Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

ABSTRACT: Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological...

Full description

Autores:
Álvarez Larrotta, Catalina
Agudelo García, Olga María
Gavina, Kenneth
Yanow, Stephanie Kim
Maestre Buitrago, Amanda Elena
Carmona Fonseca, Jaime
Arango Flórez, Eliana María
Tipo de recurso:
Article of investigation
Fecha de publicación:
2019
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/32164
Acceso en línea:
https://hdl.handle.net/10495/32164
Palabra clave:
Citocinas
Cytokines
Anticuerpos Antibacterianos
Antibodies, Bacterial
Enfermedad Crónica
Chronic Disease
Linfocitos T Reguladores
T-Lymphocytes, Regulatory
Malaria
Plasmodium falciparum
Plasmodium vivax
Vacunas
Vaccines
Complicaciones Infecciosas del Embarazo
Pregnancy Complications, Infectious
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_2cf986460bd94f1ee193724e365fd69c
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/32164
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
title Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
spellingShingle Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
Citocinas
Cytokines
Anticuerpos Antibacterianos
Antibodies, Bacterial
Enfermedad Crónica
Chronic Disease
Linfocitos T Reguladores
T-Lymphocytes, Regulatory
Malaria
Plasmodium falciparum
Plasmodium vivax
Vacunas
Vaccines
Complicaciones Infecciosas del Embarazo
Pregnancy Complications, Infectious
title_short Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
title_full Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
title_fullStr Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
title_full_unstemmed Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
title_sort Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
dc.creator.fl_str_mv Álvarez Larrotta, Catalina
Agudelo García, Olga María
Gavina, Kenneth
Yanow, Stephanie Kim
Maestre Buitrago, Amanda Elena
Carmona Fonseca, Jaime
Arango Flórez, Eliana María
dc.contributor.author.none.fl_str_mv Álvarez Larrotta, Catalina
Agudelo García, Olga María
Gavina, Kenneth
Yanow, Stephanie Kim
Maestre Buitrago, Amanda Elena
Carmona Fonseca, Jaime
Arango Flórez, Eliana María
dc.subject.decs.none.fl_str_mv Citocinas
Cytokines
Anticuerpos Antibacterianos
Antibodies, Bacterial
Enfermedad Crónica
Chronic Disease
Linfocitos T Reguladores
T-Lymphocytes, Regulatory
Malaria
Plasmodium falciparum
Plasmodium vivax
Vacunas
Vaccines
Complicaciones Infecciosas del Embarazo
Pregnancy Complications, Infectious
topic Citocinas
Cytokines
Anticuerpos Antibacterianos
Antibodies, Bacterial
Enfermedad Crónica
Chronic Disease
Linfocitos T Reguladores
T-Lymphocytes, Regulatory
Malaria
Plasmodium falciparum
Plasmodium vivax
Vacunas
Vaccines
Complicaciones Infecciosas del Embarazo
Pregnancy Complications, Infectious
description ABSTRACT: Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological conditions for parasite transmission fluctuate. In chronic infections, the persistence of the antigenic stimulus changes the expression of immune mediators and promotes constant immune regulation, including increases in regulatory T cell populations. These alterations of the immune system could compromise the response to routine vaccination. This study aimed to evaluate the effect of submicroscopic plasmodial infection with P. falciparum and P. vivax during pregnancy on the immune response to the tetanus toxoid vaccine in Colombian women. Expression of different cytokines and mediators of immune regulation and levels of anti-tetanus toxoid (TT) immunoglobulin (Ig)G were quantified in pregnant women with and without submicroscopic plasmodial infection. The anti-TT IgG levels were significantly lower in the infected group compared with the uninfected group. The expression of interferon (IFN)-γ, tumour necrosis factor (TNF) and forkhead box protein 3 (FoxP3) was significantly higher in the infected group, while the expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and transforming growth factor (TGF)-β was lower in the group of infected. In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration.
publishDate 2019
dc.date.issued.none.fl_str_mv 2019
dc.date.accessioned.none.fl_str_mv 2022-11-21T14:49:51Z
dc.date.available.none.fl_str_mv 2022-11-21T14:49:51Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.identifier.citation.spa.fl_str_mv Álvarez-Larrotta C, Agudelo OM, Duque Y, Gavina K, Yanow SK, Maestre A, Carmona-Fonseca J, Arango E. Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid. Clin Exp Immunol. 2019 Jan;195(1):96-108. doi: 10.1111/cei.13213.
dc.identifier.issn.none.fl_str_mv 0009-9104
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/32164
dc.identifier.doi.none.fl_str_mv 10.1111/cei.13213
dc.identifier.eissn.none.fl_str_mv 1365-2249
identifier_str_mv Álvarez-Larrotta C, Agudelo OM, Duque Y, Gavina K, Yanow SK, Maestre A, Carmona-Fonseca J, Arango E. Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid. Clin Exp Immunol. 2019 Jan;195(1):96-108. doi: 10.1111/cei.13213.
0009-9104
10.1111/cei.13213
1365-2249
url https://hdl.handle.net/10495/32164
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Clin Exp Immunol
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.format.extent.spa.fl_str_mv 13
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv British Society for Immunology
dc.publisher.group.spa.fl_str_mv Salud y Comunidad
dc.publisher.place.spa.fl_str_mv Oxford, Inglaterra
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/1/AlvarezCatalina_2019_PlasmodiumPregnancyReducedAntibody.pdf
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spelling Álvarez Larrotta, CatalinaAgudelo García, Olga MaríaGavina, KennethYanow, Stephanie KimMaestre Buitrago, Amanda ElenaCarmona Fonseca, JaimeArango Flórez, Eliana María2022-11-21T14:49:51Z2022-11-21T14:49:51Z2019Álvarez-Larrotta C, Agudelo OM, Duque Y, Gavina K, Yanow SK, Maestre A, Carmona-Fonseca J, Arango E. Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid. Clin Exp Immunol. 2019 Jan;195(1):96-108. doi: 10.1111/cei.13213.0009-9104https://hdl.handle.net/10495/3216410.1111/cei.132131365-2249ABSTRACT: Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological conditions for parasite transmission fluctuate. In chronic infections, the persistence of the antigenic stimulus changes the expression of immune mediators and promotes constant immune regulation, including increases in regulatory T cell populations. These alterations of the immune system could compromise the response to routine vaccination. This study aimed to evaluate the effect of submicroscopic plasmodial infection with P. falciparum and P. vivax during pregnancy on the immune response to the tetanus toxoid vaccine in Colombian women. Expression of different cytokines and mediators of immune regulation and levels of anti-tetanus toxoid (TT) immunoglobulin (Ig)G were quantified in pregnant women with and without submicroscopic plasmodial infection. The anti-TT IgG levels were significantly lower in the infected group compared with the uninfected group. The expression of interferon (IFN)-γ, tumour necrosis factor (TNF) and forkhead box protein 3 (FoxP3) was significantly higher in the infected group, while the expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and transforming growth factor (TGF)-β was lower in the group of infected. In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration.COL004744913application/pdfengBritish Society for ImmunologySalud y ComunidadOxford, Inglaterrainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoidCitocinasCytokinesAnticuerpos AntibacterianosAntibodies, BacterialEnfermedad CrónicaChronic DiseaseLinfocitos T ReguladoresT-Lymphocytes, RegulatoryMalariaPlasmodium falciparumPlasmodium vivaxVacunasVaccinesComplicaciones Infecciosas del EmbarazoPregnancy Complications, InfectiousClin Exp ImmunolClinical and Experimental Immunology961081951ORIGINALAlvarezCatalina_2019_PlasmodiumPregnancyReducedAntibody.pdfAlvarezCatalina_2019_PlasmodiumPregnancyReducedAntibody.pdfArtículo de investigaciónapplication/pdf416070https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/1/AlvarezCatalina_2019_PlasmodiumPregnancyReducedAntibody.pdfc6b9212228a22dc940e9896f05303830MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/32164/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/32164oai:bibliotecadigital.udea.edu.co:10495/321642022-11-21 09:49:51.999Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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