Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
ABSTRACT: Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological...
- Autores:
-
Álvarez Larrotta, Catalina
Agudelo García, Olga María
Gavina, Kenneth
Yanow, Stephanie Kim
Maestre Buitrago, Amanda Elena
Carmona Fonseca, Jaime
Arango Flórez, Eliana María
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/32164
- Acceso en línea:
- https://hdl.handle.net/10495/32164
- Palabra clave:
- Citocinas
Cytokines
Anticuerpos Antibacterianos
Antibodies, Bacterial
Enfermedad Crónica
Chronic Disease
Linfocitos T Reguladores
T-Lymphocytes, Regulatory
Malaria
Plasmodium falciparum
Plasmodium vivax
Vacunas
Vaccines
Complicaciones Infecciosas del Embarazo
Pregnancy Complications, Infectious
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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|
dc.title.spa.fl_str_mv |
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid |
title |
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid |
spellingShingle |
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid Citocinas Cytokines Anticuerpos Antibacterianos Antibodies, Bacterial Enfermedad Crónica Chronic Disease Linfocitos T Reguladores T-Lymphocytes, Regulatory Malaria Plasmodium falciparum Plasmodium vivax Vacunas Vaccines Complicaciones Infecciosas del Embarazo Pregnancy Complications, Infectious |
title_short |
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid |
title_full |
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid |
title_fullStr |
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid |
title_full_unstemmed |
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid |
title_sort |
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid |
dc.creator.fl_str_mv |
Álvarez Larrotta, Catalina Agudelo García, Olga María Gavina, Kenneth Yanow, Stephanie Kim Maestre Buitrago, Amanda Elena Carmona Fonseca, Jaime Arango Flórez, Eliana María |
dc.contributor.author.none.fl_str_mv |
Álvarez Larrotta, Catalina Agudelo García, Olga María Gavina, Kenneth Yanow, Stephanie Kim Maestre Buitrago, Amanda Elena Carmona Fonseca, Jaime Arango Flórez, Eliana María |
dc.subject.decs.none.fl_str_mv |
Citocinas Cytokines Anticuerpos Antibacterianos Antibodies, Bacterial Enfermedad Crónica Chronic Disease Linfocitos T Reguladores T-Lymphocytes, Regulatory Malaria Plasmodium falciparum Plasmodium vivax Vacunas Vaccines Complicaciones Infecciosas del Embarazo Pregnancy Complications, Infectious |
topic |
Citocinas Cytokines Anticuerpos Antibacterianos Antibodies, Bacterial Enfermedad Crónica Chronic Disease Linfocitos T Reguladores T-Lymphocytes, Regulatory Malaria Plasmodium falciparum Plasmodium vivax Vacunas Vaccines Complicaciones Infecciosas del Embarazo Pregnancy Complications, Infectious |
description |
ABSTRACT: Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological conditions for parasite transmission fluctuate. In chronic infections, the persistence of the antigenic stimulus changes the expression of immune mediators and promotes constant immune regulation, including increases in regulatory T cell populations. These alterations of the immune system could compromise the response to routine vaccination. This study aimed to evaluate the effect of submicroscopic plasmodial infection with P. falciparum and P. vivax during pregnancy on the immune response to the tetanus toxoid vaccine in Colombian women. Expression of different cytokines and mediators of immune regulation and levels of anti-tetanus toxoid (TT) immunoglobulin (Ig)G were quantified in pregnant women with and without submicroscopic plasmodial infection. The anti-TT IgG levels were significantly lower in the infected group compared with the uninfected group. The expression of interferon (IFN)-γ, tumour necrosis factor (TNF) and forkhead box protein 3 (FoxP3) was significantly higher in the infected group, while the expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and transforming growth factor (TGF)-β was lower in the group of infected. In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration. |
publishDate |
2019 |
dc.date.issued.none.fl_str_mv |
2019 |
dc.date.accessioned.none.fl_str_mv |
2022-11-21T14:49:51Z |
dc.date.available.none.fl_str_mv |
2022-11-21T14:49:51Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.citation.spa.fl_str_mv |
Álvarez-Larrotta C, Agudelo OM, Duque Y, Gavina K, Yanow SK, Maestre A, Carmona-Fonseca J, Arango E. Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid. Clin Exp Immunol. 2019 Jan;195(1):96-108. doi: 10.1111/cei.13213. |
dc.identifier.issn.none.fl_str_mv |
0009-9104 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/32164 |
dc.identifier.doi.none.fl_str_mv |
10.1111/cei.13213 |
dc.identifier.eissn.none.fl_str_mv |
1365-2249 |
identifier_str_mv |
Álvarez-Larrotta C, Agudelo OM, Duque Y, Gavina K, Yanow SK, Maestre A, Carmona-Fonseca J, Arango E. Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid. Clin Exp Immunol. 2019 Jan;195(1):96-108. doi: 10.1111/cei.13213. 0009-9104 10.1111/cei.13213 1365-2249 |
url |
https://hdl.handle.net/10495/32164 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Clin Exp Immunol |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.format.extent.spa.fl_str_mv |
13 |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
British Society for Immunology |
dc.publisher.group.spa.fl_str_mv |
Salud y Comunidad |
dc.publisher.place.spa.fl_str_mv |
Oxford, Inglaterra |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/1/AlvarezCatalina_2019_PlasmodiumPregnancyReducedAntibody.pdf https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/2/license_rdf https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/3/license.txt |
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MD5 MD5 MD5 |
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Repositorio Institucional Universidad de Antioquia |
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andres.perez@udea.edu.co |
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1812173132578947072 |
spelling |
Álvarez Larrotta, CatalinaAgudelo García, Olga MaríaGavina, KennethYanow, Stephanie KimMaestre Buitrago, Amanda ElenaCarmona Fonseca, JaimeArango Flórez, Eliana María2022-11-21T14:49:51Z2022-11-21T14:49:51Z2019Álvarez-Larrotta C, Agudelo OM, Duque Y, Gavina K, Yanow SK, Maestre A, Carmona-Fonseca J, Arango E. Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid. Clin Exp Immunol. 2019 Jan;195(1):96-108. doi: 10.1111/cei.13213.0009-9104https://hdl.handle.net/10495/3216410.1111/cei.132131365-2249ABSTRACT: Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological conditions for parasite transmission fluctuate. In chronic infections, the persistence of the antigenic stimulus changes the expression of immune mediators and promotes constant immune regulation, including increases in regulatory T cell populations. These alterations of the immune system could compromise the response to routine vaccination. This study aimed to evaluate the effect of submicroscopic plasmodial infection with P. falciparum and P. vivax during pregnancy on the immune response to the tetanus toxoid vaccine in Colombian women. Expression of different cytokines and mediators of immune regulation and levels of anti-tetanus toxoid (TT) immunoglobulin (Ig)G were quantified in pregnant women with and without submicroscopic plasmodial infection. The anti-TT IgG levels were significantly lower in the infected group compared with the uninfected group. The expression of interferon (IFN)-γ, tumour necrosis factor (TNF) and forkhead box protein 3 (FoxP3) was significantly higher in the infected group, while the expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and transforming growth factor (TGF)-β was lower in the group of infected. In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration.COL004744913application/pdfengBritish Society for ImmunologySalud y ComunidadOxford, Inglaterrainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoidCitocinasCytokinesAnticuerpos AntibacterianosAntibodies, BacterialEnfermedad CrónicaChronic DiseaseLinfocitos T ReguladoresT-Lymphocytes, RegulatoryMalariaPlasmodium falciparumPlasmodium vivaxVacunasVaccinesComplicaciones Infecciosas del EmbarazoPregnancy Complications, InfectiousClin Exp ImmunolClinical and Experimental Immunology961081951ORIGINALAlvarezCatalina_2019_PlasmodiumPregnancyReducedAntibody.pdfAlvarezCatalina_2019_PlasmodiumPregnancyReducedAntibody.pdfArtículo de investigaciónapplication/pdf416070https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/1/AlvarezCatalina_2019_PlasmodiumPregnancyReducedAntibody.pdfc6b9212228a22dc940e9896f05303830MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/32164oai:bibliotecadigital.udea.edu.co:10495/321642022-11-21 09:49:51.999Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |