Furan type lignans with antimycobacterial activity
ABSTRACT: Compounds such as triclosan, diclofenac and trimetropin posses antibacterial activity, including mycobacterial; their structures are based on two aromatic rings joined by a methylene or a heteroatom. Since a similar structural system is found in natural diarylfuranbased lignans, we studied...
- Autores:
-
Baquero Salazar, Eduard
Quiñones Fletcher, Winston
Franzblau, Scott
Torres Roldán, Fernando
Archbold Joseph, Rosendo
Echeverri López, Luis Fernando
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/22184
- Acceso en línea:
- http://hdl.handle.net/10495/22184
- Palabra clave:
- Anti-Bacterial Agents
Antibacterianos
Lignans
Lignanas
Tuberculosis
Bioassays
Ensayo biológico
Arylfuran
http://aims.fao.org/aos/agrovoc/c_36421
http://aims.fao.org/aos/agrovoc/c_7997
http://aims.fao.org/aos/agrovoc/c_15731
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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| dc.title.spa.fl_str_mv |
Furan type lignans with antimycobacterial activity |
| dc.title.alternative.spa.fl_str_mv |
Lignanos del tipo furano con actividad antimicobacterial |
| title |
Furan type lignans with antimycobacterial activity |
| spellingShingle |
Furan type lignans with antimycobacterial activity Anti-Bacterial Agents Antibacterianos Lignans Lignanas Tuberculosis Bioassays Ensayo biológico Arylfuran http://aims.fao.org/aos/agrovoc/c_36421 http://aims.fao.org/aos/agrovoc/c_7997 http://aims.fao.org/aos/agrovoc/c_15731 |
| title_short |
Furan type lignans with antimycobacterial activity |
| title_full |
Furan type lignans with antimycobacterial activity |
| title_fullStr |
Furan type lignans with antimycobacterial activity |
| title_full_unstemmed |
Furan type lignans with antimycobacterial activity |
| title_sort |
Furan type lignans with antimycobacterial activity |
| dc.creator.fl_str_mv |
Baquero Salazar, Eduard Quiñones Fletcher, Winston Franzblau, Scott Torres Roldán, Fernando Archbold Joseph, Rosendo Echeverri López, Luis Fernando |
| dc.contributor.author.none.fl_str_mv |
Baquero Salazar, Eduard Quiñones Fletcher, Winston Franzblau, Scott Torres Roldán, Fernando Archbold Joseph, Rosendo Echeverri López, Luis Fernando |
| dc.subject.decs.none.fl_str_mv |
Anti-Bacterial Agents Antibacterianos |
| topic |
Anti-Bacterial Agents Antibacterianos Lignans Lignanas Tuberculosis Bioassays Ensayo biológico Arylfuran http://aims.fao.org/aos/agrovoc/c_36421 http://aims.fao.org/aos/agrovoc/c_7997 http://aims.fao.org/aos/agrovoc/c_15731 |
| dc.subject.agrovoc.none.fl_str_mv |
Lignans Lignanas Tuberculosis Bioassays Ensayo biológico |
| dc.subject.proposal.spa.fl_str_mv |
Arylfuran |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_36421 http://aims.fao.org/aos/agrovoc/c_7997 http://aims.fao.org/aos/agrovoc/c_15731 |
| description |
ABSTRACT: Compounds such as triclosan, diclofenac and trimetropin posses antibacterial activity, including mycobacterial; their structures are based on two aromatic rings joined by a methylene or a heteroatom. Since a similar structural system is found in natural diarylfuranbased lignans, we studied plants known with this type of lignans, as potential active against Mycobacterium tuberculosis. Fractions of the active extracts were tested for anti-TB activity and their chemical constituents analyzed by NMR spectroscopy. Several extracts and chromatographical fractions exhibited > 90% inhibition of M. tuberculosis at 128 ug/mL. Methylpluviatilol, a pure compound isolated from Virola sebifera, was active at this concentration. These findings suggest that plant species of the families here studied may yield novel lead compounds for the development of antimycobacterial agents. |
| publishDate |
2015 |
| dc.date.issued.none.fl_str_mv |
2015 |
| dc.date.accessioned.none.fl_str_mv |
2021-09-04T02:48:42Z |
| dc.date.available.none.fl_str_mv |
2021-09-04T02:48:42Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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0717-7917 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/22184 |
| identifier_str_mv |
0717-7917 |
| url |
http://hdl.handle.net/10495/22184 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofseries.spa.fl_str_mv |
