Innate immune response to the dimorphic fungal pathogen Coccidioides : molecular and cellular mechanisms

ABSTRACT : Coccidioides spp is considered to be one of the most important fungal pathogen of humans. It is the causal agent of coccidioidomycosis, a systemic and endemic mycosis with a significant impact on public health, mainly in the United States, Central and South America. The host innate immune...

Full description

Autores:
González Marín, Ángel Augusto
Tipo de recurso:
Review article
Fecha de publicación:
2013
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/25038
Acceso en línea:
http://hdl.handle.net/10495/25038
Palabra clave:
Coccidioides
Coccidioidomicosis
Coccidioidomycosis
Inmunorrespuesta
Immune response
Toll-like receptor (TLR)
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-sa/2.5/co/
Description
Summary:ABSTRACT : Coccidioides spp is considered to be one of the most important fungal pathogen of humans. It is the causal agent of coccidioidomycosis, a systemic and endemic mycosis with a significant impact on public health, mainly in the United States, Central and South America. The host innate immune system appears to play an important role in the initial interaction and recognition of Coccidioides infection and the subsequent development of adaptive immunity. In this review article, I focus on the interaction between the innate immune response and Coccidioides in an attempt to increase our knowledge of the pathogenesis of this fungus.