A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study

ABSTRACT: Objective: To evaluate and compare the particle and tableting properties of a new sorbitol (SOR) and anhydrous calcium diphosphate (ACD)composite with common excipients used for the preparation of tablets by direct compression such as polyvinylpyrrolidone (Ludipress®), lactose (Cellactose...

Full description

Autores:
Echeverrri Pineda, Edward
Rojas Camargo, Jhon
Bedoya, Mauricio
Tipo de recurso:
Article of investigation
Fecha de publicación:
2016
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/32682
Acceso en línea:
https://hdl.handle.net/10495/32682
https://innovareacademics.in/journals/index.php/ijpps/article/view/8845/
Palabra clave:
Sorbitol
Pirofosfato de Calcio
Calcium Pyrophosphate
Aglomeración
Agglomeration
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
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oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/32682
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study
title A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study
spellingShingle A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study
Sorbitol
Pirofosfato de Calcio
Calcium Pyrophosphate
Aglomeración
Agglomeration
title_short A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study
title_full A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study
title_fullStr A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study
title_full_unstemmed A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study
title_sort A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study
dc.creator.fl_str_mv Echeverrri Pineda, Edward
Rojas Camargo, Jhon
Bedoya, Mauricio
dc.contributor.author.none.fl_str_mv Echeverrri Pineda, Edward
Rojas Camargo, Jhon
Bedoya, Mauricio
dc.subject.decs.none.fl_str_mv Sorbitol
Pirofosfato de Calcio
Calcium Pyrophosphate
topic Sorbitol
Pirofosfato de Calcio
Calcium Pyrophosphate
Aglomeración
Agglomeration
dc.subject.lemb.none.fl_str_mv Aglomeración
Agglomeration
description ABSTRACT: Objective: To evaluate and compare the particle and tableting properties of a new sorbitol (SOR) and anhydrous calcium diphosphate (ACD)composite with common excipients used for the preparation of tablets by direct compression such as polyvinylpyrrolidone (Ludipress®), lactose (Cellactose 80®) and microcrystalline cellulose (Prosolv SMCC 90®). Methods: All materials were tested for lubricant sensitivity, ejection force, and elastic recovery, dilution potential and reworking ability. Further, compressibility and compactibility were determined using the Heckel and Leuenberger models, respectively.Results: This new excipient offered more benefits in terms of functionality than commercial direct compressive co-processed excipients andshowed better compressibility than other commercial excipients and its compactibility was ranked third after SOR and Prosolv SMCC 90®. However, this composite material was more susceptible to reprocessing than commercial products. Further, it showed a low lubricant sensitivity due to a combination of a plastic and brittle behavior. Moreover, the loading capacity of poorly compressible materials such as gemfibrozil was comparable to that of commercial direct compression excipients. It also showed the fastest in-vitro dissolution of gemfibrozil, whereas commercial products failed to fulfill the US pharmacopoeial requirements. Conclusion: This new composite material showed potential for use as a direct compression excipient.
publishDate 2016
dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2022-12-09T23:27:18Z
dc.date.available.none.fl_str_mv 2022-12-09T23:27:18Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.local.spa.fl_str_mv Artículo de investigación
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dc.identifier.citation.spa.fl_str_mv Echeverri E, Rojas J, Bedoya M. A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study. Int J Pharm Pharm Sci [Internet]. 2016 Apr. 1 [cited 2022 Dec. 10];8(4):43-9. Available from: https://innovareacademics.in/journals/index.php/ijpps/article/view/8845
dc.identifier.issn.none.fl_str_mv 0975-1491
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/32682
dc.identifier.eissn.none.fl_str_mv 2656-0097
dc.identifier.url.spa.fl_str_mv https://innovareacademics.in/journals/index.php/ijpps/article/view/8845/
identifier_str_mv Echeverri E, Rojas J, Bedoya M. A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study. Int J Pharm Pharm Sci [Internet]. 2016 Apr. 1 [cited 2022 Dec. 10];8(4):43-9. Available from: https://innovareacademics.in/journals/index.php/ijpps/article/view/8845
0975-1491
2656-0097
url https://hdl.handle.net/10495/32682
https://innovareacademics.in/journals/index.php/ijpps/article/view/8845/
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Int. J. Pharm. Pharm. Sci.
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.format.extent.spa.fl_str_mv 7
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dc.publisher.spa.fl_str_mv IJPPS
dc.publisher.group.spa.fl_str_mv Diseño y Formulación de Medicamentos Cosméticos y Afines
dc.publisher.place.spa.fl_str_mv Bhopal, India
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/32682/1/EcheverriEdwuard_2016_ANewExhancedSorbitol.pdf
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spelling Echeverrri Pineda, EdwardRojas Camargo, JhonBedoya, Mauricio2022-12-09T23:27:18Z2022-12-09T23:27:18Z2016Echeverri E, Rojas J, Bedoya M. A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative Study. Int J Pharm Pharm Sci [Internet]. 2016 Apr. 1 [cited 2022 Dec. 10];8(4):43-9. Available from: https://innovareacademics.in/journals/index.php/ijpps/article/view/88450975-1491https://hdl.handle.net/10495/326822656-0097https://innovareacademics.in/journals/index.php/ijpps/article/view/8845/ABSTRACT: Objective: To evaluate and compare the particle and tableting properties of a new sorbitol (SOR) and anhydrous calcium diphosphate (ACD)composite with common excipients used for the preparation of tablets by direct compression such as polyvinylpyrrolidone (Ludipress®), lactose (Cellactose 80®) and microcrystalline cellulose (Prosolv SMCC 90®). Methods: All materials were tested for lubricant sensitivity, ejection force, and elastic recovery, dilution potential and reworking ability. Further, compressibility and compactibility were determined using the Heckel and Leuenberger models, respectively.Results: This new excipient offered more benefits in terms of functionality than commercial direct compressive co-processed excipients andshowed better compressibility than other commercial excipients and its compactibility was ranked third after SOR and Prosolv SMCC 90®. However, this composite material was more susceptible to reprocessing than commercial products. Further, it showed a low lubricant sensitivity due to a combination of a plastic and brittle behavior. Moreover, the loading capacity of poorly compressible materials such as gemfibrozil was comparable to that of commercial direct compression excipients. It also showed the fastest in-vitro dissolution of gemfibrozil, whereas commercial products failed to fulfill the US pharmacopoeial requirements. Conclusion: This new composite material showed potential for use as a direct compression excipient.COL00036237application/pdfengIJPPSDiseño y Formulación de Medicamentos Cosméticos y AfinesBhopal, Indiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/A New Enhanced Sorbitol: Calcium Diphosphate Composite as A Direct Compression Excipient: A Comparative StudySorbitolPirofosfato de CalcioCalcium PyrophosphateAglomeraciónAgglomerationInt. J. Pharm. Pharm. Sci.International Journal of Pharmacy and Pharmaceutical Sciences434984ORIGINALEcheverriEdwuard_2016_ANewExhancedSorbitol.pdfEcheverriEdwuard_2016_ANewExhancedSorbitol.pdfArtículo de investigaciónapplication/pdf943893https://bibliotecadigital.udea.edu.co/bitstream/10495/32682/1/EcheverriEdwuard_2016_ANewExhancedSorbitol.pdfca497570989ba0f1fee984d6115b0926MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927https://bibliotecadigital.udea.edu.co/bitstream/10495/32682/2/license_rdf1646d1f6b96dbbbc38035efc9239ac9cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/32682/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/32682oai:bibliotecadigital.udea.edu.co:10495/326822022-12-09 18:27:18.658Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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