Effect of serotonin modulating pharmacotherapies on body mass index and dysglycaemia among children and adolescents: a systematic review and network meta-analysis protocol
ABSTRACT: Introduction: Serotonin-modulating medications are commonly prescribed for mental health issues. Currently, there is limited consensus on weight gain and dysglycaemia development among children using these medications. The objective of this study is to review and synthesize all the availab...
- Autores:
-
Flórez Gómez, Iván Darío
De Long, Nicole E.
Al Khalifah, Reem A.
Mbuagbaw, Lawrence
Morrison, Katherine M.
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/32150
- Acceso en línea:
- https://hdl.handle.net/10495/32150
- Palabra clave:
- Glucemia
Blood Glucose
Índice de Masa Corporal
Body Mass Index
Peso Corporal - efectos de los fármacos
Body Weight - drug effects
Metaanálisis en Red
Network Meta-Analysis
Evaluación de Resultado en la Atención de Salud
Outcome Assessment, Health Care
Ensayos Clínicos Controlados Aleatorios como Asunto
Randomized Controlled Trials as Topic
Antagonistas de la Serotonina
Serotonin Antagonists
Inhibidores de la Captación de Serotonina
Serotonin Uptake Inhibitors
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/2.5/co/
Summary: | ABSTRACT: Introduction: Serotonin-modulating medications are commonly prescribed for mental health issues. Currently, there is limited consensus on weight gain and dysglycaemia development among children using these medications. The objective of this study is to review and synthesize all the available evidence on serotonin-modulating medications and their effects on body mass index (BMI), weight and glycaemic control. Methods and analysis: We will conduct a systematic review of all randomized controlled trials evaluating the use of serotonin-modulating medications in the treatment of children 2–17 years with mental health conditions. The outcome measures are BMI, weight and dysglycaemia. We will perform literature searches through Ovid Medline, Ovid Embase, PsycINFO and grey literature resources. Two reviewers from the team will independently screen titles and abstracts, assess the eligibility of full-text trials, extract information from eligible trials and assess the risk of bias and quality of the evidence. Results of this review will be summarized narratively and quantitatively as appropriate. We will perform a multiple treatment comparison using network meta-analysis to estimate the pooled direct, indirect and network estimate for all serotonin-modulating medications on outcomes if adequate data are available. Ethics and dissemination: Serotonin-modulating medications are widely prescribed for children with mental health diseases and are also used off-label. This network meta-analysis will be the first to assess serotonin modulating antidepressants and their effects on weight and glycaemic control. We anticipate that our results will help physicians and patients make more informed choices while considering the side effect profile. We will disseminate the results of the systematic review and network meta-analysis through peer-reviewed journals. |
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