Lignanos del tipo furano con actividad antimicobacterial |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Bol. latinoam. Caribe plantas med. aromát. |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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8 |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Cooperación Latinoamericana y Caribeña en Plantas Medicinales y Aromáticas |
| dc.publisher.group.spa.fl_str_mv |
Química Orgánica de Productos Naturales |
| dc.publisher.place.spa.fl_str_mv |
Santiago de Chile, Chile |
| institution |
Universidad de Antioquia |
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Repositorio Institucional Universidad de Antioquia |
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andres.perez@udea.edu.co |
| _version_ |
1805390277858295808 |
| spelling |
Baquero Salazar, EduardQuiñones Fletcher, WinstonFranzblau, ScottTorres Roldán, FernandoArchbold Joseph, RosendoEcheverri López, Luis Fernando2021-09-04T02:48:42Z2021-09-04T02:48:42Z20150717-7917http://hdl.handle.net/10495/22184ABSTRACT: Compounds such as triclosan, diclofenac and trimetropin posses antibacterial activity, including mycobacterial; their structures are based on two aromatic rings joined by a methylene or a heteroatom. Since a similar structural system is found in natural diarylfuranbased lignans, we studied plants known with this type of lignans, as potential active against Mycobacterium tuberculosis. Fractions of the active extracts were tested for anti-TB activity and their chemical constituents analyzed by NMR spectroscopy. Several extracts and chromatographical fractions exhibited > 90% inhibition of M. tuberculosis at 128 ug/mL. Methylpluviatilol, a pure compound isolated from Virola sebifera, was active at this concentration. These findings suggest that plant species of the families here studied may yield novel lead compounds for the development of antimycobacterial agents.RESUMEN: Compuestos tales como triclosan, diclofenac y trimetoprim poseen actividad antibacterial, incluyendo la antimicobacterial; sus estructuras están basadas en dos anillos aromáticos unidos por un metileno o un heteroátomo. Debido a que en la naturaleza se encuentra un sistema estructural similar del tipo diarilfurano en los lignanos, así como otros subtipos, nosotros estudiamos plantas contra Mycobacterium tuberculosis, de las que se sabe contienen lignanos Las fracciones cromatográficas de los extractos activos fueron ensayadas para actividad anti.Tb y sus constituyentes químicos se analizaron por espectroscopía de RMN. Varios extractos y fracciones cromatográficas exhibieron una inhibición superior al 90% a 128 ug/mL; el compuesto metilpluviatilol, aislado de mostró una inhibición del 99% a esa concentración. Esos hechos sugieren que las especies de plantas de las familias aquí estudiadas podrían suministrar nuevos compuestos líderes para el desarrollo de agentes antimicobacteriales.COL00153398application/pdfengCooperación Latinoamericana y Caribeña en Plantas Medicinales y AromáticasQuímica Orgánica de Productos NaturalesSantiago de Chile, ChileLignanos del tipo furano con actividad antimicobacterialBol. latinoam. Caribe plantas med. aromát.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Furan type lignans with antimycobacterial activityLignanos del tipo furano con actividad antimicobacterialAnti-Bacterial AgentsAntibacterianosLignansLignanasTuberculosisBioassaysEnsayo biológicoArylfuranhttp://aims.fao.org/aos/agrovoc/c_36421http://aims.fao.org/aos/agrovoc/c_7997http://aims.fao.org/aos/agrovoc/c_15731Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas171178143CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823http://bibliotecadigital.udea.edu.co/bitstream/10495/22184/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/22184/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53ORIGINALBaqueroEduard_2015_FuranLignansAntimycobacterial.pdfBaqueroEduard_2015_FuranLignansAntimycobacterial.pdfArtículo de investigaciónapplication/pdf436189http://bibliotecadigital.udea.edu.co/bitstream/10495/22184/1/BaqueroEduard_2015_FuranLignansAntimycobacterial.pdf5e1861bd213655d91184fdd23622637fMD5110495/22184oai:bibliotecadigital.udea.edu.co:10495/221842021-09-03 21:48:43.074Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |