Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave
ABSTRACT:Glycoproteins attached to cell membrane of syncytiotrophoblast are in close contact with maternal blood, thus these molecules could participate in cell-to-cell communication and biological functions involving ligand-receptors in the maternal-fetal interphase. The attached glycans are involv...
- Autores:
-
Gómez Gutiérrez, Alejandra María
Parra Sosa, Beatriz Elena
Bueno Sánchez, Julio César
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/21966
- Acceso en línea:
- http://hdl.handle.net/10495/21966
- Palabra clave:
- Glycosylation
Glicosilación
Anemia
Anaemia
Early-onset severe preeclampsia
Transferrin-receptor 1
http://aims.fao.org/aos/agrovoc/c_380
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/2.5/co/
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| dc.title.spa.fl_str_mv |
Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave |
| dc.title.alternative.spa.fl_str_mv |
Glycans in villus trophoblast in iron defi ciency anemia and early-onset severe preeclampsia |
| title |
Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave |
| spellingShingle |
Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave Glycosylation Glicosilación Anemia Anaemia Early-onset severe preeclampsia Transferrin-receptor 1 http://aims.fao.org/aos/agrovoc/c_380 |
| title_short |
Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave |
| title_full |
Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave |
| title_fullStr |
Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave |
| title_full_unstemmed |
Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave |
| title_sort |
Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave |
| dc.creator.fl_str_mv |
Gómez Gutiérrez, Alejandra María Parra Sosa, Beatriz Elena Bueno Sánchez, Julio César |
| dc.contributor.author.none.fl_str_mv |
Gómez Gutiérrez, Alejandra María Parra Sosa, Beatriz Elena Bueno Sánchez, Julio César |
| dc.subject.decs.none.fl_str_mv |
Glycosylation Glicosilación |
| topic |
Glycosylation Glicosilación Anemia Anaemia Early-onset severe preeclampsia Transferrin-receptor 1 http://aims.fao.org/aos/agrovoc/c_380 |
| dc.subject.agrovoc.none.fl_str_mv |
Anemia Anaemia |
| dc.subject.proposal.spa.fl_str_mv |
Early-onset severe preeclampsia Transferrin-receptor 1 |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_380 |
| description |
ABSTRACT:Glycoproteins attached to cell membrane of syncytiotrophoblast are in close contact with maternal blood, thus these molecules could participate in cell-to-cell communication and biological functions involving ligand-receptors in the maternal-fetal interphase. The attached glycans are involved in the stability, folding and exportation of the protein towards the cell membrane. The objective of this study was to characterize the glycan profi le of third trimester placental villi obtained from pregnant women with early-onset severe preeclampsia and gestational anemia compared with normal pregnant women. Protein extracts from placental villi were used in lectin blot assays. -2,3 N- and O-linked sialic acid was over-expressed in villous of severe preeclamptic placentas measured by MAA lectin staining. High mannose glycans and Gal-GlcNAc patterns were also increased in severe preeclampsia compared with the other groups. These findings can explain changes in the cell membrane expression of glycoproteins. |
| publishDate |
2015 |
| dc.date.issued.none.fl_str_mv |
2015 |
| dc.date.accessioned.none.fl_str_mv |
2021-08-30T12:01:07Z |
| dc.date.available.none.fl_str_mv |
2021-08-30T12:01:07Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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0716-1549 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/21966 |
| dc.identifier.doi.none.fl_str_mv |
10.4067/S0717-75182015000200002. |
| dc.identifier.eissn.none.fl_str_mv |
0717-7518 |
| identifier_str_mv |
0716-1549 10.4067/S0717-75182015000200002. 0717-7518 |
| url |
http://hdl.handle.net/10495/21966 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Rev. Chil. Nutr. |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc/2.5/co/ |
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openAccess |
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http://creativecommons.org/licenses/by-nc/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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| dc.publisher.spa.fl_str_mv |
Sociedad Chilena de Nutrición, Bromatología y Toxicología |
| dc.publisher.group.spa.fl_str_mv |
Alimentación y Nutrición Humana Grupo Reproducción |
| dc.publisher.place.spa.fl_str_mv |
Santiago de Chile, Chile |
| institution |
Universidad de Antioquia |
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https://bibliotecadigital.udea.edu.co/bitstream/10495/21966/1/GomezAlejandra_2015_GlicanosVellosidadTrofoblastica.pdf https://bibliotecadigital.udea.edu.co/bitstream/10495/21966/3/license.txt https://bibliotecadigital.udea.edu.co/bitstream/10495/21966/2/license_rdf |
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| spelling |
Gómez Gutiérrez, Alejandra MaríaParra Sosa, Beatriz ElenaBueno Sánchez, Julio César2021-08-30T12:01:07Z2021-08-30T12:01:07Z20150716-1549http://hdl.handle.net/10495/2196610.4067/S0717-75182015000200002.0717-7518ABSTRACT:Glycoproteins attached to cell membrane of syncytiotrophoblast are in close contact with maternal blood, thus these molecules could participate in cell-to-cell communication and biological functions involving ligand-receptors in the maternal-fetal interphase. The attached glycans are involved in the stability, folding and exportation of the protein towards the cell membrane. The objective of this study was to characterize the glycan profi le of third trimester placental villi obtained from pregnant women with early-onset severe preeclampsia and gestational anemia compared with normal pregnant women. Protein extracts from placental villi were used in lectin blot assays. -2,3 N- and O-linked sialic acid was over-expressed in villous of severe preeclamptic placentas measured by MAA lectin staining. High mannose glycans and Gal-GlcNAc patterns were also increased in severe preeclampsia compared with the other groups. These findings can explain changes in the cell membrane expression of glycoproteins.COL0000407COL000763110application/pdfspaSociedad Chilena de Nutrición, Bromatología y ToxicologíaAlimentación y Nutrición HumanaGrupo ReproducciónSantiago de Chile, Chileinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc/4.0/Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia graveGlycans in villus trophoblast in iron defi ciency anemia and early-onset severe preeclampsiaGlycosylationGlicosilaciónAnemiaAnaemiaEarly-onset severe preeclampsiaTransferrin-receptor 1http://aims.fao.org/aos/agrovoc/c_380Rev. Chil. Nutr.Revista Chilena de Nutrición121130422ORIGINALGomezAlejandra_2015_GlicanosVellosidadTrofoblastica.pdfGomezAlejandra_2015_GlicanosVellosidadTrofoblastica.pdfArtículo de investigaciónapplication/pdf214772https://bibliotecadigital.udea.edu.co/bitstream/10495/21966/1/GomezAlejandra_2015_GlicanosVellosidadTrofoblastica.pdf2b1c68d28befe1e526d6484be7dd3b80MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/21966/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8933https://bibliotecadigital.udea.edu.co/bitstream/10495/21966/2/license_rdfc0c92b0ffc8b7d22d9cf56754a416a76MD5210495/21966oai:bibliotecadigital.udea.edu.co:10495/219662021-10-25 13:40:20.815Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |