Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone

ABSTRACT: Background: Population and study’s methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. Objective: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. Methods...

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Autores:
Sánchez Caraballo, Jorge Mario
Cardona Villa, Ricardo
Álvarez Ricardo, Leidy Lucía
Tipo de recurso:
Article of investigation
Fecha de publicación:
2022
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/33179
Acceso en línea:
https://hdl.handle.net/10495/33179
Palabra clave:
Urticaria Crónica
Chronic Urticaria
Recurrencia
Recurrence
Prurito
Pruritus
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_27ae4f4b0277907570c74ba2e66253af
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/33179
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
title Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
spellingShingle Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
Urticaria Crónica
Chronic Urticaria
Recurrencia
Recurrence
Prurito
Pruritus
title_short Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
title_full Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
title_fullStr Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
title_full_unstemmed Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
title_sort Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
dc.creator.fl_str_mv Sánchez Caraballo, Jorge Mario
Cardona Villa, Ricardo
Álvarez Ricardo, Leidy Lucía
dc.contributor.author.none.fl_str_mv Sánchez Caraballo, Jorge Mario
Cardona Villa, Ricardo
Álvarez Ricardo, Leidy Lucía
dc.subject.decs.none.fl_str_mv Urticaria Crónica
Chronic Urticaria
Recurrencia
Recurrence
Prurito
Pruritus
topic Urticaria Crónica
Chronic Urticaria
Recurrencia
Recurrence
Prurito
Pruritus
description ABSTRACT: Background: Population and study’s methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. Objective: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. Methods: A total of 685 CSU patients (>12 years) were prospectively followed over 5 years. Diagnosis and follow-up of urticaria were based on medical evaluation and photographic records. Remission was defined as at least 6 months without symptoms (hives, angioedema, or pruritus) and medication. The follow-up included at least 2 visits per year, with photographic registration and clinical evaluation. Predefined clinical and paraclinical variables were included in the regression analyses. Results: We identified four clinical evolution pathways; The cumulative prevalence of remission at 5 years was 59.1%, recurrence was 17.1%, persistence was 11.6%, and chronic pruritus without hives or angioedema was 12.2%. The probability of persistence increased with hypothyroidism diagnosis (HR 0.425, 95% CI 0.290–0.621) and each point in the UAS7 (HR 0.931 95% CI 0.918– 0.945). Conclusion: Chronic urticaria has different evolutions. Disease activity and hypothyroidism predict persistence and remission. Recurrence and chronic pruritus phenotypes require further study to evaluate their causality and prognosis.
publishDate 2022
dc.date.issued.none.fl_str_mv 2022
dc.date.accessioned.none.fl_str_mv 2023-01-19T17:37:13Z
dc.date.available.none.fl_str_mv 2023-01-19T17:37:13Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.local.spa.fl_str_mv Artículo de investigación
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status_str publishedVersion
dc.identifier.citation.spa.fl_str_mv Sánchez J, Álvarez L, Cardona R. Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone. World Allergy Organ J. 2022 Oct 8;15(10):100705. doi: 10.1016/j.waojou.2022.100705.
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/33179
dc.identifier.doi.none.fl_str_mv 10.1016/j.waojou.2022.100705
dc.identifier.eissn.none.fl_str_mv 1939-4551
identifier_str_mv Sánchez J, Álvarez L, Cardona R. Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone. World Allergy Organ J. 2022 Oct 8;15(10):100705. doi: 10.1016/j.waojou.2022.100705.
10.1016/j.waojou.2022.100705
1939-4551
url https://hdl.handle.net/10495/33179
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv World. Allergy. Organ. J.
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.format.extent.spa.fl_str_mv 9
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.group.spa.fl_str_mv Grupo de Alergología Clínica y Experimental (GACE)
dc.publisher.place.spa.fl_str_mv Atlanta, Estados Unidos
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/33179/3/license_rdf
https://bibliotecadigital.udea.edu.co/bitstream/10495/33179/2/SanchezJorge_2022_ChronicUrticariae.pdf
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repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
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spelling Sánchez Caraballo, Jorge MarioCardona Villa, RicardoÁlvarez Ricardo, Leidy Lucía2023-01-19T17:37:13Z2023-01-19T17:37:13Z2022Sánchez J, Álvarez L, Cardona R. Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone. World Allergy Organ J. 2022 Oct 8;15(10):100705. doi: 10.1016/j.waojou.2022.100705.https://hdl.handle.net/10495/3317910.1016/j.waojou.2022.1007051939-4551ABSTRACT: Background: Population and study’s methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. Objective: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. Methods: A total of 685 CSU patients (>12 years) were prospectively followed over 5 years. Diagnosis and follow-up of urticaria were based on medical evaluation and photographic records. Remission was defined as at least 6 months without symptoms (hives, angioedema, or pruritus) and medication. The follow-up included at least 2 visits per year, with photographic registration and clinical evaluation. Predefined clinical and paraclinical variables were included in the regression analyses. Results: We identified four clinical evolution pathways; The cumulative prevalence of remission at 5 years was 59.1%, recurrence was 17.1%, persistence was 11.6%, and chronic pruritus without hives or angioedema was 12.2%. The probability of persistence increased with hypothyroidism diagnosis (HR 0.425, 95% CI 0.290–0.621) and each point in the UAS7 (HR 0.931 95% CI 0.918– 0.945). Conclusion: Chronic urticaria has different evolutions. Disease activity and hypothyroidism predict persistence and remission. Recurrence and chronic pruritus phenotypes require further study to evaluate their causality and prognosis.COL00595679application/pdfengElsevierGrupo de Alergología Clínica y Experimental (GACE)Atlanta, Estados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus aloneUrticaria CrónicaChronic UrticariaRecurrenciaRecurrencePruritoPruritusWorld. Allergy. Organ. J.World Allergy Organization Journal191510CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/33179/3/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD53ORIGINALSanchezJorge_2022_ChronicUrticariae.pdfSanchezJorge_2022_ChronicUrticariae.pdfArtículo de investigaciónapplication/pdf1090059https://bibliotecadigital.udea.edu.co/bitstream/10495/33179/2/SanchezJorge_2022_ChronicUrticariae.pdfec7e28e35aad8e01ea211586b72f5888MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/33179/4/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5410495/33179oai:bibliotecadigital.udea.edu.co:10495/331792023-01-19 12:39:25.433Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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