Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients

ABSTRACT: Background: Chronic osteomyelitis (COM) is very difficult to cure without proper identification of the bone-infecting organism and it is not clear whether specimens other than bone are appropriate for microbiological diagnosis because results from available studies are conflicting. Methods...

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Autores:
Zuluaga Salazar, Andrés Felipe
Galvis Franco, William
Saldarriaga, Juan Guillermo
Salazar Giraldo, Beatriz
Vesga Meneses, Omar
Tipo de recurso:
Article of investigation
Fecha de publicación:
2003
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/26415
Acceso en línea:
http://hdl.handle.net/10495/26415
Palabra clave:
Osteomielitis
Osteomyelitis
Huesos
Bone and Bones
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id UDEA2_306e88400b139b794688d80e4c714bd6
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/26415
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
title Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
spellingShingle Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
Osteomielitis
Osteomyelitis
Huesos
Bone and Bones
title_short Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
title_full Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
title_fullStr Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
title_full_unstemmed Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
title_sort Specimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patients
dc.creator.fl_str_mv Zuluaga Salazar, Andrés Felipe
Galvis Franco, William
Saldarriaga, Juan Guillermo
Salazar Giraldo, Beatriz
Vesga Meneses, Omar
dc.contributor.author.none.fl_str_mv Zuluaga Salazar, Andrés Felipe
Galvis Franco, William
Saldarriaga, Juan Guillermo
Salazar Giraldo, Beatriz
Vesga Meneses, Omar
dc.subject.decs.none.fl_str_mv Osteomielitis
Osteomyelitis
Huesos
Bone and Bones
topic Osteomielitis
Osteomyelitis
Huesos
Bone and Bones
description ABSTRACT: Background: Chronic osteomyelitis (COM) is very difficult to cure without proper identification of the bone-infecting organism and it is not clear whether specimens other than bone are appropriate for microbiological diagnosis because results from available studies are conflicting. Methods: Prospective analysis of 100 patients with COM in a 500-bed University-based hospital, comparing the microbiology from specimens other than bone with that of bone cultures, taking the last as the gold standard. Results: Time of evolution of COM was 1 to 384 days (median 180 days), 72% of patients were male, mean age was 38±18 years. Femur and tibia accounted for 72% of the infected bones; most had trauma and/or surgery (85%) as predisposing factors. The microbiology of speci- mens other than bone was identical to that found after simultaneous bone cultures in 30%; concordance for Staphylococcus aureus was 41% and for other microorganisms 18%. These concordance rates correspond to 74% sensibility, 6% specificity, 30% positive predictive value, and 31% negative predictive value. Anaerobic bacteria were isolated from the bone in 13% of patients. Conclusions: Diagnosis and therapy of chronic osteomyelitis cannot be guided by cultures of non-bone specimens because their microbiology is substantially different to the microbiology of the infected bone.
publishDate 2003
dc.date.issued.none.fl_str_mv 2003
dc.date.accessioned.none.fl_str_mv 2022-03-05T15:34:05Z
dc.date.available.none.fl_str_mv 2022-03-05T15:34:05Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
dc.type.local.spa.fl_str_mv Artículo de investigación
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 0733-6373
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/26415
identifier_str_mv 0733-6373
url http://hdl.handle.net/10495/26415
dc.language.iso.spa.fl_str_mv eng
language eng
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.accessrights.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons.spa.fl_str_mv Derechos reservados - Está prohibida la reproducción parcial o total de esta publicación
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
Derechos reservados - Está prohibida la reproducción parcial o total de esta publicación
dc.format.extent.spa.fl_str_mv 1
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv American Society for Microbiology
dc.publisher.group.spa.fl_str_mv GRIPE: Grupo Investigador de Problemas en Enfermedades Infecciosas
dc.publisher.place.spa.fl_str_mv washington, Estados Unidos
institution Universidad de Antioquia
bitstream.url.fl_str_mv http://bibliotecadigital.udea.edu.co/bitstream/10495/26415/3/AndresZuluaha_2003_SpecimenesChronicOsteomyelitis.pdf
http://bibliotecadigital.udea.edu.co/bitstream/10495/26415/2/license.txt
bitstream.checksum.fl_str_mv c1ff3c97a5383d29475ab027fe3bc968
8a4605be74aa9ea9d79846c1fba20a33
bitstream.checksumAlgorithm.fl_str_mv MD5
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repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
repository.mail.fl_str_mv andres.perez@udea.edu.co
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spelling Zuluaga Salazar, Andrés FelipeGalvis Franco, WilliamSaldarriaga, Juan GuillermoSalazar Giraldo, BeatrizVesga Meneses, Omar2022-03-05T15:34:05Z2022-03-05T15:34:05Z20030733-6373http://hdl.handle.net/10495/26415ABSTRACT: Background: Chronic osteomyelitis (COM) is very difficult to cure without proper identification of the bone-infecting organism and it is not clear whether specimens other than bone are appropriate for microbiological diagnosis because results from available studies are conflicting. Methods: Prospective analysis of 100 patients with COM in a 500-bed University-based hospital, comparing the microbiology from specimens other than bone with that of bone cultures, taking the last as the gold standard. Results: Time of evolution of COM was 1 to 384 days (median 180 days), 72% of patients were male, mean age was 38±18 years. Femur and tibia accounted for 72% of the infected bones; most had trauma and/or surgery (85%) as predisposing factors. The microbiology of speci- mens other than bone was identical to that found after simultaneous bone cultures in 30%; concordance for Staphylococcus aureus was 41% and for other microorganisms 18%. These concordance rates correspond to 74% sensibility, 6% specificity, 30% positive predictive value, and 31% negative predictive value. Anaerobic bacteria were isolated from the bone in 13% of patients. Conclusions: Diagnosis and therapy of chronic osteomyelitis cannot be guided by cultures of non-bone specimens because their microbiology is substantially different to the microbiology of the infected bone.COL00057441application/pdfengAmerican Society for MicrobiologyGRIPE: Grupo Investigador de Problemas en Enfermedades Infecciosaswashington, Estados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Derechos reservados - Está prohibida la reproducción parcial o total de esta publicaciónSpecimens other than bone are not acceptable for microbiological diagnosis of chronic osteomyelitis. Prospective study with 100 patientsOsteomielitisOsteomyelitisHuesosBone and BonesAbstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy365365431ORIGINALAndresZuluaha_2003_SpecimenesChronicOsteomyelitis.pdfAndresZuluaha_2003_SpecimenesChronicOsteomyelitis.pdfArtículo de investigaciónapplication/pdf476055http://bibliotecadigital.udea.edu.co/bitstream/10495/26415/3/AndresZuluaha_2003_SpecimenesChronicOsteomyelitis.pdfc1ff3c97a5383d29475ab027fe3bc968MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/26415/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5210495/26415oai:bibliotecadigital.udea.edu.co:10495/264152022-03-05 10:35:15.133Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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