Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?

ABSTRACT: Background: According to WHO, CDC, IDSA and ATS guidelines, patients with pulmonary tuberculosis (Tb) can be considered as non infectious when: 1) they are receiving multiple drugs for 2 to 3 weeks; 2) there is an improvement in clinical condition; 3) the likelihood of MDR-Tb is very small...

Full description

Autores:
Vélez Giraldo, Lázaro Agustín
López López, Lucelly
Rueda Vallejo, Zulma Vanessa
Giraldo, Margarita Rosa
Marín Pineda, Diana Marcela
Zapata, Elsa
Mejía Mesa, Gloria Isabel
Robledo, Jaime
Arbeláez Montoya, María Patricia
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/32010
Acceso en línea:
https://hdl.handle.net/10495/32010
Palabra clave:
Tuberculosis Pulmonar
Tuberculosis, Pulmonary
Aislamiento de Pacientes
Patient Isolation
Prisioneros
Prisoners
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_49934d6dedea782776ed14b7e758f3e9
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/32010
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?
title Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?
spellingShingle Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?
Tuberculosis Pulmonar
Tuberculosis, Pulmonary
Aislamiento de Pacientes
Patient Isolation
Prisioneros
Prisoners
title_short Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?
title_full Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?
title_fullStr Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?
title_full_unstemmed Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?
title_sort Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?
dc.creator.fl_str_mv Vélez Giraldo, Lázaro Agustín
López López, Lucelly
Rueda Vallejo, Zulma Vanessa
Giraldo, Margarita Rosa
Marín Pineda, Diana Marcela
Zapata, Elsa
Mejía Mesa, Gloria Isabel
Robledo, Jaime
Arbeláez Montoya, María Patricia
dc.contributor.author.none.fl_str_mv Vélez Giraldo, Lázaro Agustín
López López, Lucelly
Rueda Vallejo, Zulma Vanessa
Giraldo, Margarita Rosa
Marín Pineda, Diana Marcela
Zapata, Elsa
Mejía Mesa, Gloria Isabel
Robledo, Jaime
Arbeláez Montoya, María Patricia
dc.subject.decs.none.fl_str_mv Tuberculosis Pulmonar
Tuberculosis, Pulmonary
Aislamiento de Pacientes
Patient Isolation
Prisioneros
Prisoners
topic Tuberculosis Pulmonar
Tuberculosis, Pulmonary
Aislamiento de Pacientes
Patient Isolation
Prisioneros
Prisoners
description ABSTRACT: Background: According to WHO, CDC, IDSA and ATS guidelines, patients with pulmonary tuberculosis (Tb) can be considered as non infectious when: 1) they are receiving multiple drugs for 2 to 3 weeks; 2) there is an improvement in clinical condition; 3) the likelihood of MDR-Tb is very small. Objective: To determine the time for sputum reversion since the start of anti-Tb treatment in prisoners from four jails in Medellin and Bucaramanga, Colombia between May 2010 to April 2011. Methods: Prospective cohort study. All prisoners diagnosed with Tb by sputum smear or culture were followed for two years: monthly for the first six months after the start of treatment, bimonthly the next six months, and quarterly the second year. During follow-up, we took two spontaneous and one induced sputum samples for auramine-rodhamine stain, and cultures in thin layer agar, Löwestein-Jensen and MGIT for the both first samples. We did time to event analysis. Results: We could follow 45 of 47 positive patients (one was transferred to another jail and one Tb-related death). The median for sputum smear reversion was 33 days (IQR: 31-60), and for culture was 55 days (IQR: 32-68). 90% of the patients had sputum smear and culture negative at 102 days. The time for sputum to become negative by culture had a positive correlation with the sputum grade at the moment of diagnosis: negative smear with positive culture= median 31.5 days, smear with 1+ = 58.5 days, smear 2+ = 62 days, and smear 3+ = 65 days (p value = 0.007). Conclusion: After starting treatment the reversion of cultures took two or more months in ≥50% cases. That is forcing us to rethink the recommendations about the isolation of patients with pulmonary Tb in prisons, and suggests the need to use mycobacterial cultures on sputum to follow-up those patients.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2022-11-13T18:06:24Z
dc.date.available.none.fl_str_mv 2022-11-13T18:06:24Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/CJournalArticle
dc.type.local.spa.fl_str_mv Artículo de revista
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 1201-9712
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/32010
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2012.05.956
identifier_str_mv 1201-9712
10.1016/j.ijid.2012.05.956
url https://hdl.handle.net/10495/32010
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Int. J. Infect. Dis.
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rights.accessrights.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.extent.spa.fl_str_mv 1
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
International Society for Infectious Diseases
dc.publisher.group.spa.fl_str_mv GRIPE: Grupo Investigador de Problemas en Enfermedades Infecciosas
dc.publisher.place.spa.fl_str_mv Hamilton, Canadá
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/32010/1/VelezLazaro_2012_IsolationReevaluatedTuberculosis.pdf
https://bibliotecadigital.udea.edu.co/bitstream/10495/32010/2/license_rdf
https://bibliotecadigital.udea.edu.co/bitstream/10495/32010/3/license.txt
bitstream.checksum.fl_str_mv 7504a3b6faac6e0a6ea6f6166fbbad3a
b88b088d9957e670ce3b3fbe2eedbc13
8a4605be74aa9ea9d79846c1fba20a33
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
repository.mail.fl_str_mv andres.perez@udea.edu.co
_version_ 1812173118233378816
spelling Vélez Giraldo, Lázaro AgustínLópez López, LucellyRueda Vallejo, Zulma VanessaGiraldo, Margarita RosaMarín Pineda, Diana MarcelaZapata, ElsaMejía Mesa, Gloria IsabelRobledo, JaimeArbeláez Montoya, María Patricia2022-11-13T18:06:24Z2022-11-13T18:06:24Z20121201-9712https://hdl.handle.net/10495/3201010.1016/j.ijid.2012.05.956ABSTRACT: Background: According to WHO, CDC, IDSA and ATS guidelines, patients with pulmonary tuberculosis (Tb) can be considered as non infectious when: 1) they are receiving multiple drugs for 2 to 3 weeks; 2) there is an improvement in clinical condition; 3) the likelihood of MDR-Tb is very small. Objective: To determine the time for sputum reversion since the start of anti-Tb treatment in prisoners from four jails in Medellin and Bucaramanga, Colombia between May 2010 to April 2011. Methods: Prospective cohort study. All prisoners diagnosed with Tb by sputum smear or culture were followed for two years: monthly for the first six months after the start of treatment, bimonthly the next six months, and quarterly the second year. During follow-up, we took two spontaneous and one induced sputum samples for auramine-rodhamine stain, and cultures in thin layer agar, Löwestein-Jensen and MGIT for the both first samples. We did time to event analysis. Results: We could follow 45 of 47 positive patients (one was transferred to another jail and one Tb-related death). The median for sputum smear reversion was 33 days (IQR: 31-60), and for culture was 55 days (IQR: 32-68). 90% of the patients had sputum smear and culture negative at 102 days. The time for sputum to become negative by culture had a positive correlation with the sputum grade at the moment of diagnosis: negative smear with positive culture= median 31.5 days, smear with 1+ = 58.5 days, smear 2+ = 62 days, and smear 3+ = 65 days (p value = 0.007). Conclusion: After starting treatment the reversion of cultures took two or more months in ≥50% cases. That is forcing us to rethink the recommendations about the isolation of patients with pulmonary Tb in prisons, and suggests the need to use mycobacterial cultures on sputum to follow-up those patients.COL00057441application/pdfengElsevierInternational Society for Infectious DiseasesGRIPE: Grupo Investigador de Problemas en Enfermedades InfecciosasHamilton, Canadáinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/redcol/resource_type/CJournalArticleArtículo de revistahttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Does the time of isolation need to be re-evaluated in prisoners with tuberculosis?Tuberculosis PulmonarTuberculosis, PulmonaryAislamiento de PacientesPatient IsolationPrisionerosPrisonersInt. J. Infect. Dis.International Journal of Infectious Diseasese286e28616ORIGINALVelezLazaro_2012_IsolationReevaluatedTuberculosis.pdfVelezLazaro_2012_IsolationReevaluatedTuberculosis.pdfArtículo de revistaapplication/pdf86659https://bibliotecadigital.udea.edu.co/bitstream/10495/32010/1/VelezLazaro_2012_IsolationReevaluatedTuberculosis.pdf7504a3b6faac6e0a6ea6f6166fbbad3aMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/32010/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/32010/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/32010oai:bibliotecadigital.udea.edu.co:10495/320102022-11-13 13:06:24.548Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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