Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L
ABSTARCT: Jatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are few scientific reports validating its activity in this area. In this work and through a bioguided assay, a crude extract stimulated glucose uptake in C2C12 myo...
- Autores:
-
Granados Cuello, Sergio Daniel
Balcázar, Norman
Guillen, Alis Jeanet
Echeverri, Fernando
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11486
- Acceso en línea:
- http://hdl.handle.net/10495/11486
- Palabra clave:
- Jatropha gossypifolia L
Flavanone
Flavone
Glucose regulation
Myotubes
Mice molecules
- Rights
- openAccess
- License
- Atribución 2.5
| id |
UDEA2_4f0e4ee16c30a63b0119d37b37ebe76a |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/11486 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L |
| title |
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L |
| spellingShingle |
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L Jatropha gossypifolia L Flavanone Flavone Glucose regulation Myotubes Mice molecules |
| title_short |
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L |
| title_full |
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L |
| title_fullStr |
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L |
| title_full_unstemmed |
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L |
| title_sort |
Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L |
| dc.creator.fl_str_mv |
Granados Cuello, Sergio Daniel Balcázar, Norman Guillen, Alis Jeanet Echeverri, Fernando |
| dc.contributor.author.none.fl_str_mv |
Granados Cuello, Sergio Daniel Balcázar, Norman Guillen, Alis Jeanet Echeverri, Fernando |
| dc.subject.none.fl_str_mv |
Jatropha gossypifolia L Flavanone Flavone Glucose regulation Myotubes Mice molecules |
| topic |
Jatropha gossypifolia L Flavanone Flavone Glucose regulation Myotubes Mice molecules |
| description |
ABSTARCT: Jatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are few scientific reports validating its activity in this area. In this work and through a bioguided assay, a crude extract stimulated glucose uptake in C2C12 myotubes up to 30%, thereby reducing insulin resistance induced by fatty acids compared to the basal control. A chromatographic fraction applied intraperitoneally (IP) in mice reduced glucose by 42% in a mouse model of T2DM, after administration of 10 doses during 20 days. A flavanone was purified from this active fraction and its structure was assigned by 1H- and 13C-NMR (1D and 2D) and MS. This compound retains the previously reported activity, stimulating in vitro the glucose uptake in a concentration-dependent manner. This study indicates that Jatropha gossypifolia L. extracts enhance glucose uptake in cultured myotubes and adipocytes and also improving glucose tolerance in an in vivo model. Keywords: Jatropha gossypifolia L, Flavanone, Flavone, Glucose regulation, Myotubes, Mice |
| publishDate |
2015 |
| dc.date.issued.none.fl_str_mv |
2015 |
| dc.date.accessioned.none.fl_str_mv |
2019-07-23T14:05:49Z |
| dc.date.available.none.fl_str_mv |
2019-07-23T14:05:49Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.local.spa.fl_str_mv |
Artículo de investigación |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Granados S, Balcázar N, Guillén A, Echeverri F. Evaluation of the hypoglycemic effects of flavonoids and extracts from Jatropha gossypifolia L. Molecules. 2015 Apr 9;20(4):6181-93 |
| dc.identifier.issn.none.fl_str_mv |
1420-3049 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/11486 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/molecules20046181 |
| identifier_str_mv |
Granados S, Balcázar N, Guillén A, Echeverri F. Evaluation of the hypoglycemic effects of flavonoids and extracts from Jatropha gossypifolia L. Molecules. 2015 Apr 9;20(4):6181-93 1420-3049 10.3390/molecules20046181 |
| url |
http://hdl.handle.net/10495/11486 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Molecules |
| dc.rights.*.fl_str_mv |
Atribución 2.5 |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ |
| dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| rights_invalid_str_mv |
Atribución 2.5 http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
12 |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
MDPI AG |
| dc.publisher.group.spa.fl_str_mv |
Quimica Organica de Productos Naturales |
| dc.publisher.place.spa.fl_str_mv |
Suiza |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/1/GranadosSergio_2015_HypoplycemicEffectsFlavonoids.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/2/license_url http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/3/license_text http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/4/license_rdf http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/5/license.txt |
| bitstream.checksum.fl_str_mv |
902724b65fced2eacf626e4129a0fad9 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e 8a4605be74aa9ea9d79846c1fba20a33 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
| repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
| _version_ |
1812173221733072896 |
| spelling |
Granados Cuello, Sergio DanielBalcázar, NormanGuillen, Alis JeanetEcheverri, Fernando2019-07-23T14:05:49Z2019-07-23T14:05:49Z2015Granados S, Balcázar N, Guillén A, Echeverri F. Evaluation of the hypoglycemic effects of flavonoids and extracts from Jatropha gossypifolia L. Molecules. 2015 Apr 9;20(4):6181-931420-3049http://hdl.handle.net/10495/1148610.3390/molecules20046181ABSTARCT: Jatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are few scientific reports validating its activity in this area. In this work and through a bioguided assay, a crude extract stimulated glucose uptake in C2C12 myotubes up to 30%, thereby reducing insulin resistance induced by fatty acids compared to the basal control. A chromatographic fraction applied intraperitoneally (IP) in mice reduced glucose by 42% in a mouse model of T2DM, after administration of 10 doses during 20 days. A flavanone was purified from this active fraction and its structure was assigned by 1H- and 13C-NMR (1D and 2D) and MS. This compound retains the previously reported activity, stimulating in vitro the glucose uptake in a concentration-dependent manner. This study indicates that Jatropha gossypifolia L. extracts enhance glucose uptake in cultured myotubes and adipocytes and also improving glucose tolerance in an in vivo model. Keywords: Jatropha gossypifolia L, Flavanone, Flavone, Glucose regulation, Myotubes, Mice12application/pdfengMDPI AGQuimica Organica de Productos NaturalesSuizainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución 2.5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Jatropha gossypifolia LFlavanoneFlavoneGlucose regulationMyotubesMice moleculesEvaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia LMoleculesMolecules61816193204ORIGINALGranadosSergio_2015_HypoplycemicEffectsFlavonoids.pdfGranadosSergio_2015_HypoplycemicEffectsFlavonoids.pdfGranadosSergio_2015_HypoplycemicEffectsFlavonoidsapplication/pdf1920419http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/1/GranadosSergio_2015_HypoplycemicEffectsFlavonoids.pdf902724b65fced2eacf626e4129a0fad9MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/11486/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/11486oai:bibliotecadigital.udea.edu.co:10495/114862021-03-24 20:46:21.105Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |