Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms
ABSTRACT: Three horse-derived antivenoms were tested for their ability to neu-tralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxicactivitiesinduced by the venom of Bothrops atrox from Antioquia andChocó (Colombia). The following antivenoms were used: a) polyva-lent (crotaline) anti...
- Autores:
-
Valle Agudelo, Gustavo del
Estrada, Ricardo
Valderrama Hernández, Rafael
Robles, Abel
Osorio Gutiérrez, Raúl Guillermo
Gutiérrez Gutiérrez, José María
Otero Patiño, Rafael
Giraldo, César Augusto
Núñez Rangel, Vitelbina
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 1997
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/25225
- Acceso en línea:
- http://hdl.handle.net/10495/25225
- Palabra clave:
- Bothrops
Venenos de Serpiente
Snake Venoms
Neutralización
Neutralization
Antioquia (Colombia)
Chocó (Colombia)
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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|
| dc.title.spa.fl_str_mv |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms |
| title |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms |
| spellingShingle |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms Bothrops Venenos de Serpiente Snake Venoms Neutralización Neutralization Antioquia (Colombia) Chocó (Colombia) |
| title_short |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms |
| title_full |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms |
| title_fullStr |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms |
| title_full_unstemmed |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms |
| title_sort |
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms |
| dc.creator.fl_str_mv |
Valle Agudelo, Gustavo del Estrada, Ricardo Valderrama Hernández, Rafael Robles, Abel Osorio Gutiérrez, Raúl Guillermo Gutiérrez Gutiérrez, José María Otero Patiño, Rafael Giraldo, César Augusto Núñez Rangel, Vitelbina |
| dc.contributor.author.none.fl_str_mv |
Valle Agudelo, Gustavo del Estrada, Ricardo Valderrama Hernández, Rafael Robles, Abel Osorio Gutiérrez, Raúl Guillermo Gutiérrez Gutiérrez, José María Otero Patiño, Rafael Giraldo, César Augusto Núñez Rangel, Vitelbina |
| dc.subject.decs.none.fl_str_mv |
Bothrops Venenos de Serpiente Snake Venoms Neutralización Neutralization |
| topic |
Bothrops Venenos de Serpiente Snake Venoms Neutralización Neutralization Antioquia (Colombia) Chocó (Colombia) |
| dc.subject.lemb.none.fl_str_mv |
Antioquia (Colombia) Chocó (Colombia) |
| description |
ABSTRACT: Three horse-derived antivenoms were tested for their ability to neu-tralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxicactivitiesinduced by the venom of Bothrops atrox from Antioquia andChocó (Colombia). The following antivenoms were used: a) polyva-lent (crotaline) antivenom produced by Instituto Clodomiro Picado(Costa Rica), b) monovalent antibothropic antivenom produced byInstituto Nacional de Salud-INS (Bogotá), and c) a new monovalentanti-B. atrox antivenom produced with the venom of B. atrox fromAntioquia and Chocó. The three antivenoms neutralized alltoxicactivitiestested albeit with different potencies. The new monovalentanti-B. atrox antivenomshowed the highest neutralizing ability againstedema-forming and defibrinating effects of B. atrox venom (41 ± 2and 100 ± 32 μl antivenom/mgvenom, respectively), suggesting thatitshould be usefulin the treatment of B. atrox envenomation inAntioquia and Chocó. |
| publishDate |
1997 |
| dc.date.issued.none.fl_str_mv |
1997 |
| dc.date.accessioned.none.fl_str_mv |
2022-01-12T16:23:17Z |
| dc.date.available.none.fl_str_mv |
2022-01-12T16:23:17Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.local.spa.fl_str_mv |
Artículo de investigación |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Otero R, Núñez V, Gutiérrez J, Robles A, Estrada R, Osorio R, Del-Valle G, et al. Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms. Braz J Med Biol Res1997;30(3):375-9. |
| dc.identifier.issn.none.fl_str_mv |
0100-879X |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/25225 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X1997000300011 |
| dc.identifier.eissn.none.fl_str_mv |
1414-431X |
| identifier_str_mv |
Otero R, Núñez V, Gutiérrez J, Robles A, Estrada R, Osorio R, Del-Valle G, et al. Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms. Braz J Med Biol Res1997;30(3):375-9. 0100-879X 10.1590/S0100-879X1997000300011 1414-431X |
| url |
http://hdl.handle.net/10495/25225 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Braz. J. Med. Biol. Res. |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Associação Brasileira de Divulgação Científica |
| dc.publisher.group.spa.fl_str_mv |
Toxinología Alternativas Terapéuticas y Alimentarias |
| dc.publisher.place.spa.fl_str_mv |
São Paulo, Brasil |
| institution |
Universidad de Antioquia |
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Valle Agudelo, Gustavo delEstrada, RicardoValderrama Hernández, RafaelRobles, AbelOsorio Gutiérrez, Raúl GuillermoGutiérrez Gutiérrez, José MaríaOtero Patiño, RafaelGiraldo, César AugustoNúñez Rangel, Vitelbina2022-01-12T16:23:17Z2022-01-12T16:23:17Z1997Otero R, Núñez V, Gutiérrez J, Robles A, Estrada R, Osorio R, Del-Valle G, et al. Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms. Braz J Med Biol Res1997;30(3):375-9.0100-879Xhttp://hdl.handle.net/10495/2522510.1590/S0100-879X19970003000111414-431XABSTRACT: Three horse-derived antivenoms were tested for their ability to neu-tralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxicactivitiesinduced by the venom of Bothrops atrox from Antioquia andChocó (Colombia). The following antivenoms were used: a) polyva-lent (crotaline) antivenom produced by Instituto Clodomiro Picado(Costa Rica), b) monovalent antibothropic antivenom produced byInstituto Nacional de Salud-INS (Bogotá), and c) a new monovalentanti-B. atrox antivenom produced with the venom of B. atrox fromAntioquia and Chocó. The three antivenoms neutralized alltoxicactivitiestested albeit with different potencies. The new monovalentanti-B. atrox antivenomshowed the highest neutralizing ability againstedema-forming and defibrinating effects of B. atrox venom (41 ± 2and 100 ± 32 μl antivenom/mgvenom, respectively), suggesting thatitshould be usefulin the treatment of B. atrox envenomation inAntioquia and Chocó.COL00144765application/pdfengAssociação Brasileira de Divulgação CientíficaToxinología Alternativas Terapéuticas y AlimentariasSão Paulo, Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenomsBothropsVenenos de SerpienteSnake VenomsNeutralizaciónNeutralizationAntioquia (Colombia)Chocó (Colombia)Braz. J. Med. Biol. Res.Brazilian Journal of Medical and Biological Research375379303CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051http://bibliotecadigital.udea.edu.co/bitstream/10495/25225/2/license_rdfe2060682c9c70d4d30c83c51448f4eedMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/25225/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53ORIGINALDelValleGustavo_1997_NeutralizingCapacityMonovalent.pdfDelValleGustavo_1997_NeutralizingCapacityMonovalent.pdfArtículo de investigaciónapplication/pdf327404http://bibliotecadigital.udea.edu.co/bitstream/10495/25225/1/DelValleGustavo_1997_NeutralizingCapacityMonovalent.pdff18a606551be6638f6bb7f77c866b24cMD5110495/25225oai:bibliotecadigital.udea.edu.co:10495/252252022-01-12 11:24:38.845Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |