Evaluación de citotoxicidad de nuevos análogos de estirilquinolinas en células leucemoides Jurkat

ABSTRACT: Some of the most commonly used and effective drugs used in antileukemic treatments posses principal chemical structures with quinoline rings and/or styrene groups, which might suggest that analogous compounds may serve as potential new antiproliferative agents. Recently, one of our laboratories synthesised six new styrylquinoline analogues as candidates for having antiproliferative and/or anti-cancer effects. thus, using the Mtt assay we evaluated the cytotoxicity of these six compounds in the leukemoid cell line Jurkat. the results showed an absence of cytotoxic effects at the concentrations and times assayed. In addition, when the treatments were applied in the presence of S9 microsomal fraction, cell viability was not altered in this leukemoid in vitro model. these results open the possibility of evaluating these styrylquinolines in other cell lines or diseases models with the goal of examining promising biomedical effects. Key words: Jurkat, leukemia, MTT, S9, styrylquinoline, viability.

• Autores: Soto López, Andrés Felipe; Meneses Bermúdez, Juan Pablo; Camargo Guerrero, Mauricio; Sáez Vega, Jairo Antonio
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2011
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: spa
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/11079
• Acceso en línea: http://hdl.handle.net/10495/11079
• Palabra clave: Jurkat; Jurkat; Leucemia; Leukemia; Estirilquinolina; Styrylquinoline
• Rights: openAccess
• License: Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)