Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection

ABSTRACT: For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antib...

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Autores:: Montaño Mendoza, Vicky Margarita
Méndez Cortina, Yorjagis Andrés
Rodríguez Perea, Ana Lucía
Fernández Geysson, Javier
Rugeles López, María Teresa
Velilla Hernández, Paula Andrea
Cardona Maya, Walter Darío

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2023

Institución:: Universidad de Antioquia

Repositorio:: Repositorio UdeA

Idioma:: eng

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Summary:	ABSTRACT: For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb) response and the cytokine production in coronavirus disease 2019 (COVID-19) subjects. The immune gene expression, according to biological sex and age, was assessed using the genome wide expression profile of blood proteins from healthy individuals using the Genotype Tissue Expression (GTEx) database. Moreover, anti-SARS-CoV-2 neutralizing antibody titers and cytokine levels were determined in blood samples from 141 COVID-19 individuals from Medellín, Colombia. Among subjects with COVID-19, males had statistically significantly higher median NAb titers and serum concentrations of interleukin-6 and CC chemokine ligand 3 than females. Overall, our findings point out a more robust innate immune response in women that could help recognize and restrain the virus faster than in men.

Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection

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