Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges
ABSTRACT: Methanolic extracts from eight Caribbean sponges (Demospongy Class, Filo Porifera) were evaluated against several selected parasites. The sponges studied were Ircinia strobilina, Ircinia felix, Ircinia campana, Xestospongia proxima, Xestospongia muta, Agelas conifera, Agelas clathrodes and...
- Autores:
-
Martínez Martínez, Alejandro
Robledo Restrepo, Sara María
Muñoz Herrera, Diana Lorena
Blair Trujillo, Silvia
Higuita Duarte, Elkin Albeiro
Echeverri Pineda, Edward Mauricio
Bedoya Arredondo, Jhon Jairo
Zea, Sven
Vélez Bernal, Iván Darío
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2001
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/22315
- Acceso en línea:
- http://hdl.handle.net/10495/22315
https://revistas.udea.edu.co/index.php/vitae/article/view/395
- Palabra clave:
- Antiparasitarios
Antiparasitic Agents
Esponjas
Sponges
Antiparasitic substances
Ircinia
Epidioxysterols
http://aims.fao.org/aos/agrovoc/c_7321
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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|
| dc.title.spa.fl_str_mv |
Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges |
| title |
Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges |
| spellingShingle |
Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges Antiparasitarios Antiparasitic Agents Esponjas Sponges Antiparasitic substances Ircinia Epidioxysterols http://aims.fao.org/aos/agrovoc/c_7321 |
| title_short |
Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges |
| title_full |
Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges |
| title_fullStr |
Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges |
| title_full_unstemmed |
Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges |
| title_sort |
Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges |
| dc.creator.fl_str_mv |
Martínez Martínez, Alejandro Robledo Restrepo, Sara María Muñoz Herrera, Diana Lorena Blair Trujillo, Silvia Higuita Duarte, Elkin Albeiro Echeverri Pineda, Edward Mauricio Bedoya Arredondo, Jhon Jairo Zea, Sven Vélez Bernal, Iván Darío |
| dc.contributor.author.none.fl_str_mv |
Martínez Martínez, Alejandro Robledo Restrepo, Sara María Muñoz Herrera, Diana Lorena Blair Trujillo, Silvia Higuita Duarte, Elkin Albeiro Echeverri Pineda, Edward Mauricio Bedoya Arredondo, Jhon Jairo Zea, Sven Vélez Bernal, Iván Darío |
| dc.subject.decs.none.fl_str_mv |
Antiparasitarios Antiparasitic Agents |
| topic |
Antiparasitarios Antiparasitic Agents Esponjas Sponges Antiparasitic substances Ircinia Epidioxysterols http://aims.fao.org/aos/agrovoc/c_7321 |
| dc.subject.agrovoc.none.fl_str_mv |
Esponjas Sponges |
| dc.subject.proposal.spa.fl_str_mv |
Antiparasitic substances Ircinia Epidioxysterols |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_7321 |
| description |
ABSTRACT: Methanolic extracts from eight Caribbean sponges (Demospongy Class, Filo Porifera) were evaluated against several selected parasites. The sponges studied were Ircinia strobilina, Ircinia felix, Ircinia campana, Xestospongia proxima, Xestospongia muta, Agelas conifera, Agelas clathrodes and Niphates erecta. The parasites used as bioindicators were Trypanosoma brucei, Trypanosoma cruzi, Leishmania infantum, Leishmania panamensis Plasmodium falciparum Itg2 and Plasmodium falciparum Ghana. The most active extracts were those obtained from the Ircinia felix, Ircinia campana and Xestospongia proxima sponges. The chromatographic fractionations of the methanolic extracts of the Ircinia felix and Ircinia campana sponges, allowed to isolate several fractions, of which those that showed the highest activity against amastigotes of Leishmania panamensis, contain complex mixtures of 5 & 8 & -epidioxysteols, according to the NMR analysis. -1H and HPLC. On the other hand, the most active fraction against Plasmodium falciparum Itg2 was a fraction obtained from the I. felix extract, which did not show evidence of the presence of 5 & 8 & -epidioxysteols or seterterpenic tetronic acids. |
| publishDate |
2001 |
| dc.date.issued.none.fl_str_mv |
2001 |
| dc.date.accessioned.none.fl_str_mv |
2021-09-08T03:15:58Z |
| dc.date.available.none.fl_str_mv |
2021-09-08T03:15:58Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.local.spa.fl_str_mv |
Artículo de investigación |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| status_str |
publishedVersion |
| dc.identifier.issn.none.fl_str_mv |
0121-4004 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/22315 |
| dc.identifier.eissn.none.fl_str_mv |
2145-2660 |
| dc.identifier.url.spa.fl_str_mv |
https://revistas.udea.edu.co/index.php/vitae/article/view/395 |
| identifier_str_mv |
0121-4004 2145-2660 |
| url |
http://hdl.handle.net/10495/22315 https://revistas.udea.edu.co/index.php/vitae/article/view/395 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Vitae |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
| dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-sa/4.0/ |
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11 |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Universidad de Antioquia, Facultad de Ciencias Farmacéuticas y Alimentarias |
| dc.publisher.group.spa.fl_str_mv |
Grupo Malaria Productos Naturales Marinos Programa de Estudio y Control de Enfermedades Tropicales (PECET) |
| dc.publisher.place.spa.fl_str_mv |
Medellín, Colombia |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/22315/1/MartinezAlejandro_2001_AntiparasiticActivityMethanolCaribbeanSponges.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/22315/2/license_rdf http://bibliotecadigital.udea.edu.co/bitstream/10495/22315/3/license.txt |
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andres.perez@udea.edu.co |
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Martínez Martínez, AlejandroRobledo Restrepo, Sara MaríaMuñoz Herrera, Diana LorenaBlair Trujillo, SilviaHiguita Duarte, Elkin AlbeiroEcheverri Pineda, Edward MauricioBedoya Arredondo, Jhon JairoZea, SvenVélez Bernal, Iván Darío2021-09-08T03:15:58Z2021-09-08T03:15:58Z20010121-4004http://hdl.handle.net/10495/223152145-2660https://revistas.udea.edu.co/index.php/vitae/article/view/395ABSTRACT: Methanolic extracts from eight Caribbean sponges (Demospongy Class, Filo Porifera) were evaluated against several selected parasites. The sponges studied were Ircinia strobilina, Ircinia felix, Ircinia campana, Xestospongia proxima, Xestospongia muta, Agelas conifera, Agelas clathrodes and Niphates erecta. The parasites used as bioindicators were Trypanosoma brucei, Trypanosoma cruzi, Leishmania infantum, Leishmania panamensis Plasmodium falciparum Itg2 and Plasmodium falciparum Ghana. The most active extracts were those obtained from the Ircinia felix, Ircinia campana and Xestospongia proxima sponges. The chromatographic fractionations of the methanolic extracts of the Ircinia felix and Ircinia campana sponges, allowed to isolate several fractions, of which those that showed the highest activity against amastigotes of Leishmania panamensis, contain complex mixtures of 5 & 8 & -epidioxysteols, according to the NMR analysis. -1H and HPLC. On the other hand, the most active fraction against Plasmodium falciparum Itg2 was a fraction obtained from the I. felix extract, which did not show evidence of the presence of 5 & 8 & -epidioxysteols or seterterpenic tetronic acids.RESUMEN: Se evaluaron contra varios parásitos seleccionados los extractos metanólicos de ocho esponjas caribeñas (Clase Demospongía, Filo Porifera). Las esponjas estudiadas fueron Ircinia strobilina, Ircinia felix, Ircinia campana, Xestospongia proxima, Xestospongia muta, Agelas conifera, Agelas clathrodes y Niphates erecta. Los parásitos utilizados como bioindicadores fueron Trypanosoma brucei, Trypanosoma cruzi, Leishmania infantum, Leishmania panamensis Plasmodium falciparum Itg2 y Plasmodium falciparum Ghana. Los extractos más activos fueron los obtenidos de las esponjas Ircinia felix, Ircinia campana y Xestospongia proxima. Los fraccionamientos cromatográficos de los extractos metanólicos de las esponjas Ircinia felix e Ircinia campana, permitieron aislar varias fracciones, de las cuales las que mostraron mayor actividad contra amastigotes de Leishmania panamensis, contienen mezclas complejas de 5&8&-epidioxiesteroles, de acuerdo con los análisis por RMN-1H y HPLC. Por otro lado, la fracción más activa contra Plasmodium falciparum Itg2 fue una fracción obtenida del extracto del I. felix, la cual no mostró evidencia de la presencia de 5&8&-epidioxiesteroles ni de ácidos tetrónicos seterterpénicos.COL0015043COL0015099COL000752411application/pdfengUniversidad de Antioquia, Facultad de Ciencias Farmacéuticas y AlimentariasGrupo MalariaProductos Naturales MarinosPrograma de Estudio y Control de Enfermedades Tropicales (PECET)Medellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Antiparasitic activity of methanol extracts and isolated fractions from caribbean spongesAntiparasitariosAntiparasitic AgentsEsponjasSpongesAntiparasitic substancesIrciniaEpidioxysterolshttp://aims.fao.org/aos/agrovoc/c_7321VitaeVitae718181ORIGINALMartinezAlejandro_2001_AntiparasiticActivityMethanolCaribbeanSponges.pdfMartinezAlejandro_2001_AntiparasiticActivityMethanolCaribbeanSponges.pdfArtículo de investigaciónapplication/pdf132654http://bibliotecadigital.udea.edu.co/bitstream/10495/22315/1/MartinezAlejandro_2001_AntiparasiticActivityMethanolCaribbeanSponges.pdfa2b8842b28b264f983dac1e44685ffadMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051http://bibliotecadigital.udea.edu.co/bitstream/10495/22315/2/license_rdfe2060682c9c70d4d30c83c51448f4eedMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/22315/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/22315oai:bibliotecadigital.udea.edu.co:10495/223152021-09-07 22:15:59.498Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |