Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture

ABSTRACT : Fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer using vinasses–molasses mixture is carried out in this work by implementing different process systems engineering tools. Two fed-batch strategies are tested experimentally at 5 L scale, considering only offline...

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Autores:
García Echeverry, Cesar Augusto
Alcaraz Zapata, Wilman
Acosta Cárdenas, Alejandro
Ochoa Cáceres, Silvia Mercedes
Tipo de recurso:
Article of investigation
Fecha de publicación:
2019
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/31118
Acceso en línea:
https://hdl.handle.net/10495/31118
Palabra clave:
Técnicas de Cultivo Celular por Lotes
Batch Cell Culture Techniques
Polihidroxialcanoatos
Polyhydroxyalkanoates
Melaza
Molasses
Modelos Biológicos
Models, Biological
Vinazas
Vinasse
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
id UDEA2_19cbd0fa6123e2abb4817f5124c7065c
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/31118
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture
title Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture
spellingShingle Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture
Técnicas de Cultivo Celular por Lotes
Batch Cell Culture Techniques
Polihidroxialcanoatos
Polyhydroxyalkanoates
Melaza
Molasses
Modelos Biológicos
Models, Biological
Vinazas
Vinasse
title_short Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture
title_full Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture
title_fullStr Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture
title_full_unstemmed Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture
title_sort Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses Mixture
dc.creator.fl_str_mv García Echeverry, Cesar Augusto
Alcaraz Zapata, Wilman
Acosta Cárdenas, Alejandro
Ochoa Cáceres, Silvia Mercedes
dc.contributor.author.none.fl_str_mv García Echeverry, Cesar Augusto
Alcaraz Zapata, Wilman
Acosta Cárdenas, Alejandro
Ochoa Cáceres, Silvia Mercedes
dc.subject.decs.none.fl_str_mv Técnicas de Cultivo Celular por Lotes
Batch Cell Culture Techniques
Polihidroxialcanoatos
Polyhydroxyalkanoates
Melaza
Molasses
Modelos Biológicos
Models, Biological
topic Técnicas de Cultivo Celular por Lotes
Batch Cell Culture Techniques
Polihidroxialcanoatos
Polyhydroxyalkanoates
Melaza
Molasses
Modelos Biológicos
Models, Biological
Vinazas
Vinasse
dc.subject.lemb.none.fl_str_mv Vinazas
Vinasse
description ABSTRACT : Fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer using vinasses–molasses mixture is carried out in this work by implementing different process systems engineering tools. Two fed-batch strategies are tested experimentally at 5 L scale, considering only offline information: (1) offline optimizing control and (2) exponential feeding. Application of these strategies showed that different feeding profiles result in different dynamic behaviour, influencing both, yield and biopolymer properties. As offline-based feeding strategies do not consider information of the culture status, they cannot deal with uncertainties. Therefore, a closed loop control strategy was implemented, which uses biomass and substrate information predicted online by soft-sensors. Results demonstrated the technical feasibility to produce biopolymer using a 75/25%vol. vinasses–molasses mixture. Successful implementation of the soft-sensor-based control strategy was evidenced at pilot plant scale, where sugar concentration was kept almost constant for 14 h, while obtaining the desired copolymer. Thus, proposed control strategy could be of interest at industrial-scale.
publishDate 2019
dc.date.issued.none.fl_str_mv 2019
dc.date.accessioned.none.fl_str_mv 2022-10-06T22:28:25Z
dc.date.available.none.fl_str_mv 2022-10-06T22:28:25Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
dc.type.local.spa.fl_str_mv Artículo de investigación
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 1615-7591
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/31118
dc.identifier.doi.none.fl_str_mv 10.1007/s00449-019-02102-z
dc.identifier.eissn.none.fl_str_mv 1615-7605
identifier_str_mv 1615-7591
10.1007/s00449-019-02102-z
1615-7605
url https://hdl.handle.net/10495/31118
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Bioprocess Biosyst. Eng.
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by/2.5/co/
dc.rights.accessrights.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/co/
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.extent.spa.fl_str_mv 15
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Springer
dc.publisher.group.spa.fl_str_mv Grupo de Biotransformación
Simulación Diseño Control y Optimización de Procesos (SIDCOP)
dc.publisher.place.spa.fl_str_mv Berlín, Alemania
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstream/10495/31118/1/GarciaCesar_2019_ApplicationProcessSystem.pdf
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repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
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spelling García Echeverry, Cesar AugustoAlcaraz Zapata, WilmanAcosta Cárdenas, AlejandroOchoa Cáceres, Silvia Mercedes2022-10-06T22:28:25Z2022-10-06T22:28:25Z20191615-7591https://hdl.handle.net/10495/3111810.1007/s00449-019-02102-z1615-7605ABSTRACT : Fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer using vinasses–molasses mixture is carried out in this work by implementing different process systems engineering tools. Two fed-batch strategies are tested experimentally at 5 L scale, considering only offline information: (1) offline optimizing control and (2) exponential feeding. Application of these strategies showed that different feeding profiles result in different dynamic behaviour, influencing both, yield and biopolymer properties. As offline-based feeding strategies do not consider information of the culture status, they cannot deal with uncertainties. Therefore, a closed loop control strategy was implemented, which uses biomass and substrate information predicted online by soft-sensors. Results demonstrated the technical feasibility to produce biopolymer using a 75/25%vol. vinasses–molasses mixture. Successful implementation of the soft-sensor-based control strategy was evidenced at pilot plant scale, where sugar concentration was kept almost constant for 14 h, while obtaining the desired copolymer. Thus, proposed control strategy could be of interest at industrial-scale.COL0066991COL005657415application/pdfengSpringerGrupo de BiotransformaciónSimulación Diseño Control y Optimización de Procesos (SIDCOP)Berlín, Alemaniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Application of process system engineering tools to the fed-batch production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from a vinasses–molasses MixtureTécnicas de Cultivo Celular por LotesBatch Cell Culture TechniquesPolihidroxialcanoatosPolyhydroxyalkanoatesMelazaMolassesModelos BiológicosModels, BiologicalVinazasVinasseBioprocess Biosyst. Eng.Bioprocess and Biosystems Engineering10231037426ORIGINALGarciaCesar_2019_ApplicationProcessSystem.pdfGarciaCesar_2019_ApplicationProcessSystem.pdfArtículo de investigaciónapplication/pdf2091258https://bibliotecadigital.udea.edu.co/bitstream/10495/31118/1/GarciaCesar_2019_ApplicationProcessSystem.pdfdb6b26aac556e7f6d3c7e1d4dd20ffd8MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927https://bibliotecadigital.udea.edu.co/bitstream/10495/31118/2/license_rdf1646d1f6b96dbbbc38035efc9239ac9cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/31118/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/31118oai:bibliotecadigital.udea.edu.co:10495/311182022-10-06 17:28:26.226Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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