Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols
ABSTRACT: Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In...
- Autores:
-
Márquez Fernández, Diana Margarita
Martínez Martínez, Alejandro
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2007
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/22307
- Acceso en línea:
- http://hdl.handle.net/10495/22307
https://revistas.udea.edu.co/index.php/vitae/article/view/587
- Palabra clave:
- Esponjas
Sponges
Ircinia
Epidioxysterols
epidioxiesteroles
http://aims.fao.org/aos/agrovoc/c_7321
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
| id |
UDEA2_18c1226c8e051800d0008fbbdd710708 |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/22307 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols |
| dc.title.alternative.spa.fl_str_mv |
Los epidioxiesteroles con actividad antileishmania de la esponja marina Colombiana Ircinia campana son productos de oxidación de los esteroles naturales 5,7 |
| title |
Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols |
| spellingShingle |
Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols Esponjas Sponges Ircinia Epidioxysterols epidioxiesteroles http://aims.fao.org/aos/agrovoc/c_7321 |
| title_short |
Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols |
| title_full |
Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols |
| title_fullStr |
Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols |
| title_full_unstemmed |
Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols |
| title_sort |
Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterols |
| dc.creator.fl_str_mv |
Márquez Fernández, Diana Margarita Martínez Martínez, Alejandro |
| dc.contributor.author.none.fl_str_mv |
Márquez Fernández, Diana Margarita Martínez Martínez, Alejandro |
| dc.subject.agrovoc.none.fl_str_mv |
Esponjas Sponges |
| topic |
Esponjas Sponges Ircinia Epidioxysterols epidioxiesteroles http://aims.fao.org/aos/agrovoc/c_7321 |
| dc.subject.proposal.spa.fl_str_mv |
Ircinia Epidioxysterols epidioxiesteroles |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_7321 |
| description |
ABSTRACT: Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In our search for antiparasitic metabolites from marine sponges, we found that the Colombian Caribbean sponge Ircinia campana contains a complex mixture of epidioxysterols which displayed antileishmanial activity. This paper demonstrates that epidioxysterols found in this sponge are photo-oxidation products from the naturally occurring ∆5,7 sterols. These results suggest that epidioxysterols reported previously in sponges of the genus Ircinia are not naturally occurring products, so they are not valid chemotaxonomic markers for the sponges of this genus. |
| publishDate |
2007 |
| dc.date.issued.none.fl_str_mv |
2007 |
| dc.date.accessioned.none.fl_str_mv |
2021-09-08T01:43:15Z |
| dc.date.available.none.fl_str_mv |
2021-09-08T01:43:15Z |
| dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.local.spa.fl_str_mv |
Artículo de investigación |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| status_str |
publishedVersion |
| dc.identifier.issn.none.fl_str_mv |
0121-4004 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/22307 |
| dc.identifier.eissn.none.fl_str_mv |
2145-2660 |
| dc.identifier.url.spa.fl_str_mv |
https://revistas.udea.edu.co/index.php/vitae/article/view/587 |
| identifier_str_mv |
0121-4004 2145-2660 |
| url |
http://hdl.handle.net/10495/22307 https://revistas.udea.edu.co/index.php/vitae/article/view/587 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Vitae |
| dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
| dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.format.extent.spa.fl_str_mv |
6 |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Universidad de Antioquia, Facultad de Ciencias Farmacéuticas y Alimentarias |
| dc.publisher.group.spa.fl_str_mv |
Productos Naturales Marinos |
| dc.publisher.place.spa.fl_str_mv |
Medellín, Colombia |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/22307/1/MarquezDiana_2007_AntileishmanialEpidioxysterolsColombianMarineSponge.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/22307/2/license_rdf http://bibliotecadigital.udea.edu.co/bitstream/10495/22307/3/license.txt |
| bitstream.checksum.fl_str_mv |
7f578ed71a87fb167fc7932b8aa0009b e2060682c9c70d4d30c83c51448f4eed 8a4605be74aa9ea9d79846c1fba20a33 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
| repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
| _version_ |
1812173178470924288 |
| spelling |
Márquez Fernández, Diana MargaritaMartínez Martínez, Alejandro2021-09-08T01:43:15Z2021-09-08T01:43:15Z20070121-4004http://hdl.handle.net/10495/223072145-2660https://revistas.udea.edu.co/index.php/vitae/article/view/587ABSTRACT: Marine sponges of the genus Ircinia are known to contain several classes of metabolites, some of them with interesting biological activities as furanesesterterpenes, polyprenylated hydroquinones, macrolides, sulfur containing terpenoids, and steroids with various patterns of oxidation. In our search for antiparasitic metabolites from marine sponges, we found that the Colombian Caribbean sponge Ircinia campana contains a complex mixture of epidioxysterols which displayed antileishmanial activity. This paper demonstrates that epidioxysterols found in this sponge are photo-oxidation products from the naturally occurring ∆5,7 sterols. These results suggest that epidioxysterols reported previously in sponges of the genus Ircinia are not naturally occurring products, so they are not valid chemotaxonomic markers for the sponges of this genus.RESUMEN: Las esponjas marinas del género Ircinia contienen varias clases de metabolitos, algunos de ellos con actividades biológicas interesantes como son: furanosesterterpenos, hidroquinonas polipreniladas, macrólidos, terpenoides azufrados, y esteroides con diferentes patrones de oxidación. En nuestra búsqueda de sustancias antiparasitarias en esponjas marinas, encontramos que la esponja marina colombiana Ircinia campana contiene una mezcla compleja de epidioxiesteroles, los cuales mostraron actividad antileishmania. Este trabajo demuestra que los epidioxiesteroles en esta esponja, son productos de la oxidación fotoquímica de sus esteroles naturales ∆5,7. Los resultados que se presentan sugieren que los epidioxiesteroles reportados previamente en otras esponjas del género Ircinia no son productos naturales y, por tanto, no son marcadores quimotaxonómicos válidos para este género de esponjas.COL00150436application/pdfengUniversidad de Antioquia, Facultad de Ciencias Farmacéuticas y AlimentariasProductos Naturales MarinosMedellín, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/Antileishmanial epidioxysterols from the Colombian marine sponge Ircinia campana are oxidation products from naturally occurring 5,7 sterolsLos epidioxiesteroles con actividad antileishmania de la esponja marina Colombiana Ircinia campana son productos de oxidación de los esteroles naturales 5,7EsponjasSpongesIrciniaEpidioxysterolsepidioxiesteroleshttp://aims.fao.org/aos/agrovoc/c_7321VitaeVitae6166141ORIGINALMarquezDiana_2007_AntileishmanialEpidioxysterolsColombianMarineSponge.pdfMarquezDiana_2007_AntileishmanialEpidioxysterolsColombianMarineSponge.pdfArtículo de investigaciónapplication/pdf96915http://bibliotecadigital.udea.edu.co/bitstream/10495/22307/1/MarquezDiana_2007_AntileishmanialEpidioxysterolsColombianMarineSponge.pdf7f578ed71a87fb167fc7932b8aa0009bMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051http://bibliotecadigital.udea.edu.co/bitstream/10495/22307/2/license_rdfe2060682c9c70d4d30c83c51448f4eedMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/22307/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/22307oai:bibliotecadigital.udea.edu.co:10495/223072021-09-07 20:43:15.621Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |