Mucormycosis (Zygomycosis) in a heart-Kidney trasplant recipient : recovery after posaconazole therapy

ABSTRACT: We describe the case of a diabetic patient who developed a severe invasive fungal infection due to Rhizopus species postoperatively after a dual heart/kidney transplantation with subsequent intensive immunosuppressive therapy. No improvement was noted with amphotericin B (deoxycholate) therapy, but salvage treatment with the new azole antifungal posaconazole (200 mg orally 4 times daily) resulted in dramatic clinical improvement as early as 1 week after the initiation of therapy that continued through 23 weeks of treatment, with marked clinical, mycological, and radiological improvements and no adverse events.

• Autores: Tobón Orozco, Ángela María; Arango Arteaga, Myrtha; Fernández, Darío; Restrepo Moreno, Ángela
• Tipo de recurso: Article of journal
• Fecha de publicación: 2003
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/24085
• Acceso en línea: http://hdl.handle.net/10495/24085
• Palabra clave: Diabetes mellitus; Trasplante de Riñón; Kidney Transplantation; Zigomicosis; Zygomycosis; Anfotericina B; Amphotericin B; Mucormicosis; Mucormycosis; Rhizopus; Ácido Desoxicólico; Deoxycholic Acid; Receptores de Trasplantes; Transplant Recipients; Riñón; Kidney; Corazón; Heart; Inmunosupresión; Inmunosuppression
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/