Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
ABSTRACT: Background: Chronic osteomyelitis (COM) is very difficult to cure without proper identification of the bone-infecting organism and it is not clear whether specimens other than bone are appropriate for microbiological diagnosis because results from available studies are conflicting. Methods...
- Autores:
-
Zuluaga Salazar, Andrés Felipe
Galvis Franco, William
Saldarriaga, Juan Guillermo
Salazar Giraldo, Beatriz
Vesga Meneses, Omar
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2003
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/26415
- Acceso en línea:
- http://hdl.handle.net/10495/26415
- Palabra clave:
- Osteomielitis
Osteomyelitis
Huesos
Bone and Bones
- Rights
- openAccess
- License
- http://purl.org/coar/access_right/c_abf2
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oai:bibliotecadigital.udea.edu.co:10495/26415 |
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UDEA2 |
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Repositorio UdeA |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients |
title |
Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients |
spellingShingle |
Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients Osteomielitis Osteomyelitis Huesos Bone and Bones |
title_short |
Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients |
title_full |
Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients |
title_fullStr |
Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients |
title_full_unstemmed |
Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients |
title_sort |
Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients |
dc.creator.fl_str_mv |
Zuluaga Salazar, Andrés Felipe Galvis Franco, William Saldarriaga, Juan Guillermo Salazar Giraldo, Beatriz Vesga Meneses, Omar |
dc.contributor.author.none.fl_str_mv |
Zuluaga Salazar, Andrés Felipe Galvis Franco, William Saldarriaga, Juan Guillermo Salazar Giraldo, Beatriz Vesga Meneses, Omar |
dc.subject.decs.none.fl_str_mv |
Osteomielitis Osteomyelitis Huesos Bone and Bones |
topic |
Osteomielitis Osteomyelitis Huesos Bone and Bones |
description |
ABSTRACT: Background: Chronic osteomyelitis (COM) is very difficult to cure without proper identification of the bone-infecting organism and it is not clear whether specimens other than bone are appropriate for microbiological diagnosis because results from available studies are conflicting. Methods: Prospective analysis of 100 patients with COM in a 500-bed University-based hospital, comparing the microbiology from specimens other than bone with that of bone cultures, taking the last as the gold standard. Results: Time of evolution of COM was 1 to 384 days (median 180 days), 72% of patients were male, mean age was 38±18 years. Femur and tibia accounted for 72% of the infected bones; most had trauma and/or surgery (85%) as predisposing factors. The microbiology of speci- mens other than bone was identical to that found after simultaneous bone cultures in 30%; concordance for Staphylococcus aureus was 41% and for other microorganisms 18%. These concordance rates correspond to 74% sensibility, 6% specificity, 30% positive predictive value, and 31% negative predictive value. Anaerobic bacteria were isolated from the bone in 13% of patients. Conclusions: Diagnosis and therapy of chronic osteomyelitis cannot be guided by cultures of non-bone specimens because their microbiology is substantially different to the microbiology of the infected bone. |
publishDate |
2003 |
dc.date.issued.none.fl_str_mv |
2003 |
dc.date.accessioned.none.fl_str_mv |
2022-03-05T15:34:05Z |
dc.date.available.none.fl_str_mv |
2022-03-05T15:34:05Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
0733-6373 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/26415 |
identifier_str_mv |
0733-6373 |
url |
http://hdl.handle.net/10495/26415 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
Derechos reservados - Está prohibida la reproducción parcial o total de esta publicación |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://purl.org/coar/access_right/c_abf2 Derechos reservados - Está prohibida la reproducción parcial o total de esta publicación |
dc.format.extent.spa.fl_str_mv |
1 |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
American Society for Microbiology |
dc.publisher.group.spa.fl_str_mv |
GRIPE: Grupo Investigador de Problemas en Enfermedades Infecciosas |
dc.publisher.place.spa.fl_str_mv |
washington, Estados Unidos |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/26415/3/AndresZuluaha_2003_SpecimenesChronicOsteomyelitis.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/26415/2/license.txt |
bitstream.checksum.fl_str_mv |
c1ff3c97a5383d29475ab027fe3bc968 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
_version_ |
1812173106657099776 |
spelling |
Zuluaga Salazar, Andrés FelipeGalvis Franco, WilliamSaldarriaga, Juan GuillermoSalazar Giraldo, BeatrizVesga Meneses, Omar2022-03-05T15:34:05Z2022-03-05T15:34:05Z20030733-6373http://hdl.handle.net/10495/26415ABSTRACT: Background: Chronic osteomyelitis (COM) is very difficult to cure without proper identification of the bone-infecting organism and it is not clear whether specimens other than bone are appropriate for microbiological diagnosis because results from available studies are conflicting. Methods: Prospective analysis of 100 patients with COM in a 500-bed University-based hospital, comparing the microbiology from specimens other than bone with that of bone cultures, taking the last as the gold standard. Results: Time of evolution of COM was 1 to 384 days (median 180 days), 72% of patients were male, mean age was 38±18 years. Femur and tibia accounted for 72% of the infected bones; most had trauma and/or surgery (85%) as predisposing factors. The microbiology of speci- mens other than bone was identical to that found after simultaneous bone cultures in 30%; concordance for Staphylococcus aureus was 41% and for other microorganisms 18%. These concordance rates correspond to 74% sensibility, 6% specificity, 30% positive predictive value, and 31% negative predictive value. Anaerobic bacteria were isolated from the bone in 13% of patients. Conclusions: Diagnosis and therapy of chronic osteomyelitis cannot be guided by cultures of non-bone specimens because their microbiology is substantially different to the microbiology of the infected bone.COL00057441application/pdfengAmerican Society for MicrobiologyGRIPE: Grupo Investigador de Problemas en Enfermedades Infecciosaswashington, Estados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Derechos reservados - Está prohibida la reproducción parcial o total de esta publicaciónSpecimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patientsOsteomielitisOsteomyelitisHuesosBone and BonesAbstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy365365431ORIGINALAndresZuluaha_2003_SpecimenesChronicOsteomyelitis.pdfAndresZuluaha_2003_SpecimenesChronicOsteomyelitis.pdfArtículo de investigaciónapplication/pdf476055http://bibliotecadigital.udea.edu.co/bitstream/10495/26415/3/AndresZuluaha_2003_SpecimenesChronicOsteomyelitis.pdfc1ff3c97a5383d29475ab027fe3bc968MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/26415/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5210495/26415oai:bibliotecadigital.udea.edu.co:10495/264152022-03-05 10:35:15.133Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |