACT: Rifampicin-induced thrombocytopenia is a rare but potentially fatal immune phenomenon. We report the case of an immunocompromised patient with disseminated tuberculosis who developed rifampicin-induced thrombocytopenia 12 hours after starting anti-tuberculous therapy without previous drug...
- Autores:
-
Ramírez Quintero, Juan David
Molina Valencia, Juliana
Restrepo Ochoa, Alejandra
Arango Barrientos, Marcos
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12872
- Acceso en línea:
- http://hdl.handle.net/10495/12872
- Palabra clave:
- Trombocitopenia
Trombopenia
Tuberculosis
Rifampicina
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
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| dc.title.spa.fl_str_mv |
Trombocitopenia Inducida por Rifampicina |
| dc.title.alternative.spa.fl_str_mv |
Rifampicin-induced thrombocytopenia |
| title |
Trombocitopenia Inducida por Rifampicina |
| spellingShingle |
Trombocitopenia Inducida por Rifampicina Trombocitopenia Trombopenia Tuberculosis Rifampicina |
| title_short |
Trombocitopenia Inducida por Rifampicina |
| title_full |
Trombocitopenia Inducida por Rifampicina |
| title_fullStr |
Trombocitopenia Inducida por Rifampicina |
| title_full_unstemmed |
Trombocitopenia Inducida por Rifampicina |
| title_sort |
Trombocitopenia Inducida por Rifampicina |
| dc.creator.fl_str_mv |
Ramírez Quintero, Juan David Molina Valencia, Juliana Restrepo Ochoa, Alejandra Arango Barrientos, Marcos |
| dc.contributor.author.none.fl_str_mv |
Ramírez Quintero, Juan David Molina Valencia, Juliana Restrepo Ochoa, Alejandra Arango Barrientos, Marcos |
| dc.subject.none.fl_str_mv |
Trombocitopenia Trombopenia Tuberculosis Rifampicina |
| topic |
Trombocitopenia Trombopenia Tuberculosis Rifampicina |
| description |
ABSTRACT: Rifampicin-induced thrombocytopenia is a rare but potentially fatal immune phenomenon. We report the case of an immunocompromised patient with disseminated tuberculosis who developed rifampicin-induced thrombocytopenia 12 hours after starting anti-tuberculous therapy without previous drug sensitization. The cause-effect relationship was confirmed when thrombocytopenia resolved with rifampicin suspension but later reappeared upon drug re-exposure. |
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2018 |
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2018 |
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2020-01-06T16:26:07Z |
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2020-01-06T16:26:07Z |
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Molina-Valencia J, Restrepo-Ochoa A, Arango-Barrientos M, Ramírez-Quintero JD. Trombocitopenia inducida por rifampicina. Iatreia. 2018 Ene-Mar;31(1):103-107. DOI 10.17533/udea.iatreia.v31n1a11 |
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0121-0793 |
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http://hdl.handle.net/10495/12872 |
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10.17533/udea.iatreia.v31n1a11 |
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2011-7965 |
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Molina-Valencia J, Restrepo-Ochoa A, Arango-Barrientos M, Ramírez-Quintero JD. Trombocitopenia inducida por rifampicina. Iatreia. 2018 Ene-Mar;31(1):103-107. DOI 10.17533/udea.iatreia.v31n1a11 0121-0793 10.17533/udea.iatreia.v31n1a11 2011-7965 |
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spa |
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Iatreia |
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Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
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info:eu-repo/semantics/openAccess |
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Universidad de Antioquia, Facultad de Medicina |
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Medellín, Colombia |
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Universidad de Antioquia |
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Ramírez Quintero, Juan DavidMolina Valencia, JulianaRestrepo Ochoa, AlejandraArango Barrientos, Marcos2020-01-06T16:26:07Z2020-01-06T16:26:07Z2018Molina-Valencia J, Restrepo-Ochoa A, Arango-Barrientos M, Ramírez-Quintero JD. Trombocitopenia inducida por rifampicina. Iatreia. 2018 Ene-Mar;31(1):103-107. DOI 10.17533/udea.iatreia.v31n1a110121-0793http://hdl.handle.net/10495/1287210.17533/udea.iatreia.v31n1a112011-7965ABSTRACT: Rifampicin-induced thrombocytopenia is a rare but potentially fatal immune phenomenon. We report the case of an immunocompromised patient with disseminated tuberculosis who developed rifampicin-induced thrombocytopenia 12 hours after starting anti-tuberculous therapy without previous drug sensitization. The cause-effect relationship was confirmed when thrombocytopenia resolved with rifampicin suspension but later reappeared upon drug re-exposure.RESUMEN: La trombocitopenia inducida por rifampicina es un fenómeno de origen inmune cuya presentación es inusual pero potencialmente fatal. Se presenta el caso de un paciente inmunocomprometido y con tuberculosis diseminada quien desarrolló trombocitopenia inducida por rifampicina en las primeras 12 horas tras inicio de la terapia antituberculosa sin que mediara sensibilización previa al medicamento. Se confirmó la relación de causa-efecto al resolverse la trombocitopenia con la suspensión de la rifampicina y al reaparecer con la re-exposición al fármaco.4application/pdfspaUniversidad de Antioquia, Facultad de MedicinaMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTCASOArtículo de revistahttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/TrombocitopeniaTrombopeniaTuberculosisRifampicinaTrombocitopenia Inducida por RifampicinaRifampicin-induced thrombocytopeniaIatreiaIatreia103107312ORIGINALRamirezJuan_2018_TrombocitopeniaInducidaRifampicina.pdfRamirezJuan_2018_TrombocitopeniaInducidaRifampicina.pdfArtículo de revistaapplication/pdf117071http://bibliotecadigital.udea.edu.co/bitstream/10495/12872/6/RamirezJuan_2018_TrombocitopeniaInducidaRifampicina.pdf22cdcc3793427d2d850906fd44c893fcMD56CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/12872/7/license_url4afdbb8c545fd630ea7db775da747b2fMD57license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/12872/8/license_textd41d8cd98f00b204e9800998ecf8427eMD58license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/12872/9/license_rdfd41d8cd98f00b204e9800998ecf8427eMD59LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/12872/10/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51010495/12872oai:bibliotecadigital.udea.edu.co:10495/128722021-03-23 09:48:17.116Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |