Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis

ABSTRACT: Sepsis is a very complex clinical phenomenon in both its definition and pathophysiology. So far its diagnosis has been based only on clinical symptoms and signs together with the results of some laboratory tests. However, efforts are being done to find biomarkers that are able to identify...

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Autores:
Londoño Agudelo, Jessica María
Jaimes Barragán, Fabián Alberto
Hoyos Vanegas, Natalia Andrea
Niño Pulido, César Daniel
Tipo de recurso:
Review article
Fecha de publicación:
2013
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
spa
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/13029
Acceso en línea:
http://hdl.handle.net/10495/13029
Palabra clave:
Choque Séptico
Diagnóstico
Pronóstico
Sepsis
Rights
openAccess
License
Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
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dc.title.spa.fl_str_mv Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis
dc.title.alternative.spa.fl_str_mv Use of biomarkers for diagnosis and treatment of sepsis
title Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis
spellingShingle Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis
Choque Séptico
Diagnóstico
Pronóstico
Sepsis
title_short Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis
title_full Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis
title_fullStr Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis
title_full_unstemmed Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis
title_sort Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis
dc.creator.fl_str_mv Londoño Agudelo, Jessica María
Jaimes Barragán, Fabián Alberto
Hoyos Vanegas, Natalia Andrea
Niño Pulido, César Daniel
dc.contributor.author.none.fl_str_mv Londoño Agudelo, Jessica María
Jaimes Barragán, Fabián Alberto
Hoyos Vanegas, Natalia Andrea
Niño Pulido, César Daniel
dc.subject.none.fl_str_mv Choque Séptico
Diagnóstico
Pronóstico
Sepsis
topic Choque Séptico
Diagnóstico
Pronóstico
Sepsis
description ABSTRACT: Sepsis is a very complex clinical phenomenon in both its definition and pathophysiology. So far its diagnosis has been based only on clinical symptoms and signs together with the results of some laboratory tests. However, efforts are being done to find biomarkers that are able to identify sepsis or rule it out, and to serve as guide for treatment. Objective: This review describes the most thoroughly studied biomarkers of sepsis and their potential use, as well as the experience achieved in Medellín, Colombia, with research in this field. Methods: A search on this subject matter was carried out in PubMed, and a critical analysis was done of the most relevant papers found including those published in Colombia. Results and conclusions: More than 180 biomarkers have been studied, most of them for diagnostic and prognostic purposes. Unfortunately, none of them has exhibited the sensitivity and specificity required to be recommended for routine clinical practice. So far, procalcitonin has been the most promising biomarker. Doubtless, this line of research should be continued and reinforced.
publishDate 2013
dc.date.issued.none.fl_str_mv 2013
dc.date.accessioned.none.fl_str_mv 2020-01-10T21:39:20Z
dc.date.available.none.fl_str_mv 2020-01-10T21:39:20Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.local.spa.fl_str_mv Artículo de revisión
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dc.identifier.citation.spa.fl_str_mv Londoño Agudelo JM, Jaimes Barragán FA, Hoyos Vanegas NA, Niño Pulido CD. Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis. Iatreia. 2013 Oct-Dic;26(4):457-466.
dc.identifier.issn.none.fl_str_mv 0121-0793
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/13029
dc.identifier.eissn.none.fl_str_mv 2011-7965
identifier_str_mv Londoño Agudelo JM, Jaimes Barragán FA, Hoyos Vanegas NA, Niño Pulido CD. Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis. Iatreia. 2013 Oct-Dic;26(4):457-466.
0121-0793
2011-7965
url http://hdl.handle.net/10495/13029
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language spa
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Iatreia
dc.rights.*.fl_str_mv Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
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dc.publisher.spa.fl_str_mv Universidad de Antioquia, Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Medellín, Colombia
institution Universidad de Antioquia
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spelling Londoño Agudelo, Jessica MaríaJaimes Barragán, Fabián AlbertoHoyos Vanegas, Natalia AndreaNiño Pulido, César Daniel2020-01-10T21:39:20Z2020-01-10T21:39:20Z2013Londoño Agudelo JM, Jaimes Barragán FA, Hoyos Vanegas NA, Niño Pulido CD. Uso de biomarcadores en el diagnóstico y el tratamiento de la sepsis. Iatreia. 2013 Oct-Dic;26(4):457-466.0121-0793http://hdl.handle.net/10495/130292011-7965ABSTRACT: Sepsis is a very complex clinical phenomenon in both its definition and pathophysiology. So far its diagnosis has been based only on clinical symptoms and signs together with the results of some laboratory tests. However, efforts are being done to find biomarkers that are able to identify sepsis or rule it out, and to serve as guide for treatment. Objective: This review describes the most thoroughly studied biomarkers of sepsis and their potential use, as well as the experience achieved in Medellín, Colombia, with research in this field. Methods: A search on this subject matter was carried out in PubMed, and a critical analysis was done of the most relevant papers found including those published in Colombia. Results and conclusions: More than 180 biomarkers have been studied, most of them for diagnostic and prognostic purposes. Unfortunately, none of them has exhibited the sensitivity and specificity required to be recommended for routine clinical practice. So far, procalcitonin has been the most promising biomarker. Doubtless, this line of research should be continued and reinforced.RESUMEN: La sepsis es un fenómeno clínico muy complejo tanto en su definición como en su fisiopatología. Hasta ahora su diagnóstico se ha basado solo en los síntomas y signos clínicos junto con los hallazgos de las pruebas de laboratorio. Por esta razón se ha tratado de encontrar biomarcadores que puedan identificar la sepsis o descartarla y servir como guía para el tratamiento. Objetivos: esta revisión describe los biomarcadores más estudiados en sepsis y su uso potencial, junto con la experiencia lograda con la investigación al respecto en Medellín, Colombia. Metodología: se llevó a cabo una búsqueda en la base de datos de PubMed y se hizo un análisis crítico de la literatura más relevante incluyendo los estudios publicados en Colombia sobre este asunto. Resultados y conclusiones: se han estudiado más de 180 biomarcadores, la mayoría con fines de diagnóstico temprano y de pronóstico. Ninguno ha sido lo suficientemente sensible y específico como para recomendarlo de rutina en la práctica clínica. La procalcitonina es, probablemente, el biomarcador más promisorio hasta ahora; es indudable que esta línea de investigación debe continuar abierta y en crecimiento.9application/pdfspaUniversidad de Antioquia, Facultad de MedicinaMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVArtículo de revisiónhttp://purl.org/coar/version/c_970fb48d4fbd8a85Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Choque SépticoDiagnósticoPronósticoSepsisUso de biomarcadores en el diagnóstico y el tratamiento de la sepsisUse of biomarkers for diagnosis and treatment of sepsisIatreiaIatreia457466264ORIGINALLondoñoJessica_2013_BiomarcadoresDiagnosticoSepsis.pdfLondoñoJessica_2013_BiomarcadoresDiagnosticoSepsis.pdfArtículo de revisiónapplication/pdf635688http://bibliotecadigital.udea.edu.co/bitstream/10495/13029/1/Londo%c3%b1oJessica_2013_BiomarcadoresDiagnosticoSepsis.pdf924dc6530e120fb6688c5916f78d32eaMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://bibliotecadigital.udea.edu.co/bitstream/10495/13029/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/13029/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://bibliotecadigital.udea.edu.co/bitstream/10495/13029/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/13029/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5510495/13029oai:bibliotecadigital.udea.edu.co:10495/130292021-04-03 16:59:05.592Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=